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Publikováno v:
J Virol
Viral antagonism of innate immune pathways is a common mechanism by which viruses evade immune surveillance. Infection of host cells with reovirus leads to the blockade of NF-{kappa}B, a key transcriptional regulator of the hosts innate immune respon
Autor:
Helio S. Sader, Cecilia G Carvalhaes, Mariana Castanheira, Rodrigo E. Mendes, Jennifer M. Streit
Publikováno v:
Antimicrobial Agents and Chemotherapy. 66
Oritavancin displayed potent and stable activity (MIC 90 range of 0.06 to 0.5 mg/L) over a 10-year period (2010 to 2019) against Gram-positive pathogens that cause bloodstream infections (BSI), including methicillin-resistant Staphylococcus aureus (M
Publikováno v:
Antimicrob Agents Chemother
Pseudomonas aeruginosa is a common pathogen that is associated with multidrug-resistant (MDR) and carbapenem-resistant (CR) phenotypes; therefore, we investigated its resistance patterns and mechanisms by using data from the Antimicrobial Testing Lea
Publikováno v:
Antimicrob Agents Chemother
Multidrug-resistant (MDR) Pseudomonas aeruginosa presents a serious threat to public health due to its widespread resistance to numerous antibiotics. P. aeruginosa commonly causes nosocomial infections including urinary tract infections (UTI) which h
Autor:
Abhijit Chowdhury, Simanti Datta, Gopal Krishna Dhali, Filip Kalčic, Saikat Chakrabarti, Soma Banerjee, Rajiv Kumar Mondal, Ayana Baidya, Zlatko Janeba, Mousumi Khatun, Krishna Kumar, Ondřej Baszczyňski, Kausik S. Das
Publikováno v:
J Virol
Nucleos(t)ide analogues entecavir (ETV) and tenofovir disoproxil fumarate (TDF) are recommended as first-line monotherapies for chronic hepatitis B (CHB). Multiple HBV genotypes/subgenotypes have been described, but their impact on treatment response
Publikováno v:
Antimicrob Agents Chemother
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
The failure of antibiotic therapy in respiratory tract infections in cystic fibrosis is partly due to the high tolerance observed in Pseudomonas aeruginosa biofilms. This tolerance is mediated by changes in bacterial metabolism linked to growth in bi
Autor:
Warren E. Rose, Wessam Abdelhady, Richard A. Proctor, Cassandra Lew, Christian K. Lapitan, Nagendra N. Mishra, Arnold S. Bayer
Publikováno v:
Antimicrobial Agents and Chemotherapy. 66
Increased usage of daptomycin (DAP) for methicillin-resistant Staphylococcus aureus (MRSA) infections has led to emergence of DAP-resistant (DAP-R) strains, resulting in treatment failures. DAP-fosfomycin (Fosfo) combinations are synergistically acti
Autor:
Harsimran Kaur, Raees A. Paul, Rajeev Soman, Dipali Chavan, Arunaloke Chakrabarti, Parijit Das, Kaustuv Sanyal, Sanjay Bhattacharya, Anup K. Ghosh, Shivaprakash M Rudramurthy, Dipti Sharma, Rajendra Prasad, Shreya Singh, Shamanth A Shankarnarayan, Nisha Kashyap
Publikováno v:
Antimicrob Agents Chemother
Objectives: Echinocandins are frontline antifungal agents in the management of invasive infections due to multi-drug resistant Candida auris. The study aimed to evaluate echinocandin resistance in C. auris isolates of multicentric origin, identify th
Autor:
Tiffany R Keepers, Suzannah M. Schmidt-Malan, Robin Patel, Alisa W Serio, Melissa J. Karau, Bobbi S. Pritt, Surya Chitra, Scott A. Cunningham, Jayawant N. Mandrekar
Publikováno v:
Antimicrobial Agents and Chemotherapy
Omadacycline, vancomycin, and rifampin, as well as rifampin combination therapies, were evaluated in an experimental rat model of methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis. All treatment groups had less MRSA recovered than sali
Autor:
Ting Li, Yaowen Li, Shuaishuai Wang, Na Zhang, Jun Mao, Yisong Yan, Yu Peng, Guang Yang, Yanyan Liu, Xiaohui Huang, Jiabin Li, Huiping Liu, Lifang Jiang
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 3 (2021)
The rapid spread of antibiotic resistance among Enterococcus has prompted considerable interest in determining the dosage regimen of linezolid combined with fosfomycin. A checkerboard assay was employed to evaluate whether linezolid combined with fos