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Publikováno v:
J Virol
Viral antagonism of innate immune pathways is a common mechanism by which viruses evade immune surveillance. Infection of host cells with reovirus leads to the blockade of NF-{kappa}B, a key transcriptional regulator of the hosts innate immune respon
Autor:
Helio S. Sader, Cecilia G Carvalhaes, Mariana Castanheira, Rodrigo E. Mendes, Jennifer M. Streit
Publikováno v:
Antimicrobial Agents and Chemotherapy. 66
Oritavancin displayed potent and stable activity (MIC 90 range of 0.06 to 0.5 mg/L) over a 10-year period (2010 to 2019) against Gram-positive pathogens that cause bloodstream infections (BSI), including methicillin-resistant Staphylococcus aureus (M
Publikováno v:
Antimicrob Agents Chemother
Pseudomonas aeruginosa is a common pathogen that is associated with multidrug-resistant (MDR) and carbapenem-resistant (CR) phenotypes; therefore, we investigated its resistance patterns and mechanisms by using data from the Antimicrobial Testing Lea
Publikováno v:
Antimicrob Agents Chemother
Multidrug-resistant (MDR) Pseudomonas aeruginosa presents a serious threat to public health due to its widespread resistance to numerous antibiotics. P. aeruginosa commonly causes nosocomial infections including urinary tract infections (UTI) which h
Autor:
Abhijit Chowdhury, Simanti Datta, Gopal Krishna Dhali, Filip Kalčic, Saikat Chakrabarti, Soma Banerjee, Rajiv Kumar Mondal, Ayana Baidya, Zlatko Janeba, Mousumi Khatun, Krishna Kumar, Ondřej Baszczyňski, Kausik S. Das
Publikováno v:
J Virol
Nucleos(t)ide analogues entecavir (ETV) and tenofovir disoproxil fumarate (TDF) are recommended as first-line monotherapies for chronic hepatitis B (CHB). Multiple HBV genotypes/subgenotypes have been described, but their impact on treatment response
Autor:
Ruwen Jou, Hulya Simsek, Saijai Smithtikarn, Laima Vasiliauskaitė, Camilla Rodrigues, Rumina Hasan, Phalin Kamolwat, Charoen Chuchottaworn, Beverly Metchock, Koné Kaniga, Edita Vasiliauskienė, Greta Musteikiene, Jirakan Boonyasopun, Mubin Kazi, Catherine Ann Sacopon, Nguyen Viet Nhung, Seungmo Kim, Shaheed V. Omar, Anh Le Thi Ngoc, So Youn Shin, Sabira Tahseen, Skaidrius Miliauskas, Mei-Hua Wu, Nazir Ahmed Ismail
Publikováno v:
Journal of Clinical Microbiology. 60
Bedaquiline Drug Resistance Emergence Assessment in Multidrug-resistant-tuberculosis (MDR-TB) (DREAM) was a 5-year (2015-2019) phenotypic drug-resistance surveillance study across 11 countries. DREAM assessed the susceptibility of 5036 MDR-TB isolate
Publikováno v:
Antimicrob Agents Chemother
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
The failure of antibiotic therapy in respiratory tract infections in cystic fibrosis is partly due to the high tolerance observed in Pseudomonas aeruginosa biofilms. This tolerance is mediated by changes in bacterial metabolism linked to growth in bi
Autor:
Warren E. Rose, Wessam Abdelhady, Richard A. Proctor, Cassandra Lew, Christian K. Lapitan, Nagendra N. Mishra, Arnold S. Bayer
Publikováno v:
Antimicrobial Agents and Chemotherapy. 66
Increased usage of daptomycin (DAP) for methicillin-resistant Staphylococcus aureus (MRSA) infections has led to emergence of DAP-resistant (DAP-R) strains, resulting in treatment failures. DAP-fosfomycin (Fosfo) combinations are synergistically acti
Autor:
Eugene L. Stewart, Mark R. Underwood, Joseph Horton, Michael Aboud, Keith Nangle, Judy Hopking, Kimberly Y. Smith, Ruolan Wang, Brian Wynne, Jörg Sievers
Publikováno v:
Antimicrobial Agents and Chemotherapy
At week 48 in the phase IIIb DAWNING study, the integrase strand transfer inhibitor (INSTI) dolutegravir plus 2 nucleoside reverse transcriptase inhibitors demonstrated superiority to ritonavir-boosted lopinavir in achieving virologic suppression in
Autor:
Melis N. Anahtar, Juliet T Bramante, Douglas S. Kwon, Eric S. Rosenberg, Jiawu Xu, Virginia M. Pierce, Jeffrey M Paer, Lisa Desrosiers
Publikováno v:
Antimicrob Agents Chemother
Background: Enterococcus faecium is a major cause of clinical infections, often due to multidrug-resistant (MDR) strains. Whole genome sequencing (WGS) is a powerful tool to study MDR bacteria and their antimicrobial resistance (AMR) mechanisms. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41eb5a9a4ae8519bc35f8f2e4e21f55a
https://europepmc.org/articles/PMC8765321/
https://europepmc.org/articles/PMC8765321/