Zobrazeno 1 - 10
of 53
pro vyhledávání: '"11"'
Autor:
Matthew K. Siggins, Wafa Khamri, Thomas O’Connor, Evangelos Triantafyllou, Mark Thursz, Marie-Anne Mawhin, Mark J. W. McPhail, Hannah C. Husbyn, Kevin J. Woollard, Sujit Mukherjee, Marina Botto, Cathrin Gudd, Robert D. Goldin, Christine Bernsmeier, Charalambos G. Antoniades, Lucia A. Possamai, Francesca M. Trovato, Julia Wendon, Hiromi Kudo
Publikováno v:
The Journal of Clinical Investigation
Patients with acute liver failure (ALF) have systemic innate immune suppression and increased susceptibility to infections. Programmed cell death 1 (PD-1) expression by macrophages has been associated with immune suppression during sepsis and cancer.
Autor:
Eric Finnemore, C. Magnus Sköld, Maurizio Chioccioli, Xiting Yan, Maor Sauler, Isabel S. Bazan, Jose L. Gomez, Åsa M. Wheelock, Clemente J. Britto, Joann B. Sweasy, Feng Wan, Chuanxing Li, Willy Roque, Veronique Neumeister, Qile Dai, Ranjit S. Bindra, Patty J. Lee, Jessica Nouws, Naftali Kaminski, So-Jin Kim
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 2 (2021)
JCI Insight, Vol 6, Iss 2 (2021)
The pathogenesis of chronic obstructive pulmonary disease (COPD) involves aberrant responses to cellular stress caused by chronic cigarette smoke (CS) exposure. However, not all smokers develop COPD and the critical mechanisms that regulate cellular
Autor:
Mathieu Latreille, Markus Stoffel, Emanuel Gasser, Mary P. LaPierre, Yinjie Yang, Kashan Ahmed, Jukka Kero, Thomas Rülicke, Rémy Denzler
MicroRNAs (miRNAs) are negative modulators of gene expression that fine-tune numerous biological processes. miRNA loss-of-function rarely results in highly penetrant phenotypes, but rather, influences cellular responses to physiologic and pathophysio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166ef484bd5a2f3e65b1e0c004c4c3bd
http://hdl.handle.net/10044/1/44431
http://hdl.handle.net/10044/1/44431
Autor:
Mathias Heikenwalder, Maike Sander, Jorge Ferrer, Fabian Geisler, S Dürl, Julian Thalhammer, Petia Jeliazkova, Roland M. Schmid, S Jörs, Marc Ringelhan, Jens T. Siveke
Publikováno v:
J. Clin. Invest. 125, 2445-2457 (2015)
Ductular reactions (DRs) are observed in virtually all forms of human liver disease; however, the histogenesis and function of DRs in liver injury are not entirely understood. It is widely believed that DRs contain bipotential liver progenitor cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6d62d12210411ee0eb7bf579be38af
http://hdl.handle.net/10044/1/35969
http://hdl.handle.net/10044/1/35969
Autor:
Keiichi Ozono, Soji Kasayama, Takuya Yamamoto, Kosei Yoh, Shintaro Okada, Tadamitsu Kishimoto, Toshimi Michigami, M Takagi, Kanji Yamaoka, Sayuri Matsumoto, K Hiroshima
Publikováno v:
Journal of Clinical Investigation. 98:30-35
McCune-Albright syndrome (MAS) is characterized by café-au-lait spot, multiple endocrine hyperfunction, and polyostotic fibrous dysplasia. A somatic point mutation of Gsalpha protein was reported to decrease GTPase activity, leading to increase in t
Autor:
Jerome Niquet, Claude G. Wasterlain
Programmed cell death pathways have been implicated in the mechanism by which neurons die following brief and prolonged seizures, but the significance of proapoptotic Bcl-2 family proteins in the process remains poorly defined. Expression of the deat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d6900980165e7267bff81e6cdddec6
https://europepmc.org/articles/PMC379331/
https://europepmc.org/articles/PMC379331/
Autor:
Stephen J. Haggarty, Roy H. Perlis, Jacob M. Hooker, Baileigh G. Hightower, Minhae Kim, Tonya M. Gilbert, Anisha Bhanot, Joshua L. Roffman, Marco L. Loggia, Hsiao-Ying Wey, Thomas M. Morin, Changning Wang, Frederick A. Schroeder, Daphne J. Holt, Daniel S. Albrecht, Kamber L. Hart, Nicole R. Zürcher, Steven M. Stufflebeam, Amelia M. Pellegrini, Hannah E. Brown, Misha M. Riley, Anais Rodriguez-Thompson, Christine J. Wu
Publikováno v:
Journal of Clinical Investigation. 129:364-372
BACKGROUND. Patients with schizophrenia (SCZ) experience chronic cognitive deficits. Histone deacetylases (HDACs) are enzymes that regulate cognitive circuitry; however, the role of HDACs in cognitive disorders, including SCZ, remains unknown in huma
Autor:
S. Lee Adamson
Publikováno v:
Journal of Clinical Investigation. 124:4690-4692
In a group of 24 peri-operative patients, all received total parenteral nutrition support (artificial gut support) for 11 days using a mixed energy source (50% from glucose and 50% from liposyn-2/intralipid). Intralipid was used in the fat clearance.
Autor:
Alexandre V. Hirayama, Damian J. Green, Terry Stevens-Ayers, Joshua A. Hill, Andrew J. Cowan, Justin J. Taylor, Joyce Maalouf, Laurel Joncas-Schronce, Carla S Walti, Jacob Keane-Candib, Elizabeth M Krantz, Jim Boonyaratanakornkit, Michael Boeckh, Rebecca Gardner, Merav Bar, Cameron J. Turtle, David G. Maloney, Sayan Dasgupta
Publikováno v:
JCI Insight
BACKGROUND Little is known about pathogen-specific humoral immunity after chimeric antigen receptor–modified T (CAR-T) cell therapy for B cell malignancies. METHODS We conducted a prospective cross-sectional study of CD19-targeted or B cell maturat
Autor:
Ziyi Chang, Guizhen Zhao, Tianqing Zhu, Minerva T. Garcia-Barrio, Yanhong Guo, Huilun Wang, Haocheng Lu, Wenying Liang, Jifeng Zhang, Yanbo Fan, Bo Yang, Oren Rom, Y. Eugene Chen, Jinjian Sun, Yang Zhao, Lin Chang
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
JCI Insight
JCI Insight
Abdominal aortic aneurysm (AAA) is a life-threatening degenerative vascular disease. Endothelial cell (EC) dysfunction is implicated in AAA. Our group recently demonstrated that Kruppel-like factor 11 (KLF11) plays an essential role in maintaining va