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Publikováno v:
J Virol
Interactions between the N-terminal (assembly) domain (NTD) and the linker region of the hepatitis B virus (HBV) capsid protein and the large (L) envelope protein are required for virion formation, which occurs via budding of cytoplasmic mature nucle
Autor:
Zhenzhen Wang, Huijun Lu, Feng Gao, Jiyu Guan, Kui Zhao, Wenqi He, Lijun Lv, Yungang Lan, Zi Li, Yanlong Zhou, Mengshi Xu, Deguang Song, Hongbin He, Pin Lv
Publikováno v:
Journal of Virology
Orf virus (ORFV) is a highly epitheliotropic parapoxvirus with zoonotic significance that induces proliferative lesions in the skin of sheep, goats, and humans. Several viral proteins carried by ORFV, including nuclear factor-κB (NF-κB) inhibitors,
Publikováno v:
mBio
mBio, Vol 12, Iss 2 (2021)
mBio, Vol 12, Iss 2 (2021)
Viruses, including human cytomegalovirus (HCMV), reprogram cellular metabolism using host metabolic regulators to support virus replication. Alternatively, in response to infection, the host can use metabolism to limit virus replication.
Human c
Human c
Autor:
Wenjiao Wu, Shuyin Gu, Shuwen Liu, Qiao Zhang, Yingyuan Zhong, Lizhu Chen, Yilu Ye, Qi Huang, Mingkai Feng
Publikováno v:
J Virol
Guanylate-binding protein 7 (GBP7) belongs to the GBP family, which plays key roles in mediating innate immune responses to intracellular pathogens. Thus far, GBP7 has been reported to be a critical cellular factor against bacterial infection. Howeve
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
mBio
mBio
High-risk human papillomaviruses (HPVs) infect epithelial cells and induce viral genome amplification upon differentiation. HPV proteins activate DNA damage repair pathways by inducing high numbers of DNA breaks in both viral and cellular DNAs.
Autor:
Lisbeth Drozd Lund, Payal P.S. Balraadjsing, Yuri Souwer, Sebastian A. J. Zaat, Esther C. de Jong, Hanne Frøkiær
Publikováno v:
Infection and immunity, 88(1). American Society for Microbiology
Infect Immun
Infect Immun
Staphylococcus aureus has evolved different strategies to evade the immune response, which play an important role in its pathogenesis. The bacteria express and shed various cell wall components and toxins during different stages of growth that may af
Autor:
Eric A. Weaver, Zhigang Wang, Brianna L. Bullard, Clinton Jones, Amber B Rico, Annabel T Olson, Alexandria C Linville, Matthew S. Wiebe
Publikováno v:
Journal of Virology. 93
Comparative examination of viral and host protein homologs reveals novel mechanisms governing downstream signaling effectors of both cellular and viral origin. The vaccinia virus B1 protein kinase is involved in promoting multiple facets of the virus
Publikováno v:
mSphere, Vol 4, Iss 3, p e00077-19 (2019)
mSphere, Vol 4, Iss 3 (2019)
mSphere
mSphere, Vol 4, Iss 3 (2019)
mSphere
Nearly half a million deaths were attributed to malaria in 2017. Protozoan parasites of the genus Plasmodium cause disease in humans while replicating asexually within the host’s erythrocytes, with P. falciparum responsible for most of the mortalit
Autor:
Yina Zhang, Jiyong Zhou, Liuyuan Shi, Xiran Peng, Xiaojuan Zheng, Yahui Li, Boli Hu, Huansheng Wu, Tuyuan Zheng
Publikováno v:
Journal of Virology
Avibirnavirus protein VP1, the RNA-dependent RNA polymerase, is responsible for IBDV genome replication, gene expression, and assembly. However, little is known about its chemical modification relating to its polymerase activity. In this study, we re
Publikováno v:
Journal of Virology. 92
Herpes simplex virus 2 (HSV-2) can productively infect many different cell types of human and nonhuman origin. Here we demonstrate interconnected roles for two host enzymes, heparanase (HPSE) and cathepsin L, in HSV-2 release from cells. In vaginal e