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of 9
pro vyhledávání: '"35"'
Autor:
Daniel W. Fitzgerald, Qianjing (Jenny) Xia, Kathleen F. Walsh, Kyu Y. Rhee, Kathrine McAulay, Kathryn M. Dupnik, Warren D. Johnson, Flonza Isa, Jonathan F. Bean, Myung Hee Lee, Jean W. Pape
Publikováno v:
JCI Insight, Vol 5, Iss 18 (2020)
JCI Insight
JCI Insight
BACKGROUND Control of the tuberculosis (TB) pandemic remains hindered in part by a lack of simple and accurate measures of treatment efficacy, as current gold standard markers rely on sputum-based assays that are slow and challenging to implement. Ho
Autor:
Helmut O. Steinberg, Ginger Hook, Robert Monestel, Basel Bayazeed, Jessica Cronin, Alain D. Baron, Manal Tarshoby, Ann Johnson
Publikováno v:
Journal of Clinical Investigation. 100:1230-1239
We have recently shown that insulin-resistant obese subjects exhibit impaired endothelial function. Here, we test the hypothesis that elevation of circulating FFA to levels seen in insulin-resistant subjects can impair endothelial function. We studie
Publikováno v:
Journal of Clinical Investigation. 98:2756-2763
The objective of this study was to evaluate the effect of muscarinic receptor modulation on basal and beta-adrenergic stimulated left ventricular function in patients with heart failure. 21 heart failure patients and 14 subjects with normal ventricul
Publikováno v:
Journal of Clinical Investigation. 66:688-695
The plasma content of B6 vitamers is governed by, among other factors, dietary supply and metabolic interconversion. This study examines the effect of pyridoxine supplementation on the plasma content of B6 vitamers and pyridoxic acid in man, and the
Publikováno v:
Journal of Clinical Investigation. 81:171-175
Genetic deficiency of short-chain acyl-coenzyme A (CoA) dehydrogenase activity was demonstrated in cultured fibroblasts from a 2-yr-old female whose early postnatal life was complicated by poor feeding, emesis, and failure to thrive. She demonstrated
Publikováno v:
Journal of Clinical Investigation. 65:949-957
Abrupt withdrawal after the chronic administration of propranolol has resulted in clinical syndromes that suggest adrenergic hypersensitivity. The effect of propranolol administration and withdrawal on beta-adrenergic receptors was studied in human l
Publikováno v:
Journal of Clinical Investigation. 71:1410-1417
The raised transepithelial electric potential difference (PD) across respiratory epithelia in cystic fibrosis (CF) has suggested an abnormality in ion permeation. We characterized this abnormality further by measuring in the nasal epithelia of CF and
Autor:
Paolo Cavallo-Perin, A. Bruno, Maurizio Cassader, Gianfranco Pagano, A. M. Dall'Omo, P. Masciola, B. Imbimbo, A. Ozzello
Publikováno v:
Journal of Clinical Investigation. 72:1814-1820
Prednisone-induced insulin resistance may depend on either reduced sensitivity (receptor defect) or reduced response to insulin (postreceptor defect). To clarify the mechanism of prednisone-induced insulin resistance, a [3H]glucose infusion (1 microC
Publikováno v:
Journal of Clinical Investigation. 50:1621-1627
The source of plasma dihydrotestosterone (DHT) (17beta-hydroxy-5alpha-androstan-3-one) in humans has been investigated by infusing two potential peripheral precursors, testosterone (T) and androstenedione (A). Metabolic clearance rates (MCR), convers