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Autor:
Abhijit Chowdhury, Simanti Datta, Gopal Krishna Dhali, Filip Kalčic, Saikat Chakrabarti, Soma Banerjee, Rajiv Kumar Mondal, Ayana Baidya, Zlatko Janeba, Mousumi Khatun, Krishna Kumar, Ondřej Baszczyňski, Kausik S. Das
Publikováno v:
J Virol
Nucleos(t)ide analogues entecavir (ETV) and tenofovir disoproxil fumarate (TDF) are recommended as first-line monotherapies for chronic hepatitis B (CHB). Multiple HBV genotypes/subgenotypes have been described, but their impact on treatment response
Autor:
Eugene L. Stewart, Mark R. Underwood, Joseph Horton, Michael Aboud, Keith Nangle, Judy Hopking, Kimberly Y. Smith, Ruolan Wang, Brian Wynne, Jörg Sievers
Publikováno v:
Antimicrobial Agents and Chemotherapy
At week 48 in the phase IIIb DAWNING study, the integrase strand transfer inhibitor (INSTI) dolutegravir plus 2 nucleoside reverse transcriptase inhibitors demonstrated superiority to ritonavir-boosted lopinavir in achieving virologic suppression in
Autor:
Michael A. Parniak, Philip R. Tedbury, Stefan G. Sarafianos, Aaron B. Reeve, Eva Nagy, Tatiana V Ilina, Maria E. Cilento, Eleftherios Michailidis, Hiroaki Mitsuya
Publikováno v:
Antimicrob Agents Chemother
4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA, MK-8591, islatravir) is a nucleoside reverse transcriptase translocation inhibitor (NRTTI) with exceptional potency against wild-type (WT) and drug-resistant HIV-1 in phase III clinical trials. EFdA re
Autor:
Ernest Asante-Appiah, Dongmei Yang, Elizabeth Martin, Peter Sklar, Christos J. Petropoulos, Jay A. Grobler, Johnny Lai, Daria J. Hazuda, Charles M Walworth, Hong Wan
Publikováno v:
Antimicrobial Agents and Chemotherapy
Clinical management of human immunodeficiency virus type-1 (HIV-1) infection may be negatively impacted by either acquired or transmitted drug resistance. Here, we aim to extend our understanding of the impact of resistance-associated mutations (RAMs
Autor:
Andrew D. Badley, Caitlin J. VanLith, Anisha Misra, Sekar Natesampillai, Ashton Krogman, Aswath P. Chandrasekar, Alecia Alto, F. N.U. Shweta, Nathan W. Cummins, Joseph D. Yao
Publikováno v:
J Virol
The antiapoptotic protein BCL2 inhibits death of HIV-infected cells. Previously, we showed that the BCL2 inhibitor venetoclax selectively kills acutely HIV-infected cells and reduces HIV DNA in latently infected CD4 T cells ex vivo after reactivation
Autor:
Qinzhe Liu, Jiangbo Wei, Sadeem Ahmad, Mark E. Peeples, Amit Sharma, Jianrong Li, Elizabeth L. Kairis, Chuan He, Youling Gao, Dominique Garcin, Sun Hur, Mijia Lu, Miaoge Xue, Yuexiu Zhang, Hai-Tao Wang, Zijie Zhang
Publikováno v:
J Virol
N(6)-Methyladenosine (m(6)A) is the most abundant internal RNA modification catalyzed by host RNA methyltransferases. As obligate intracellular parasites, many viruses acquire m(6)A methylation in their RNAs. However, the biological functions of vira
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4277b6116ba87e52e2607f849e50b16
https://europepmc.org/articles/PMC8104112/
https://europepmc.org/articles/PMC8104112/
Autor:
Wenjiao Wu, Shuyin Gu, Shuwen Liu, Qiao Zhang, Yingyuan Zhong, Lizhu Chen, Yilu Ye, Qi Huang, Mingkai Feng
Publikováno v:
J Virol
Guanylate-binding protein 7 (GBP7) belongs to the GBP family, which plays key roles in mediating innate immune responses to intracellular pathogens. Thus far, GBP7 has been reported to be a critical cellular factor against bacterial infection. Howeve
Autor:
Yasushi Itoh, Hiroyuki Osaka, Yoshihiro Sakoda, Kazumasa Ogasawara, Hirohito Ishigaki, Akihiro Shibata, Ayako Ogata-Nakahara, Masatoshi Okamatsu, Cong Thanh Nguyen, Saori Suzuki, Hiroshi Kida
Publikováno v:
Antimicrob Agents Chemother
H7N9 highly pathogenic avian influenza virus (HPAIV) infection in a human was first reported in 2017. A/duck/Japan/AQ-HE29-22/2017 (H7N9) (Dk/HE29-22), found in imported duck meat at an airport in Japan, possesses a hemagglutinin with a multibasic cl
Publikováno v:
Antimicrob Agents Chemother
Polyomavirus-related infections are ubiqutious in immunocompromised individuals and in some cases are intractable and fatal. Due to lack of approved drugs to treat polyomavirus infections, cidofovir, a phosphonate nucleotide analog approved to treat
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
mBio
mBio
While resistance to antiviral drugs can hinder their clinical use, understanding resistance mechanisms can illuminate how these drugs and their targets act. We studied a substitution in the human cytomegalovirus (HCMV) DNA polymerase that confers res