Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Xinxin Ding"'
Autor:
Yurong Lai, Xinxin Ding
Publikováno v:
Drug Metabolism and Disposition. 51:645-646
Publikováno v:
Drug Metabolism and Disposition. 47:1469-1478
Previous studies using Cyp2abfgs-null (lacking all genes of the Cyp2a, 2b, 2f, 2g, and 2s subfamilies), CYP2A13/2F1-humanized, and liver-Cpr-null (LCN) mice showed that although hepatic cytochrome P450 (P450) enzymes are essential for systemic cleara
Autor:
Xinxin, Ding
Publikováno v:
Drug Metabolism and Disposition. 49:1-2
Publikováno v:
Drug Metabolism and Disposition. 43:1326-1330
Cytochrome P450 monooxygenases (P450s), which are well-known drug-metabolizing enzymes, are thought to play a signal transduction role in µ opioid analgesia and may serve as high-affinity (3)H-cimetidine ((3)HCIM) binding sites in the brain. (3)HCIM
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 354:10-17
The potential involvement of intestinal microsomal cytochrome P450 (P450) enzymes in defending against colon inflammation and injury was studied in mice treated with dextran sulfate sodium (DSS) to induce colitis. Wild-type (WT) mice and mice with in
Publikováno v:
Drug Metabolism and Disposition. 42:1341-1348
CYP2A13, CYP2B6, and CYP2F1 are neighboring cytochrome P450 genes on human chromosome 19, and the enzymes that they encode overlap in substrate specificity. A CYP2A13/2B6/2F1-transgenic mouse, in which CYP2A13 and 2F1 are both expressed in the respir
Publikováno v:
Molecular Pharmacology. 85:139-147
Tissue-specific deletion of the gene for NADPH-cytochrome P450 (P450) reductase (CPR), the essential electron donor to all microsomal P450 enzymes, in either liver or intestine, leads to upregulation of many P450 genes in the tissue with the Cpr dele
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 347:746-754
Nicotine metabolism is believed to affect not only nicotine’s pharmacological effects but also nicotine addiction. As a key step toward testing this hypothesis, we have studied nicotine metabolism and nicotine’s pharmacological and behavioral eff
Publikováno v:
Drug Metabolism and Disposition. 41:1782-1786
The aryl hydrocarbon receptor (AHR)-dependent induction of cytochromes P450 (P450) such as CYP1A1 by 3-methylcholanthrene (MC) and related polycyclic aromatic hydrocarbons is well characterized. We reported previously that MC treatment triggers a pro
Publikováno v:
Drug Metabolism and Disposition. 41:529-535
The study was originally designed to test the hypothesis that the compensatory increase in intestinal P450 (cytochrome P450) expression in the intestinal epithelium-specific P450 reductase (CPR) knockout (IE-Cpr-null) mice was attributable to decreas