Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Gregory B Lesinski"'
Autor:
Gregory B. Lesinski, Ibrahim Halil Sahin, Sujata R. Kane, Clifford J. Gunthel, Jessica Guadagno, Edith Brutcher, Christina Wu, Bassel F. El-Rayes, Katherine Emilie Rhoades Smith
Publikováno v:
JCO Oncology Practice. 16:319-325
Recent studies have identified durable responses with the use of immune checkpoint inhibitors in patients with mismatch repair–deficient (MMR-D)/microsatellite instability–high (MSI-H) metastatic colorectal cancer (CRC). The dramatic improvement
Autor:
Walid L. Shaib, Gregory B. Lesinski, Olatunji B. Alese, Maria Diab, Manali Rupji, Mehmet Akce, Jeffrey M. Switchenko, Bassel F. El-Rayes, Christina Wu
Publikováno v:
Journal of Clinical Oncology. 39:95-95
95 Background: Preclinical data suggests metformin can improve immune exhaustion of tumor infiltrating lymphocytes and potentiate the effects of PD-1 blockade. By normalizing the hypoxic TME, metformin was shown to improve cytotoxic T cell function a
Autor:
Gregory B. Lesinski, Anthony P. Martinez, Terrence L. Fisher, Elizabeth E. Evans, Michael C. Lowe, Melanie Allor, Brian Olson, Melinda L. Yushak, Crystal Mallow, Christine Reilly, Keith A. Delman, Ragini R. Kudchadkar, Jacklyn Hammons
Publikováno v:
Journal of Clinical Oncology. 38:10061-10061
10061 Background: SEMA4D has broad immunomodulatory effects in the tumor microenvironment (TME); blocking SEMA4D in combination with checkpoint inhibitors (CI) promotes immune infiltration, reduces recruitment of myeloid cells, enhances T cell activi
Autor:
Michael C. Lowe, Gregory B. Lesinski, Ragini R. Kudchadkar, Keith A. Delman, Terrence L. Fisher, Melinda L. Yushak, Elizabeth E. Evans
Publikováno v:
Journal of Clinical Oncology. 37:TPS9603-TPS9603
TPS9603 Background: Interrogation of the tumor microenvironment (TME) is crucial to provide insight into biological activity, resistance mechanisms and implementation of rational combination immunotherapies. Semaphorin 4D (SEMA4D, CD100) has broad im