Zobrazeno 1 - 10
of 25
pro vyhledávání: ''
Autor:
Shin Irie, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama, Ichiro Ieiri, Miyuki Kimura, Takashi Yoshikado, Soo-Jin Kim
Publikováno v:
Drug Metabolism and Disposition. 44:1622-1632
Clopidogrel is reported to be associated with cerivastatin-induced rhabdomyolysis, and clopidogrel and its metabolites are capable of inhibiting CYP2C8 and OATP 1B1 in vitro. The objective of the present study was to identify the mechanism of clopido
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 346:350-361
Marijuana substitutes often contain blends of multiple psychoactive synthetic cannabinoids (SCBs), including the prevalent SCBs (1-pentyl-1H-indole-3-yl)-1-naphthalenyl-methanone (JWH-018) and (1-butyl-1H-indole-3-yl)-1-naphthalenyl-methanone (JWH-07
Autor:
Thierry Bouyssou, Ingo Konetzki, Emmanuel Naline, Sabine Pestel, Philippe Devillier, Andreas Schnapp, Paola Casarosa
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 334:53-62
The preclinical pharmacological profile of 6-hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one monohydrochloride (olodaterol, previously known as BI 1744 CL), a novel, enantiomeric pure, inha
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 332:738-746
Dauricine is the major bioactive component isolated from the roots of Menispermum dauricum D.C. and has shown promising pharmacological activities with a great potential for clinic use. However, the adverse effects and toxicity of the alkaloid are un
Autor:
Frederick A. Villamena, Jay L. Zweier, Li Zuo, Hsin Ling Lee, Levy Reyes, Chwen Lih Chen, Yeong Renn Chen
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 329:515-523
Free radicals are important mediators of myocardial ischemia-reperfusion injury. Nitrone spin traps have been shown to scavenge free radicals. The cardioprotective effect of the spin trap, 5,5-dimethyl-1-pyrroline N-oxide (DMPO), was investigated in
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 329:820-826
Rho kinase is involved in the pathogenesis of hypertension, which favors the occurrence of endothelium-dependent contractions. The present study was designed to determine the effects of two Rho kinase inhibitors, HA1077 [1-(5-isoquinolinesulfonyl)-ho
Autor:
Inkyeom Kim, Young Mi Seok, Yong-Hoon Kim, In-Jung Lee, Dong Hyun Shin, Inji Baek, Young Hyun Hwang, Yeon-Shin Jeong
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 326:991-998
Isoflavones decrease blood pressure, improve lipid profiles, and restore vascular function. We hypothesized that isoflavone attenuates vascular contraction by inhibiting RhoA/Rho-kinase signaling pathway. Rat aortic rings were denuded of endothelium,
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 323:391-397
Puerarin is the main isoflavone found in Pueraria lobata (Willd) Ohwi, which has been used in therapy for various cardiovascular diseases. The present study examined the effects of puerarin on the large-conductance voltage- and Ca2+-activated potassi
Autor:
Danielle Ianzer, Gisele M Etelvino, Carlos Henrique Xavier, Leonor Tapias Machado, Jerusa A. Santos, Vincent Dive, B.C. Prezoto, Robson A.S. Santos, Antonio C.M. Camargo, Elizabeth Pereira Mendes
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 322:795-805
Angiotensin-converting enzyme (ACE) inhibitors were developed based on proline-rich oligopeptides found in the venom of Bothrops jararaca ( Bj ) previously known as bradykinin-potentiating peptides (BPPs). However, the exact mechanism of action of BP
Autor:
Mei-Yee Wong, Melissa Santikul, Luiz Belardinelli, Arvinder Dhalla, Michelle D. Smith, John C. Shryock
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 321:327-333
Elevated lipolysis and circulating free fatty acid (FFA) levels have been linked to the pathogenesis of insulin resistance. A1 adenosine receptor agonists are potent inhibitors of lipolysis. Several A1 agonists have been tested as potential antilipol