Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ros Eeles"'
Autor:
Holly Ni Raghallaigh, Ros Eeles
Publikováno v:
Journal of Clinical Oncology. 38:1505-1505
1505 Background: Genetic profiling could be used to target population screening for prostate cancer (PrCa). Approximately 170 single nucleotide polymorphisms (SNPs) have been identified that associate with PrCa development. Although these confer a lo
Autor:
Sarah Benafif, Ros Eeles, Ian Whitmore, Zsofia Kote-Jarai, Ezequiel Anokian, Clara Cieza-Borrella, Ed Saunders
Publikováno v:
Journal of Clinical Oncology. 36:e13617-e13617
e13617Background: The BARCODE2 study is investigating the response to platinum chemotherapy in men with advanced prostate cancer (PrCa) and a germline mutation in a DNA repair gene. We present the ...
Autor:
Zsofia Kote-Jarai, David V. Conti, Tokhir Dadaev, Ed Saunders, D. Leongamornlert, Ros Eeles, Sarah Wakerell, Clara Cieza Borrella, Mark N. Brook, Artitaya Lophatananon, Kenneth Muir, Ian Whitmore, K. Govindasami
Publikováno v:
Journal of Clinical Oncology. 36:18-18
18 Background: Prostate cancer (PrCa) is the most common solid tumour in men in the Western world. There is substantial evidence that PrCa predisposition is due both to common and rare germline variation. Methods: We screened 167 genes from DNA damag
Autor:
Ros Eeles, Sibel Saya, S.A. Sohaib, Leslie G. Walker, Elizabeth Bancroft, Dow-Mu Koh, Richard W Whitehouse, Emma Killick
Publikováno v:
Journal of Clinical Oncology. 35:1520-1520
1520 Background: In the United Kingdom, current screening guidelines for TP53 germline mutation carriers solely recommends annual breast MRI, despite the wide spectrum of malignancies typically seen in this group. Some centres employ family specific
Autor:
Johanna Schleutker, Kathleen Herkommer, Tiina Wahlfors, Zsofia Kote-Jarai, Josef Hoegel, Thomas J. Schnoeller, Christiane Maier, Antje E. Rinckleb, Liesel M. FitzGerald, Hans Krause, Manuel Luedeke, Steffen Weikert, Janet L. Stanford, Ros Eeles
Publikováno v:
Journal of Clinical Oncology. 33:5021-5021
5021 Background: HOXB13 was discovered as the first prostate cancer (PrCa) specific high-risk susceptibility gene. The most prevalent HOXB13 germline mutation in PrCa patients of European descent i...
Autor:
Tara M. Friebel, Joanne L. Blum, Timothy R. Rebbeck, Carol Aghajanian, Robert A. Soslow, Susan L. Neuhausen, Jason A. Konner, Ros Eeles, Douglas A. Levine, Patricia A. Ganz, Noah D. Kauff, Judy Garber, Malcolm C. Pike, Catherine A. Shu, Claudine Isaacs, Mary B. Daly, Mark E. Robson, Anjali R. Jotwani, Susan M. Domchek, Kenneth Offit
Publikováno v:
Journal of Clinical Oncology. 33:1504-1504
1504 Background: While RRSO is key in management for BRCA+ women, concomitant hysterectomy is not standard. Here we estimate the risk of Ut Ca in BRCA+ women following RRSO and examine the distribu...
Autor:
Elizabeth Page, Elena Castro, Ros Eeles, Natalie Taylor, Mahbubl Ahmed, Chee Leng Goh, Christos Mikropoulos, Elizabeth Bancroft
Publikováno v:
Journal of Clinical Oncology. 32:8-8
8 Background: Men with germline BRCA1/2 mutations have a higher risk of developing prostate cancer (PrCa) than non-carriers. IMPACT is an international consortium of 62 centers in 20 countries evaluating the use of targeted PrCa screening in men with
Autor:
Elizabeth Bancroft, Tokhir Dadaev, Natalie Taylor, Antonis C. Antoniou, Elizabeth Page, Christos Mikropoulos, Ros Eeles, Nandita M. deSouza, Diana Keating, Nigel Borley, Edward J. Saunders, Andy C. H. Lee, Elena Castro, Zsofia Kote-Jarai, Doug Easton, Mahbubl Ahmed
Publikováno v:
Journal of Clinical Oncology. 32:22-22
22 Background: Prostate cancer (PC) screening is controversial and a better assessment of individualized PC risk is needed. Several single nucleotide polymorphisms (SNPs) conferring a cumulative risk of PC have been identified. We have explored the p
Autor:
D. Leongamornlert, Chee Leng Goh, K. Govindasami, E J Sawyer, Douglas F. Easton, Chris Parker, Elizabeth Selvadurai, R A Wilkinson, Zsofia Kote-Jarai, Elena Castro, Malgorzata Tymrakiewicz, Ruth Woode-Amissah, Michelle Guy, Karen Thomas, Ali Amin Al Olama, E. Saunders, Ros Eeles, David Olmos, N. Mahmud, Tokhir Dadaev
Publikováno v:
Journal of Clinical Oncology. 31:e16000-e16000
e16000 Background: Prostate cancer (PCa) has a heritable risk and genome-wide association studies (GWAS) have so far identified 76 single nucleotide polymorphisms (SNPs) associated with PCa risk. Currently these SNPs have only been evaluated against
Autor:
David E. Neal, Diana Keating, Elizabeth Bancroft, Nandita M. deSouza, Elizabeth Page, Natalie Taylor, Antonis C. Antoniou, Tokhir Dadaev, Andy C. H. Lee, E. Saunders, Nigel Borley, Ros Eeles, Elena Castro, Zsofia Kote-Jarai
Publikováno v:
Journal of Clinical Oncology. 31:5054-5054
5054 Background: Prostate cancer (PC) screening is controversial and better approaches are needed, including a better assessment of individualized PC risk. Several studies have identified a number of common single nucleotide polymorphisms (SNPs) that