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Publikováno v:
Journal of Virology. 92
Human cytomegalovirus (HCMV) infects a wide variety of human cell types by different entry pathways that involve distinct envelope glycoprotein complexes that include gH/gL, a trimer complex consisting of gHgL/gO, and a pentamer complex consisting of
Publikováno v:
Infection and Immunity. 86
Interleukin-36 (IL-36) cytokines are important regulators of mucosal homeostasis and inflammation. We have previously established that oral epithelial cells upregulate IL-36γ expression in response to the bacterial pathogen Porphyromonas gingivalis.
Autor:
Yolanda Calle, Volker Behrends, Luis M. Mateos, Natalia Bravo-Santano, James K. Ellis, Hector C. Keun, Michal Letek
Publikováno v:
mSphere, Vol 3, Iss 4 (2018)
mSphere, Vol 3, Iss 4, p e00374-18 (2018)
mSphere
mSphere, Vol 3, Iss 4, p e00374-18 (2018)
mSphere
Staphylococcus aureus escapes from immune recognition by invading a wide range of human cells. Once the pathogen becomes intracellular, the most important last resort antibiotics are not effective. Therefore, novel anti-infective therapies against in
Autor:
Bruno Baron, Philippe J. Sansonetti, Gyanendra P. Dubey, Mariano Dellarole, Armelle Phalipon, Fatoumata Samassa, Claude Parsot, Katja Brunner, Laurie Pinaud, Ilia Belotserkovsky, Alexander Rouvinski
Publikováno v:
mBio, Vol 9, Iss 1 (2018)
mBio
mBio, 2018, 9 (1), pp.e02309-17. ⟨10.1128/mBio.02309-17⟩
mBio, American Society for Microbiology, 2018, 9 (1), pp.e02309-17. ⟨10.1128/mBio.02309-17⟩
mBio, Vol 9, Iss 1, p e02309-17 (2018)
mBio
mBio, 2018, 9 (1), pp.e02309-17. ⟨10.1128/mBio.02309-17⟩
mBio, American Society for Microbiology, 2018, 9 (1), pp.e02309-17. ⟨10.1128/mBio.02309-17⟩
mBio, Vol 9, Iss 1, p e02309-17 (2018)
Direct interactions between bacterial and host glycans have been recently reported to be involved in the binding of pathogenic bacteria to host cells. In the case of Shigella, the Gram-negative enteroinvasive bacterium responsible for acute rectocoli
Publikováno v:
Journal of Virology. 89:6673-6684
Dynasore, a small-molecule inhibitor of the GTPase activity of dynamin, inhibits the entry of several viruses, including herpes simplex virus (HSV), but its impact on other steps in the viral life cycle has not been delineated. The current study was
Publikováno v:
Journal of Virology. 89:4668-4675
The life cycle of human papillomaviruses (HPVs) is dependent upon differentiation of the infected host epithelial cell as well as activation of the ataxia telangiectasia mutated (ATM) DNA repair pathway that in normal cells acts to repair double-stra
Autor:
Ravi Jotwani, Himabindu Vuddaraju, Shuang Liang, Huizhi Wang, Huaxin Zhou, Xiaoxian Duan, Richard J. Lamont, David A. Scott
Publikováno v:
Infection and Immunity. 82:4118-4126
Pathogen-induced reactive oxygen species (ROS) play a crucial role in host innate immune responses through regulating the quality and quantity of inflammatory mediators. However, the underlying molecular mechanisms of this effect have yet to be clari
Autor:
Pablo A. González, Betsy C. Herold, Eliseo A. Eugenin, Natalia Cheshenko, William R. Jacobs, Janie B Trepanier
Publikováno v:
Journal of Virology. 88:10026-10038
Herpes simplex virus (HSV) entry requires multiple interactions at the cell surface and activation of a complex calcium signaling cascade. Previous studies demonstrated that integrins participate in this process, but their precise role has not been d
Publikováno v:
Journal of Virology. 87:3261-3270
Interferons (IFNs) are a critical component of the first line of antiviral defense. The activation of Toll-like receptors (TLRs) expressed by dendritic cells triggers different signaling cascades that result in the production of large amounts of IFNs
Autor:
John Scott Wilbur, Giovanna Martinez, Gayatri Vedantam, V. K. Viswanathan, Jennifer Lising Roxas, Xiangfeng Zhang
Publikováno v:
Infection and Immunity. 80:3850-3857
The diarrheagenic pathogen enteropathogenic Escherichia coli (EPEC) limits the death of infected enterocytes early in infection. A number of bacterial molecules and host signaling pathways contribute to the enhanced survival of EPEC-infected host cel