Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Gregory B Lesinski"'
Autor:
Gregory B. Lesinski, Ibrahim Halil Sahin, Sujata R. Kane, Clifford J. Gunthel, Jessica Guadagno, Edith Brutcher, Christina Wu, Bassel F. El-Rayes, Katherine Emilie Rhoades Smith
Publikováno v:
JCO Oncology Practice. 16:319-325
Recent studies have identified durable responses with the use of immune checkpoint inhibitors in patients with mismatch repair–deficient (MMR-D)/microsatellite instability–high (MSI-H) metastatic colorectal cancer (CRC). The dramatic improvement
Autor:
Walid L. Shaib, Gregory B. Lesinski, Olatunji B. Alese, Maria Diab, Manali Rupji, Mehmet Akce, Jeffrey M. Switchenko, Bassel F. El-Rayes, Christina Wu
Publikováno v:
Journal of Clinical Oncology. 39:95-95
95 Background: Preclinical data suggests metformin can improve immune exhaustion of tumor infiltrating lymphocytes and potentiate the effects of PD-1 blockade. By normalizing the hypoxic TME, metformin was shown to improve cytotoxic T cell function a
Autor:
Edmund K. Waller, Lily Yang, Gregory B. Lesinski, Ramireddy Bommireddy, Brianna Flynn, Alexandra Waller, Christopher T. Petersen, Bassel F. El-Rayes, Mohammad Raheel Jajja, Sruthi Ravindranathan, Periasamy Selvaraj
Publikováno v:
Journal of Clinical Oncology. 37:e15183-e15183
e15183 Background: Current immunotherapies fail to benefit patients with colon cancer, largely due to high molecular heterogeneity and low frequencies of tumor infiltrating lymphocytes. In this study, we are addressing this limitation via a novel tec