Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Anna Mae Diehl"'
Publikováno v:
JCI Insight, Vol 5, Iss 22 (2020)
Adult liver has enormous regenerative capacity; it can regenerate after losing two-thirds of its mass while sustaining essential metabolic functions. How the liver balances dual demands for increased proliferative activity with maintenance of organ f
Externí odkaz:
https://doaj.org/article/dcda33acc6254bc694933c95496be6d5
Autor:
Tianyi Chen, Jeongeun Hyun, Ali Ahmadi, Hidekazu Tsukamoto, Zhaoli Sun, Kuo Du, Ullas V. Chembazhi, Anna Mae Diehl, Ivan Rusyn, Sushant Bangru, Auinash Kalsotra
Publikováno v:
J Clin Invest
Severe alcoholic hepatitis (SAH) is a deadly liver disease without an effective medical therapy. Although SAH mortality is known to correlate with hepatic accumulation of immature liver cells, why this occurs and how it causes death are unclear. Here
Autor:
Jun Zhang, Roger J. Davis, Meng Li, Christopher Q. Chen, Anna Mae Diehl, Mariam Aghajan, Ying Wang, Robert Win Maw Min, Tin Aung Than, Sanda Win, Neil Kaplowitz, Yibu Chen, Manal F. Abdelmalek, Filbert W.M. Aung, Ayako Suzuki
Publikováno v:
Journal of Clinical Investigation. 129:5278-5293
SH3 domain–binding protein that preferentially associates with Btk (SAB) is an outer-membrane docking protein for JNK-mediated impairment of mitochondrial function. Deletion of Sab in hepatocytes inhibits sustained JNK activation and cell death. Th
Publikováno v:
Journal of Clinical Investigation. 128:2192-2193
The liver's extraordinary ability to regenerate has been known since the myth of Prometheus, but the mechanisms involved are still being discovered. Various small animal models have been used in this quest. Two of the most popular include partial hep
Publikováno v:
Journal of Clinical Investigation. 123:115-117
In response to feeding, insulin promotes the uptake of sugar in peripheral tissues and suppresses the production of sugar, a process called gluconeogenesis, in the liver. Recent research has shown that chronic inflammation promotes insulin resistance
Autor:
Richard T. Premont, Leandi Krüger, Guanhua Xie, Daniel Metzger, Gamze Karaca, Liu Yang, Steve S. Choi, Gregory A. Michelotti, Marzena Swiderska, Anna Mae Diehl, Wing-Kin Syn
Publikováno v:
Journal of Clinical Investigation.
When regenerative processes cannot keep pace with cell death, functional epithelia are replaced by scar. Scarring is characterized by both excessive accumulation of fibrous matrix and persistent outgrowth of cell types that accumulate transiently dur
Autor:
Anna Mae Diehl, Janice Jou
Epithelial-mesenchymal transitions (EMTs) are believed to play a role in invasion and metastasis of many types of tumors. In this issue of the JCI, Chen et al. show that a gene that has been associated with aggressive biology in hepatocellular carcin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f762387c021f970de796bbf21825c14d
https://europepmc.org/articles/PMC2846072/
https://europepmc.org/articles/PMC2846072/