Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Álvaro Pascual"'
Autor:
Inés Bleriot, Lucia Blasco, Olga Pacios, Laura Fernández-García, María López, Concha Ortiz-Cartagena, Antonio Barrio-Pujante, Felipe Fernández-Cuenca, Álvaro Pascual, Luis Martínez-Martínez, Jesús Oteo-Iglesias, María Tomás
Publikováno v:
Microbiology Spectrum. 11
Researchers, including microbiologists and infectious disease specialists, require more knowledge about the interactions between phages and their bacterial hosts and about their defense mechanisms. In this study, we analyzed the molecular mechanisms
Autor:
Marina R. Pulido, Andrea García-Montaner, Lorena López-Cerero, Felipe Fernández-Cuenca, José Gutiérrez-Fernández, Álvaro Pascual
This study characterizes a new genetic structure containing a multicopy of a blaVIM-2 variant with an A676C substitution, blaVIM-63. This gene was detected on the chromosome of two carbapenem-resistant clinical strains of Citrobacter freundii ST22 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b697c31fee01af13bfeb975f107ca7
http://hdl.handle.net/10261/306162
http://hdl.handle.net/10261/306162
Autor:
Marta Hernández-García, María García-Castillo, Patricia Ruiz-Garbajosa, Germán Bou, María Siller-Ruiz, Cristina Pitart, Irene Gracia-Ahufinger, Xavier Mulet, Álvaro Pascual, Nuria Tormo, Rafael Cantón
Publikováno v:
Antimicrob Agents Chemother
Novel β-lactam-β-lactamase inhibitor combinations currently approved for clinical use are poorly active against metallo-β-lactamase (MBL)-producing strains. We evaluated the in vitro activity of cefepime-taniborbactam (FTB [formerly cefepime-VNRX-
Autor:
A García-Duque, Fernando Docobo-Pérez, Esther Recacha, Jesús Machuca, Álvaro Pascual, José-Manuel Rodríguez-Martínez, Jesús Blázquez, S Diaz-Diaz
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Suppression of the recA SOS response gene and reactive oxygen species (ROS) overproduction have been shown, separately, to enhance fluoroquinolone activity and lethality. Their putative synergistic impact as a strategy to potentiate the efficacy of b
Autor:
B de Gregorio-Iaria, Álvaro Pascual, Jesús Rodríguez-Baño, Fernando Docobo-Pérez, José-Manuel Rodríguez-Martínez, Jesús Blázquez, I Portillo-Calderón, M Ortiz-Padilla
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Antimicrob Agents Chemother
instname
Antimicrob Agents Chemother
The objectives of this study were to characterize the role of the uhpT, glpT, and fosA genes in fosfomycin resistance in Klebsiella pneumoniae and evaluate the use of sodium phosphonoformate (PPF) in combination with fosfomycin. Seven clinical isolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd80869460577be12ee716fe341022f
http://hdl.handle.net/10261/261962
http://hdl.handle.net/10261/261962
Autor:
Álvaro Pascual, Vicente Merino-Bohórquez, M Ortiz-Padilla, José-Manuel Rodríguez-Martínez, Jesús Rodríguez-Baño, Jesús Blázquez, B de Gregorio-Iaria, I Portillo-Calderón, Fernando Docobo-Pérez
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
We evaluated human-like the efficacy of intravenous doses of fosfomycin of 8 g every 8 h (8 g/Q8h) and of amikacin (15 mg/kg/Q24h) in monotherapy and in combination against six fosfomycin-heteroresistant Escherichia coli isolates using a hollow-fiber
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc22f8d2e979b5792093714303df6cd
http://hdl.handle.net/10261/261954
http://hdl.handle.net/10261/261954
Autor:
Álvaro Pascual, M. C. Conejo, Sarah Whalley, Virginia Ramos-Martin, George L. Drusano, William W. Hope, M. Ballestero-Téllez, José-Manuel Rodríguez-Martínez, Jesús Rodríguez-Baño, Joanne Goodwin, M. Van Guilder, Adam Johnson, Fernando Docobo-Pérez
Publikováno v:
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
instname
The aim of this study was to improve the understanding of the pharmacokinetic-pharmacodynamic relationships of fosfomycin against extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli strains that have different fosfomycin MICs. Our meth
Autor:
Laura Fernandez-Garcia, Antón Ambroa, María M. López, Álvaro Pascual, Rafael López-Rojas, Germán Bou, María Tomás, Lucia Blasco, Felipe Fernández-Cuenca
Publikováno v:
Antimicrobial Agents and Chemotherapy
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
The molecular mechanisms of tolerance and persistence associated with several compounds in Acinetobacter baumannii clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a9275485a2be34f7c3134245c5fd5b
http://hdl.handle.net/10261/184549
http://hdl.handle.net/10261/184549
Autor:
M. S. Ramos-Guelfo, Jesús Machuca, José-Manuel Rodríguez-Martínez, Jesús Blázquez, Esther Recacha, P. Díaz de Alba, Jerónimo Rodríguez-Beltrán, Álvaro Pascual, Fernando Docobo-Pérez
Publikováno v:
mBio
mBio, Vol 8, Iss 5, p e00971-17 (2017)
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
mBio, Vol 8, Iss 5 (2017)
mBio, Vol 8, Iss 5, p e00971-17 (2017)
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
mBio, Vol 8, Iss 5 (2017)
Suppression of the SOS response has been postulated as a therapeutic strategy for potentiating antimicrobial agents. We aimed to evaluate the impact of its suppression on reversing resistance using a model of isogenic strains of Escherichia coli repr
Autor:
Rafael Canton, Jesús Rodríguez-Baño, Isabel Pujol Bajador, Elisenda Miro, Guillermo Ruiz-Carrascoso, Carlos Rodríguez Lucas, Fátima Galán Sánchez, Álvaro Pascual Hernández, Maria de los Angeles Orellana, German Bou, Alejandro Gonzalez Praetorius, Juan José González-López, Mª Carmen Conejo Gonzalo, Jesús Oteo, Luis Martínez Martínez, Maria Perez-Vazquez, Ferran Navarro, Laura Martínez-García, MARTA FERNÁNDEZ-MARTÍNEZ, LAURA ZAMORANO, Marta Mora-Rillo, Jorge J. Cabrera Alvargonzalez, José Manuel Azcona-Gutiérrez
Publikováno v:
Repisalud
Instituto de Salud Carlos III (ISCIII)
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Zaguán. Repositorio Digital de la Universidad de Zaragoza
idUS. Depósito de Investigación de la Universidad de Sevilla
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Instituto de Salud Carlos III (ISCIII)
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Zaguán. Repositorio Digital de la Universidad de Zaragoza
idUS. Depósito de Investigación de la Universidad de Sevilla
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
The aim of this study was to determine the impact of carbapenemase-producing Enterobacteriaceae (CPE) in Spain in 2013 by describing the prevalence, dissemination, and geographic distribution of CPE clones, and their population structure and antibiot