Zobrazeno 1 - 10
of 286
pro vyhledávání: '"Mcbride, A."'
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTSporulation is an important feature of the clostridial life cycle, facilitating survival of these bacteria in harsh environments, contributing to disease transmission for pathogenic species, and sharing common early steps that are also involv
Externí odkaz:
https://doaj.org/article/f6775f9742c9444da88ea5260b3adcd2
Autor:
Chad H. Hogan, Shana M. Owens, Glennys V. Reynoso, Yifei Liao, Thomas J. Meyer, Monika A. Zelazowska, Bin Liu, Xiaofan Li, Anna K. Grosskopf, Camille Khairallah, Varvara Kirillov, Nancy C. Reich, Brian S. Sheridan, Kevin M. McBride, Benjamin E. Gewurz, Heather D. Hickman, J. Craig Forrest, Laurie T. Krug
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Cancers associated with the oncogenic gammaherpesviruses, Epstein-Barr virus and Kaposi sarcoma herpesvirus, are notable for their constitutive activation of the transcription factor signal transducer and activator of transcription 3 (STAT3)
Externí odkaz:
https://doaj.org/article/6bccdfd5801d4610bd4ecd1dd2dfb2cc
Autor:
Kyle R. Smith, Somnath Paul, Qiwen Dong, Orchi Anannya, Darby G. Oldenburg, J. Craig Forrest, Kevin M. McBride, Laurie T. Krug
Publikováno v:
mSphere, Vol 8, Iss 5 (2023)
ABSTRACT Herpesviruses are large double-stranded DNA viruses that encode core replication proteins and accessory factors involved in nucleotide metabolism and DNA repair. Mammalian uracil-DNA glycosylases (UNG) excise deleterious uracil residues from
Externí odkaz:
https://doaj.org/article/db2ec48fefc6463ba061614bbbfb2d73
Autor:
Nicholas A. Lesniak, Sarah Tomkovich, Andrew Henry, Ana Taylor, Joanna Colovas, Lucas Bishop, Kathryn McBride, Patrick D. Schloss
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Fecal communities transplanted into individuals can eliminate recurrent Clostridioides difficile infection (CDI) with high efficacy. However, this treatment is only used once CDI becomes resistant to antibiotics or has recurred multiple time
Externí odkaz:
https://doaj.org/article/d4a208c06efb4caf9f8cee2be1e4516a
Autor:
LaNisha L. Patterson, Thangam Sudha Velayutham, Caitlan D. Byerly, Duc Cuong Bui, Jignesh Patel, Veljko Veljkovic, Slobodan Paessler, Jere W. McBride
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Ehrlichia chaffeensis evades innate host defenses by reprogramming the mononuclear phagocyte through mechanisms that involve the exploitation of multiple evolutionarily conserved cellular signaling pathways, including Notch. This immune evas
Externí odkaz:
https://doaj.org/article/294c6c6b6474458b87a6a1a25d98e976
Autor:
Anubama Rajan, Ashley Morgan Weaver, Gina Marie Aloisio, Joseph Jelinski, Hannah L. Johnson, Susan F. Venable, Trevor McBride, Letisha Aideyan, Felipe-Andrés Piedra, Xunyan Ye, Ernestina Melicoff-Portillo, Malli Rama Kanthi Yerramilli, Xi-Lei Zeng, Michael A. Mancini, Fabio Stossi, Anthony W. Maresso, Shalaka A. Kotkar, Mary K. Estes, Sarah Blutt, Vasanthi Avadhanula, Pedro A. Piedra
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT There is an unmet need for preclinical models to understand the pathogenesis of human respiratory viruses and predict responsiveness to immunotherapies. Airway organoids can serve as an ex vivo human airway model to study respiratory viral p
Externí odkaz:
https://doaj.org/article/d19e06d3907d4ae0a97b769078363018
Publikováno v:
mSphere, Vol 6, Iss 6 (2021)
ABSTRACT The formation of dormant spores is essential for the anaerobic pathogen Clostridioides difficile to survive outside the host gastrointestinal tract. The regulatory pathways and environmental signals that initiate C. difficile spore formation
Externí odkaz:
https://doaj.org/article/0f46bf8111414b378b38c6dc9d990081
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT The life cycle of human papillomavirus (HPV) depends on keratinocyte differentiation as the virus modulates and takes advantage of cellular pathways to replicate its genome and assemble viral particles in differentiated cells. Viral genomes
Externí odkaz:
https://doaj.org/article/f31a631ba8ce4648b8bacf7d8c4ae011
Autor:
Sarah Tomkovich, Ana Taylor, Jacob King, Joanna Colovas, Lucas Bishop, Kathryn McBride, Sonya Royzenblat, Nicholas A. Lesniak, Ingrid L. Bergin, Patrick D. Schloss
Publikováno v:
mSphere, Vol 6, Iss 5 (2021)
Diarrheal samples from patients taking laxatives are typically rejected for Clostridioides difficileC. difficile
Externí odkaz:
https://doaj.org/article/eb46b3f494ee4faab120bfb02bea0cc6
Autor:
Katarzyna Lorencik, Robert Ekiert, Yongtao Zhu, Mark J. McBride, Robert B. Gennis, Marcin Sarewicz, Artur Osyczka
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 1 (2021)
ABSTRACT Bacterial alternative complex III (ACIII) catalyzes menaquinol (MKH2) oxidation, presumably fulfilling the role of cytochromes bc1/b6f in organisms that lack these enzymes. The molecular mechanism of ACIII is unknown and so far the complex h
Externí odkaz:
https://doaj.org/article/58704c3ed1b94ff88ebf34ef3118ed50