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Publikováno v:
Antimicrob Agents Chemother
Background: This risk of vancomycin (VAN)-associated acute kidney injury (AKI) may be altered with combination regimens. The specific AKI risk when VAN is combined with imipenem-cilastatin/relebactam (IMP-C/REL) or piperacillin/tazobactam (TZP) has n
Publikováno v:
Antimicrob Agents Chemother
Augmented renal clearance (ARC) can occur in critically ill pediatric patients receiving aminoglycosides such as gentamicin and tobramycin, yet optimal dosing strategies for ARC are undefined. We evaluated the probability of achieving efficacious or
Autor:
Nicholas J. White, Mara K. N. Lawniczak, Darunee Chiwcharoen, Kathrin Witmer, Arjen M. Dondorp, Kesinee Chotivanich, Oliver J Watson, Virginia M. Howick, Jake Baum, Lucy C Okell, Richard D. Pearson, Michael J. Delves, Andrea Ruecker, Farah A. Dahalan, Boodtee Sornboon, Sasithon Pukrittayakamee, Sabrina Yahiya, Ursula Straschil
Publikováno v:
Antimicrobial Agents and Chemotherapy
Antimicrobial agents and chemotherapy, 65(1):e00898-20. American Society for Microbiology
Antimicrobial agents and chemotherapy, 65(1):e00898-20. American Society for Microbiology
Resistance to artemisinin-based combination therapy (ACT) in the Plasmodium falciparum parasite is threatening to reverse recent gains in reducing global deaths from malaria. While resistance manifests as delayed parasite clearance in patients, the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222babf9a1a4a841550f7ebef07a8dea
https://doi.org/10.1128/aac.00898-20
https://doi.org/10.1128/aac.00898-20
Publikováno v:
Antimicrob Agents Chemother
The aim of this work was to evaluate the pharmacokinetics of amikacin in Mexican patients with different renal functions receiving once-daily dosing regimens and the influence of clinical and demographical covariates that may influence the optimizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f28d58da3a7dceaa6d246c55649896
https://europepmc.org/articles/PMC7449153/
https://europepmc.org/articles/PMC7449153/
Autor:
Richard M. Hoglund, Martha M. Lemnge, Kimberley K Scarsi, Saye Khoo, Stephen Walimbwa, Sunil Parikh, Mohammed Lamorde, Lesley Workman, Karen I. Barnes, Jose Francis, Ifeyinwa Chijioke-Nwauche, Paolo Denti, Colin J. Sutherland, Francesca T. Aweeka, Nyagonde Nyagonde, Joel Tarning, Concepta Merry, Ib C. Bygbjerg, Lasse S Vestergaard, Tamara Kredo, Pauline Byakika-Kibwika
Publikováno v:
Antimicrobial Agents and Chemotherapy
Francis, J, Barnes, K I, Workman, L, Kredo, T, Vestergaard, L S, Hoglund, R M, Byakika-Kibwika, P, Lamorde, M, Walimbwa, S I, Chijioke-Nwauche, I, Sutherland, C J, Merry, C, Scarsi, K K, Nyagonde, N, Lemnge, M M, Khoo, S H, Bygbjerg, I C, Parikh, S, Aweeka, F T, Tarning, J & Denti, P 2020, ' An Individual Participant Data Population Pharmacokinetic Meta-Analysis of Drug-drug Interactions between Lumefantrine and Commonly-used Antiretroviral Treatment ', Antimicrobial Agents and Chemotherapy, vol. 64, no. 5, e02394 . https://doi.org/10.1128/AAC.02394-19
Francis, J, Barnes, K I, Workman, L, Kredo, T, Vestergaard, L S, Hoglund, R M, Byakika-Kibwika, P, Lamorde, M, Walimbwa, S I, Chijioke-Nwauche, I, Sutherland, C J, Merry, C, Scarsi, K K, Nyagonde, N, Lemnge, M M, Khoo, S H, Bygbjerg, I C, Parikh, S, Aweeka, F T, Tarning, J & Denti, P 2020, ' An Individual Participant Data Population Pharmacokinetic Meta-Analysis of Drug-drug Interactions between Lumefantrine and Commonly-used Antiretroviral Treatment ', Antimicrobial Agents and Chemotherapy, vol. 64, no. 5, e02394 . https://doi.org/10.1128/AAC.02394-19
Treating malaria in HIV-coinfected individuals should consider potential drug-drug interactions. Artemether-lumefantrine is the most widely recommended treatment for uncomplicated malaria globally. Lumefantrine is metabolized by CYP3A4, an enzyme tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0399802a363c8c72e12d38fee364a18a
https://researchonline.lshtm.ac.uk/id/eprint/4656336/8/Francis-etal-2020_An_Individual_Participant_Data_Population.pdf
https://researchonline.lshtm.ac.uk/id/eprint/4656336/8/Francis-etal-2020_An_Individual_Participant_Data_Population.pdf
Autor:
Roni Gibori, Arik Dahan, Carmil Azran, Ehud Horwitz, Hila Elinav, Sarah Israel, Daniel Porat, Ram Elazary
Publikováno v:
Antimicrob Agents Chemother
Bariatric surgery is increasingly performed in morbidly obese HIV patients. Limited data exist regarding antiretroviral drug exposure after bariatric surgery. We report a case of a morbidly obese HIV patient who underwent sleeve gastrectomy. Abacavir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0aca6e162e4f6ff0635980c6381985
https://europepmc.org/articles/PMC7179309/
https://europepmc.org/articles/PMC7179309/
Autor:
Junichi Mitsuyama, April Connell, Yoshiko Fukuda, Rosie Jaramillo, Thomas F. Patterson, Nathan P. Wiederhold, Hoja P Patterson, Laura K. Najvar, Marcos Olivo, Gabriel Catano
Publikováno v:
Antimicrob Agents Chemother
The in vitro and in vivo activity of the arylamidine T-2307 against Candida auris was evaluated. T-2307 demonstrated in vitro activity (MIC ranges ≤ 0.008 to 0.015 μg/ml at 50% inhibition; 0.125 to >4 μg/ml at 100% inhibition).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db36e547730c65248c216d02848e07a6
https://europepmc.org/articles/PMC7038306/
https://europepmc.org/articles/PMC7038306/
Autor:
Pascal Chavanet, Sandrine Albac, E Aslangul, Delphine Croisier, N. Anzala, Davy Hayez, D. Bonnot, Delphine Labrousse
Publikováno v:
Antimicrob Agents Chemother
We developed a rat model of methicillin-resistant Staphylococcus epidermidis (MRSE) osteitis without implant to compare the efficacy of vancomycin, linezolid, daptomycin, ceftaroline, and rifampin either alone or in association with rifampin. A clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df3a34c8d47aad35130507155303d590
https://europepmc.org/articles/PMC6985758/
https://europepmc.org/articles/PMC6985758/
Autor:
James M Kidd, David P. Nicolau, Rebecca S. Pettit, Colleen Sakon, Louise-Marie Oleksiuk, Jeffrey J. Cies, Joseph L. Kuti
Publikováno v:
Antimicrob Agents Chemother
Adults with cystic fibrosis (CF) frequently harbor Staphylococcus aureus, which is increasingly antibiotic resistant. Telavancin is a once-daily rapidly bactericidal antibiotic active against methicillin-, linezolid-, and ceftaroline-resistant S. aur
Autor:
Mustapha M. Mustapha, Marissa P. Griffith, Christi L. McElheny, Alina Iovleva, Ryan K. Shields, A. William Pasculle, Yohei Doi, Vaughn S. Cooper, Roberta T. Mettus
Publikováno v:
Antimicrob Agents Chemother
OXA-232 is an OXA-48-group class D β-lactamase that hydrolyzes expanded-spectrum cephalosporins and carbapenems at low levels. Clinical strains producing OXA-232 are sometimes susceptible to carbapenems, making it difficult to identify them in the c