Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Makarov, A. A."'
Autor:
Angela Koryakova, Victoria Shcherbakova, Olga Riabova, Yurii Kazaishvili, Roman Bolgarin, Vadim Makarov
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT Macozinone (MCZ; PBTZ169) is a first-in-class antituberculosis clinical-stage benzothiazinone-based drug candidate. Although its efficacy and safety have been strongly proven in several preclinical and clinical studies, the physicochemical a
Externí odkaz:
https://doaj.org/article/4d5aefe962904eb396a4277f69f058b4
Autor:
Elena G. Salina, Umberto Postiglione, Laurent R. Chiarelli, Deborah Recchia, Monika Záhorszká, Alexander Lepioshkin, Natalia Monakhova, Adrian Pál, Alessio Porta, Giuseppe Zanoni, Jana Korduláková, Elena Kazakova, Davide Sassera, Maria Rosalia Pasca, Vadim Makarov, Giulia Degiacomi
Publikováno v:
mSphere, Vol 7, Iss 6 (2022)
ABSTRACT Tuberculosis (TB) still poses a global menace as one of the deadliest infectious diseases. A quarter of the human population is indeed latently infected with Mycobacterium tuberculosis. People with latent infection have a 5 to 10% lifetime r
Externí odkaz:
https://doaj.org/article/df59359de4744e088c1593f4deded2ce
Autor:
Salina, Elena G., Postiglione, Umberto, Chiarelli, Laurent R., Recchia, Deborah, Záhorszká, Monika, Lepioshkin, Alexander, Monakhova, Natalia, Pál, Adrian, Porta, Alessio, Zanoni, Giuseppe, Korduláková, Jana, Kazakova, Elena, Sassera, Davide, Pasca, Maria Rosalia, Makarov, Vadim, Degiacomi, Giulia
Publikováno v:
MSphere; Dec2022, Vol. 7 Issue 6, p1-19, 19p
Autor:
Barbara Kropff, Thomas C. Mettenleiter, Janna Schmitz, Vadim Makarov, Marco Thomas, Elke Bogner, Rebekka Adfeldt, Natalia Monakhova, Barbara G. Klupp, Julia E. Hölper
Publikováno v:
Antimicrob Agents Chemother
Herpesviruses are widespread and can cause serious illness. Many currently available antiviral drugs have limited effects, result in rapid development of resistance, and often exhibit dose-dependent toxicity. Especially for human cytomegalovirus (HCM
Autor:
Xuan Li, Olga Riabova, Michael Domaratzki, Laurent R. Chiarelli, Silvia Buroni, Silvia T. Cardona, Marco Biggiogera, Giovanna Riccardi, Natalia Monakhova, Alberto Azzalin, April S. Gislason, Maria S. Stietz, Andrew M. Hogan, Viola Camilla Scoffone, Ann Karen C. Brassinga, Haben H Tesfu, Vadim Makarov
Publikováno v:
Antimicrobial Agents and Chemotherapy
To streamline the elucidation of antibacterial compounds’ mechanism of action, comprehensive high-throughput assays interrogating multiple putative targets are necessary. However, current chemogenomic approaches for antibiotic target identification
Autor:
Anthony Vocat, Jean-Yves Gillon, Stewart T. Cole, Andréanne Lupien, Caroline S. Foo, Vadim Makarov, Emilyne Blattes
Publikováno v:
Antimicrobial Agents and Chemotherapy. 62
The efficacy of the standardized four-drug regimen (comprising isoniazid, rifampin, pyrazinamide, and ethambutol) for the treatment of tuberculosis (TB) is menaced by the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) str
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:55-60
From in vivo observations, a majority of M. tuberculosis cells in latently infected individuals are in a dormant and probably nonculturable state, display little metabolic activity, and are phenotypically resistant to antibiotics. Despite many attemp
Human cytomegalovirus (HCMV) can cause life-threatening diseases in neonates and immunocompromised patients. Due to multiple problems caused by the current available drugs, development of new antiviral compounds is urgently needed. In this study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b3bd798cac5de2882ed7184844c9a6
https://europepmc.org/articles/PMC4023779/
https://europepmc.org/articles/PMC4023779/
Autor:
Ruben C. Hartkoorn, Anthony Vocat, Katarína Mikušová, Elena Kazakova, João Neres, Trent M. Conroy, O. B. Ryabova, Jérémie Piton, Michal Šarkan, Vadim Makarov, Stanislav Huszár, Gaëlle S. Kolly, Stewart T. Cole
8-Nitro-benzothiazinones (BTZs), such as BTZ043 and PBTZ169, inhibit decaprenylphosphoryl-β- d -ribose 2′-oxidase (DprE1) and display nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro . Structure-activity relationship (SA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30730f59186b1402cb4ef1f895a65322
https://infoscience.epfl.ch/record/213880
https://infoscience.epfl.ch/record/213880
Autor:
Selinka, Hans-Christoph1, Florin, Luise1, Patel, Hetal D.2, Freitag, Kirsten1, Schmidtke, Michaela3, Makarov, Vadim A.4, Sapp, Martin2 msapp1@lsuhsc.edu
Publikováno v:
Journal of Virology. Oct2007, Vol. 81 Issue 20, p31-31. 1p.