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Publikováno v:
Journal of Bacteriology
In vitro culture media are being developed to understand how host site-specific nutrient profiles influence microbial pathogenicity and ecology. To mimic the cystic fibrosis (CF) lung environment, a variety of artificial sputum media (ASM) have been
Autor:
Yili Xu, Brian E. Schultz, Daniel Soohoo, Raju Subramanian, John P. Bilello, Ruidong Li, Darius Babusis, Jingyu Zhang, Cynthia Kim, Eisuke Murakami, Bill J. Smith, Jing Zou, Qin Yue, Roman Sakowicz, Congrong Niu, Joy Y. Feng, Jared Pitts, Li Li, Bin Ma, Xiaofeng Zhao, Xuping Xie, Bernard P. Murray, Albert Liclican, Pei Yong Shi
Publikováno v:
Antimicrobial Agents and Chemotherapy
Remdesivir (RDV; GS-5734, Veklury), the first FDA-approved antiviral to treat COVID-19, is a single-diastereomer monophosphoramidate prodrug of an adenosine analogue. RDV is taken up in the target cells and metabolized in multiple steps to form the a
Autor:
Daisuke Hagiwara, Hiroki Takahashi, Yoko Kusuya, Mio Sato, Kenji Onishi, Takahito Toyotome, Akira Watanabe
Publikováno v:
Antimicrob Agents Chemother
Azole resistance of Aspergillus fumigatus is a global problem. The major resistant mechanism is a cyp51A alteration such as mutation(s) in the gene and the acquisition of a tandem repeat in the promoter. Although other azole tolerances and resistant
Autor:
Jia Chen, Weiqin Chen, Guanyi Zhang, Zhen Li, Dongting Yao, Hongmei Yin, Xiaobo Hu, Xin Zheng
Publikováno v:
Antimicrobial Agents and Chemotherapy. 65
Candida glabrata is currently the first or second most commonly encountered non-albicans Candida species worldwide. The potential severity of Candida resistance mandates the discovery of novel antifungal agents, including those that can be used in co
Autor:
Nathan P. Wiederhold, Thomas F. Patterson, Marcos Olivo, Hoja P Patterson, Gabriel Catano, Laura K. Najvar, Kelsey N Morris
Publikováno v:
Antimicrobial Agents and Chemotherapy. 65
Candida auris is an emerging pathogen that has rapidly spread to many countries on multiple continents. Invasive infections caused by this species are associated with significant mortality, and treatment options are limited due to antifungal resistan
Autor:
Yihua Chen, Xianyun Sun, Huang Jun, Xueyan Yao, Shaojie Li, Hongwei Liu, Zhenying Zhang, Shiping Wei
Publikováno v:
Applied and Environmental Microbiology. 87
Diseases caused by soilborne fungal pathogens result in significant crop yield losses and quality reduction. Streptomyces albidoflavus strain W68 is effective in controlling several soilborne fungal diseases. To identify antifungal substances critica
Autor:
Yang Yang, Shanshan Li, Fanda Pan, Mingjie Shen, Linlin Xie, Jun Li, Guoqing Chen, Robert J. Linhardt, Weihong Zhong, Fuming Zhang, Jiao Yang, Ming Shu
Publikováno v:
Applied and Environmental Microbiology. 87
Nicotine and nicotinic acid (NA) are both considered to be representatives of N-heterocyclic aromatic compounds, and their degradation pathways have been revealed in Pseudomonas species. However, the cooccurrence of these two pathways has only been o
Autor:
Heiko T. Kiesewalter, Ákos T. Kovács, Tue Sparholt Jørgensen, Vaughn S. Cooper, Tilmann Weber, Carlos N. Lozano-Andrade, Thomas Ostenfeld Larsen, Mario Wibowo, Dan J. Snyder, Mikael Lenz Strube, Gergely Maróti
Publikováno v:
mSystems, Vol 6, Iss 1 (2021)
Kiesewalter, H T, Lozano-Andrade, C N, Wibowo, M, Strube, M L, Maróti, G, Snyder, D, Jørgensen, T S, Larsen, T O, Cooper, V S, Weber, T & Kovács, Á T 2021, ' Genomic and Chemical Diversity of Bacillus subtilis Secondary Metabolites against Plant Pathogenic Fungi ', mSystems, vol. 6, no. 1, e00770-20 . https://doi.org/10.1128/mSystems.00770-20
mSystems
Kiesewalter, H T, Lozano-Andrade, C N, Wibowo, M, Strube, M L, Maróti, G, Snyder, D, Jørgensen, T S, Larsen, T O, Cooper, V S, Weber, T & Kovács, Á T 2021, ' Genomic and Chemical Diversity of Bacillus subtilis Secondary Metabolites against Plant Pathogenic Fungi ', mSystems, vol. 6, no. 1, e00770-20 . https://doi.org/10.1128/mSystems.00770-20
mSystems
Bacillus subtilis produces a wide range of secondary metabolites providing diverse plant growth-promoting and biocontrol abilities. These secondary metabolites include nonribosomal peptides with strong antimicrobial properties, causing either cell ly
Publikováno v:
Antimicrob Agents Chemother
Nitrofurantoin (NIT) is a broad-spectrum bactericidal antibiotic used in the treatment of urinary tract infections. It is a pro-drug that once activated by nitroreductases goes on to inhibit bacterial DNA, RNA, cell wall, and protein synthesis. Previ
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
mBio
mBio
While resistance to antiviral drugs can hinder their clinical use, understanding resistance mechanisms can illuminate how these drugs and their targets act. We studied a substitution in the human cytomegalovirus (HCMV) DNA polymerase that confers res