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pro vyhledávání: '"William M. Lee"'
Autor:
Laura P. James, Dean W. Roberts, Jack A. Hinson, William M. Lee, Lynda Letzig, Timothy J. Davern, Edmund V. Capparelli, Pippa Simpson
Publikováno v:
Drug Metabolism and Disposition. 37:1779-1784
Acetaminophen (APAP)-induced liver toxicity occurs with formation of APAP-protein adducts. These adducts are formed by hepatic metabolism of APAP to N-acetyl-p-benzoquinone imine, which covalently binds to hepatic proteins as 3-(cystein-S-yl)-APAP ad
Autor:
Andrew Mulato, Nilima Kutty, Gabriel Birkus, Gong-Xin He, Tomas Cihlar, Martin J. Mcdermott, William M. Lee
Publikováno v:
Molecular Pharmacology. 74:92-100
9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl]adenine (GS-7340) is an isopropylalaninyl phenyl ester prodrug of the nucleotide HIV reverse transcriptase inhibitor tenofovir (TFV; 9-[(2-phosphonomethoxy)prop