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Autor:
Liang Xu, Wenhui Cui, Xiaoting Mo, Liu-Cheng Li, De-Lin Li, Jun Li, Wencheng Zhou, Ping Zhao, Jian Gao
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 354:302-309
Epithelial-to-mesenchymal transition (EMT) is a crucial event in the cellular origin of myofibroblasts that secrete extracellular matrix in the progression of pulmonary fibrosis (PF). High-mobility group box 1 (HMGB1) is a novel mediator of EMT. Howe
Autor:
Vasileios Kotsikoris, Bukar Umaru, Andreas Papapetropoulos, Stavros Topouzis, Anastasia Pyriochou
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 354:79-87
Intense research is conducted to identify new molecular mechanisms of angiogenesis. Previous studies have shown that the angiogenic effects of hydrogen sulfide (H2S) depend on the activation of ATP-sensitive potassium channels (KATP) and that C-type
Publikováno v:
Molecular Pharmacology. 87:277-285
Re-epithelialization begins early during skin wound healing and is regulated by various growth factors and cytokines. Angiotensin II promotes the migration of keratinocytes and thereby contributes to wound healing. We investigated the mechanism by wh
Autor:
Yong Zhou, Philip J. O'Reilly, Meng Hu, Rui-Ming Liu, Guo-Qiang Cai, Veena B. Antony, Xiaosi Han, Pulin Che, Gang Liu, Tracy Luckhardt, Victor J. Thannickal, Qiang Ding, Leena P. Desai, Gene P. Siegal
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 351:87-95
Myofibroblasts are effector cells in fibrotic disorders that synthesize and remodel the extracellular matrix (ECM). This study investigated the role of the Src kinase pathway in myofibroblast activation in vitro and fibrogenesis in vivo. The profibro
Publikováno v:
Molecular Pharmacology. 80:930-942
Two different mechanisms leading to increased current have been described for the small-molecule human ether-à-go-go-related gene (herg) activator NS1643 [1,3-bis-(2-hydroxy-5-trifluoromethylphenyl)-urea]. On herg1a channels expressed in Xenopus lae
Publikováno v:
Molecular Pharmacology. 79:974-986
Glycogen synthase kinase-3 (GSK3) is a constitutively active protein kinase that is involved in neuronal regulation and is a potential pharmacological target of neurological disorders. We found previously that GSK3β selectively interacts with 5-hydr
Autor:
Lianne B. Dale, Christina M. Godin, Sean P. Cregan, Lucimar T. Ferreira, Robert Gros, Stephen S. G. Ferguson
Publikováno v:
Molecular Pharmacology. 77:388-395
The angiotensin II type 1 receptor (AT(1)R) plays an important role in cardiovascular function and as such represents a primary target for therapeutic intervention. The AT(1)R has traditionally been considered to be coupled to the activation of phosp
Autor:
Jayesh Patel, Ortrud K. Steinlein, Richard Roberts, David Goudie, Samuel F. Berkovic, Ingrid E. Scheffer, Wenli Gu, Stylianos E. Antonarakis, Jean-Charles Hoda, H.A. Phillips, Marc Friedli, Carla Marini, Daniel Bertrand, John C. Mulley, Sonia Bertrand
Publikováno v:
Molecular pharmacology, Vol. 74, No 2 (2008) pp. 379-91
Certain mutations in specific parts of the neuronal nicotinic acetylcholine receptor (nAChR) subunit genes CHRNA4, CHRNB2, and probably CHRNA2, can cause autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). All but one of the known causative
Publikováno v:
Molecular Pharmacology. 73:1502-1512
A previous study from this laboratory showed that oltipraz and synthetic dithiolethiones prevent tumor necrosis factor-alpha-induced hepatic insulin resistance via AMP-activated protein kinase-dependent p70S6 kinase (S6K) 1 inhibitory pathway. This s
Publikováno v:
Molecular Pharmacology. 73:314-322
Converging evidence has suggested that anandamide (AEA), an endogenous agonist of cannabinoid (CB) receptors, can directly interact with certain types of ligand-gated ion channels (LGICs). However, little is known about the molecular and cellular mec