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Publikováno v:
J Virol
Viral antagonism of innate immune pathways is a common mechanism by which viruses evade immune surveillance. Infection of host cells with reovirus leads to the blockade of NF-{kappa}B, a key transcriptional regulator of the hosts innate immune respon
Autor:
Jingshu Ji, Linghong Zhang, Zhongju Chen, Jin Zhu, Yunsong Yu, Han Shen, Qi-Wen Yang, Xiaoting Hua, Qing Yang, Yue Li, Heng Cai, Sebastian Leptihn, Jie Chen, Xi Li, Feng Zhao, Yiwei Zhu
Publikováno v:
mSystems
mSystems, Vol 6, Iss 6 (2021)
mSystems, Vol 6, Iss 6 (2021)
Klebsiella pneumoniae carbapenemase (KPC)-producing Pseudomonas aeruginosa (KPC-PA) has been reported sporadically. However, epidemiological and antimicrobial susceptibility data specific for KPC-PA are lacking. We collected 374 carbapenem-resistant
Publikováno v:
Journal of Bacteriology
In vitro culture media are being developed to understand how host site-specific nutrient profiles influence microbial pathogenicity and ecology. To mimic the cystic fibrosis (CF) lung environment, a variety of artificial sputum media (ASM) have been
Autor:
Alan R. Hauser, Fiorella Krapp, Nathan B. Pincus, Chao Qi, Egon A. Ozer, Katherine R. Murphy, Zackery P. Bulman, Eric Wenzler
Publikováno v:
mSystems
mSystems, Vol 6, Iss 5 (2021)
mSystems, Vol 6, Iss 5 (2021)
Carbapenem-resistant Klebsiella pneumoniae strains cause severe infections that are difficult to treat. The production of carbapenemases such as the K. pneumoniae carbapenemase (KPC) is a common mechanism by which these strains resist killing by the
Autor:
Nirjara Singhvi, Vipin Gupta
Publikováno v:
mSystems
mSystems, Vol 6, Iss 4 (2021)
mSystems, Vol 6, Iss 4 (2021)
Secondary metabolites produced by Actinobacteria are an important source of antibiotics, drugs, and antimicrobial peptides. However, the large genome size of actinobacteria with high gene coding density makes it difficult to understand the complex re
Publikováno v:
mSphere
mSphere, Vol 6, Iss 3 (2021)
mSphere, Vol 6, Iss 3 (2021)
Pseudomonas aeruginosa is a multidrug-resistant, opportunistic pathogen that frequently causes ventilator-associated pneumonia in intensive care units and chronic lung infections in cystic fibrosis patients. The rising prevalence of drug-resistant ba
Publikováno v:
Journal of Bacteriology.
Resistance in VanA-type vancomycin resistant Enterococcus faecium (VREfm) is due to an inducible gene cassette encoding seven proteins ( vanRSHAXYZ ). This provides for an alternative peptidoglycan (PG) biosynthesis pathway whereby d- Alanyl- d- Alan
Autor:
Ørjan Samuelsen, Pål Jarle Johnsen, Hanna-Kirsti S. Leiros, Christopher Fröhlich, Viivi H. A. Hirvonen, Bjarte Aarmo Lund, Marc W. van der Kamp, Klaus Harms, João Alves Gama
Publikováno v:
mSphere
mSphere, Vol 6, Iss 2 (2021)
Fröhlich, C, Hirvonen, V H A & Van Der Kamp, M W 2021, ' Cryptic β-lactamase evolution is driven by low β-lactam concentrations ', mSphere, vol. 6, no. 2, e00108-21 . https://doi.org/10.1128/mSphere.00108-21
mSphere, Vol 6, Iss 2 (2021)
Fröhlich, C, Hirvonen, V H A & Van Der Kamp, M W 2021, ' Cryptic β-lactamase evolution is driven by low β-lactam concentrations ', mSphere, vol. 6, no. 2, e00108-21 . https://doi.org/10.1128/mSphere.00108-21
Very low antibiotic concentrations have been shown to drive the evolution of antimicrobial resistance. While substantial progress has been made to understand the driving role of low concentrations during resistance development for different antimicro
Ceftolozane/Tazobactam Resistance and Mechanisms in Carbapenem-Nonsusceptible Pseudomonas aeruginosa
Autor:
Cheng Yee Tang, Andrea L. Kwa, Rick Twee-Hee Ong, Jie Chong Lim, Si Hui Tan, Jocelyn Qi-Min Teo, Shannon Jing-Yi Lee, James Heng Chiak Sim
Publikováno v:
mSphere, Vol 6, Iss 1 (2021)
mSphere
mSphere
Pseudomonas aeruginosa infection is one of the most difficult health care-associated infections to treat due to the ability of the organism to acquire a multitude of resistance mechanisms and express the multidrug resistance phenotype. Ceftolozane/ta
Autor:
Heiko T. Kiesewalter, Ákos T. Kovács, Tue Sparholt Jørgensen, Vaughn S. Cooper, Tilmann Weber, Carlos N. Lozano-Andrade, Thomas Ostenfeld Larsen, Mario Wibowo, Dan J. Snyder, Mikael Lenz Strube, Gergely Maróti
Publikováno v:
mSystems, Vol 6, Iss 1 (2021)
Kiesewalter, H T, Lozano-Andrade, C N, Wibowo, M, Strube, M L, Maróti, G, Snyder, D, Jørgensen, T S, Larsen, T O, Cooper, V S, Weber, T & Kovács, Á T 2021, ' Genomic and Chemical Diversity of Bacillus subtilis Secondary Metabolites against Plant Pathogenic Fungi ', mSystems, vol. 6, no. 1, e00770-20 . https://doi.org/10.1128/mSystems.00770-20
mSystems
Kiesewalter, H T, Lozano-Andrade, C N, Wibowo, M, Strube, M L, Maróti, G, Snyder, D, Jørgensen, T S, Larsen, T O, Cooper, V S, Weber, T & Kovács, Á T 2021, ' Genomic and Chemical Diversity of Bacillus subtilis Secondary Metabolites against Plant Pathogenic Fungi ', mSystems, vol. 6, no. 1, e00770-20 . https://doi.org/10.1128/mSystems.00770-20
mSystems
Bacillus subtilis produces a wide range of secondary metabolites providing diverse plant growth-promoting and biocontrol abilities. These secondary metabolites include nonribosomal peptides with strong antimicrobial properties, causing either cell ly