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pro vyhledávání: '"59"'
Autor:
Thomas F. Patterson, Gabriel Catano, Mike Birch, Derek Law, Laura K. Najvar, John H. Rex, Marcos Olivo, Nathan P. Wiederhold, Rosie Jaramillo
Publikováno v:
Antimicrobial Agents and Chemotherapy. 62
Olorofim (formerly F901318) is an advanced analog of the orotomide class that inhibits fungal pyrimidine biosynthesis. We evaluated the in vitro and in vivo activities of olorofim against Coccidioides species. In vitro activity was assessed against 5
Publikováno v:
Antimicrobial Agents and Chemotherapy. 62
Data are needed from outpatient settings to better inform antimicrobial stewardship. In this study, a random sample of outpatient antibiotic prescriptions by primary care providers (PCPs) at our health care system was reviewed and compared to consens
Autor:
Jay N. Lozier, Jomy M. George, Anela Kellogg, Colleen Hadigan, Khanh Nghiem, Kristina M Brooks, Parag Kumar, Scott R. Penzak, Raul M. Alfaro, Lori A. Gordon, Maryellen McManus
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
Dabigatran etexilate (DE) is a P-glycoprotein (P-gp) probe substrate, and its active anticoagulant moiety, dabigatran, is a substrate of the multidrug and toxin extrusion protein-1 (MATE-1) transporter. The antiretroviral pharmacokinetic enhancers, r
Autor:
Uwe Hahn, Michael S. Roberts, Jason A. Roberts, Fekade B. Sime, Sandra L. Peake, Jeffrey Lipman, Morgyn S. Warner, Ing Soo Tiong
Changes in the pharmacokinetics of piperacillin in febrile neutropenic patients have been reported to result in suboptimal exposures. This study aimed to develop a population pharmacokinetic model for piperacillin and perform dosing simulation to des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72531b13416062580d3e9306a7dcc0e7
https://europepmc.org/articles/PMC5655099/
https://europepmc.org/articles/PMC5655099/
Autor:
Sampson Antwi, Antoinette Orstin, Theresa Opoku, Anthony Enimil, Lubbe Wiesner, Daniel Ansong, Fizza S. Gillani, Dennis Bosomtwe, Charles A. Peloquin, Hongmei Yang, Jennifer Norman, Albert Dompreh, Awewura Kwara, Anima Sarfo
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
Although human immunodeficiency virus (HIV) coinfection is the most important risk factor for a poor antituberculosis (anti-TB) treatment response, its effect on the pharmacokinetics of the first-line drugs in children is understudied. This study exa
Autor:
Maya Hites, Frédéric Cotton, Jean Louis Vincent, Frédérique Jacobs, Marjorie Beumier, Jacques Creteur, Stefano Cristallini, Fabio Silvio Taccone, Hakim Kabtouri, Jason A. Roberts, Jeffrey Lipman
Despite the development of new agents with activity against Gram-positive bacteria, vancomycin remains one of the primary antibiotics for critically ill septic patients. Because sepsis can alter antimicrobial pharmacokinetics, the development of an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319f8f92e27b86724c0f92c1b9be7406
https://europepmc.org/articles/PMC4958221/
https://europepmc.org/articles/PMC4958221/