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Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 368:237-245
Glial activation plays a pivotal role in morphine tolerance. This study investigated effects of Mas-related gene (Mrg) C receptor on morphine-induced activation of microglia and astrocytes in the spinal cord and its underlying mechanisms. Intrathecal
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 356:2-12
Methylmercury (MeHg) disrupts cerebellar function, especially during development. Cerebellar granule cells (CGC), which are particularly susceptible to MeHg by unknown mechanisms, migrate during this process. Transient changes in intracellular Ca(2+)
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 349:470-479
Lubiprostone, a bicyclic fatty acid derived from prostaglandin E1, has been used to treat chronic constipation and irritable bowel syndrome, and its mechanism of action has been attributed to the stimulation of intestinal fluid secretion via the acti
Autor:
Zheng-Ming Ding, William J. McBride, Richard L. Bell, Zachary A. Rodd, Scott M. Oster, Jamie E. Toalston, Sheketha R. Hauser
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 340:202-209
Ethanol (EtOH) and cocaine are both self-administered into the posterior ventral tegmental area (VTA). Self-administration of either drug is prevented by coadministration of a serotonin (5-HT3) receptor antagonist. Electrophysiological studies indica
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 334:753-760
Chronic hypoxia (CH)-induced pulmonary hypertension is associated with decreased basal pulmonary artery endothelial cell (EC) Ca2+, which correlates with reduced store-operated Ca2+ (SOC) entry. Protein kinase C (PKC) attenuates SOC entry in ECs. The
Autor:
Li-Xin Jiang, Steven M. Grauer, Feng Liu, Sheree F. Logue, Nicholas J. Brandon, Barbara Langen, Michael S. Malamas, Ute Egerland, Rachel Navarra, Cody Kelley, Erik I. Charych, Thomas A. Comery, Michy P. Kelly, Karen L. Marquis, Radka Graf, Thorsten Hage, Julie A. Brennan, Virginia L. Pulito
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 331:574-590
Following several recent reports that suggest that dual cAMP and cGMP phosphodiesterase 10A (PDE10A) inhibitors may present a novel mechanism to treat positive symptoms of schizophrenia, we sought to extend the preclinical characterization of two suc
Publikováno v:
Molecular Pharmacology. 76:618-631
Recent preclinical and clinical research has shown that almorexant promotes sleep in animals and humans without disrupting the sleep architecture. Here, the pharmacology and kinetics of [(3)H]almorexant binding to human orexin 1 receptor (OX(1))- and
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 328:963-969
The immunomodulator fingolimod (FTY720) induces lymphopenia by inhibiting lymphocyte egress from thymus and secondary lymphoid organs (SLOs). It is phosphorylated mainly by sphingosine kinase (SK) 2 in vivo. FTY720-phosphate (FTY-P) activated and rap
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 326:725-731
Pharmacological and behavioral studies suggest that spinal delta- and kappa-opioid antinociceptive systems are functionally associated with ovarian sex steroids. These interactions can be demonstrated specifically during pregnancy or hormone-simulate
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 325:691-697
Food restriction enhances sensitivity to the reinforcing effects of a variety of drugs of abuse including opiates, nicotine, and psychostimulants. Food restriction has also been shown to alter a variety of behavioral and pharmacological responses to