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Publikováno v:
J Virol
Interactions between the N-terminal (assembly) domain (NTD) and the linker region of the hepatitis B virus (HBV) capsid protein and the large (L) envelope protein are required for virion formation, which occurs via budding of cytoplasmic mature nucle
Autor:
Eric A. Weaver, Zhigang Wang, Brianna L. Bullard, Clinton Jones, Amber B Rico, Annabel T Olson, Alexandria C Linville, Matthew S. Wiebe
Publikováno v:
Journal of Virology. 93
Comparative examination of viral and host protein homologs reveals novel mechanisms governing downstream signaling effectors of both cellular and viral origin. The vaccinia virus B1 protein kinase is involved in promoting multiple facets of the virus
Publikováno v:
mBio
mBio, Vol 10, Iss 4, p e01428-19 (2019)
mBio, Vol 10, Iss 4 (2019)
mBio, Vol 10, Iss 4, p e01428-19 (2019)
mBio, Vol 10, Iss 4 (2019)
The ability of mammalian cells to detect the genomes of nuclear-replicating viruses via cellular DNA sensors is fundamental to innate immunity. Recently, mounting evidence is supporting the universal role of polymerization in these host defense facto
Autor:
Stefan Tenzer, Steffi Krauter, Bodo Plachter, Nadine Krämer, Elisabeth Sehn, Christine Zimmermann, Uwe Wolfrum, Nicole Büscher
Publikováno v:
Journal of Virology. 92
The tegument of human cytomegalovirus (HCMV) virions contains proteins that interfere with both the intrinsic and the innate immunity. One protein with a thus far unknown function is pUL25. The deletion of pUL25 in a viral mutant (Towne-ΔUL25) had n
Publikováno v:
Journal of Virology. 90:7205-7218
The hepatitis C virus NS5A protein is tethered to cellular membranes via an amphipathic amino-terminal helix that is inserted in-plane into the outer endoplasmic reticulum (ER)-derived membrane leaflet. The charged face of the helix faces the cytopla
Autor:
Masahiro Yamashita, Brittany N. Dubose, Namiko Saito, Samantha Teng, Theodora Hatziioannou, Saumendra Prasad Roy, Jing Huang, Matthew S. Henning, Alan Engelman, Mohammad Adnan Siddiqui, Erik Serrao, Xiangming Li, Akatsuki Saito, Jinwoo Ahn, Moriya Tsuji
Publikováno v:
Journal of Virology. 90:6918-6935
Cleavage and polyadenylation specificity factor subunit 6 (CPSF6), a host factor that interacts with the HIV-1 capsid (CA) protein, is implicated in diverse functions during the early part of the HIV-1 life cycle, including uncoating, nuclear entry,
Autor:
Li-Hsin Li, Ee-Hong Tam, Sue-Jane Lin, Rei-Lin Kuo, Yu-Nong Gong, Guang-Wu Chen, Zong-Hua Li, Robert M. Krug, Shin-Ru Shih, Cheng-Kai Chang, Yi-Ren Wang
The NS1 protein encoded by influenza A virus antagonizes the interferon response through various mechanisms, including blocking cellular mRNA maturation by binding the cellular CPSF30 3′ end processing factor and/or suppressing the activation of in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056cde22fdd1f4544c41594f4e4f2ff7
https://europepmc.org/articles/PMC4836362/
https://europepmc.org/articles/PMC4836362/
Autor:
Stuart J. D. Neil, Raphael Vigan
Publikováno v:
Journal of Virology. 84:12958-12970
Tetherin (BST2/CD317) potently restricts the particle release of human immunodeficiency virus type 1 (HIV-1) mutants defective in the accessory gene vpu . Vpu antagonizes tetherin activity and induces its cell surface downregulation and degradation i
Publikováno v:
Journal of Virology. 84:2585-2596
Human cytomegalovirus (HCMV) depends upon a five-protein complex, gH/gL/UL128-131, to enter epithelial and endothelial cells. A separate HCMV gH/gL-containing complex, gH/gL/gO, has been described. Our prevailing model is that gH/gL/UL128-131 is requ
Publikováno v:
Molecular and Cellular Biology. 26(6):2160-2174
Several Nox family NADPH oxidases function as multicomponent enzyme systems. We explored determinants of assembly of the multicomponent oxidases Nox1 and Nox3 and examined the involvement of Rac1 in their regulation. Both enzymes are supported by p47