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Autor:
Sophie Yacoub, Nabil G. Seidah, H C Tan, Duyen Hlt., Huynh Trung Trieu, Bridget Wills, Eng Eong Ooi, Esther S. Gan
Publikováno v:
The Journal of Clinical Investigation
Dengue virus (DENV) infection requires cholesterol as a proviral factor, although statin treatment did not show antiviral efficacy in patients with dengue. Here, we show that DENV infection manipulated cholesterol metabolism in cells residing in low-
Autor:
William L. Holland, Steven C. Hunt, Scott A. Summers, Paul N. Hopkins, James E. Cox, Annelise M Poss, Benedikt J Hauner, J. Alan Maschek, Mary C. Playdon
Publikováno v:
J Clin Invest
BACKGROUND: Ceramides are sphingolipids that play causative roles in diabetes and heart disease, with their serum levels measured clinically as biomarkers of cardiovascular disease (CVD). METHODS: We performed targeted lipidomics on serum samples fro
Autor:
Shelley Barnhart, Noemie Clouet-Foraison, Ira J. Goldberg, Karin E. Bornfeldt, Jenny E. Kanter, Vishal Kothari, Carissa Thornock, Adam E. Mullick, Jay W. Heinecke, Tomas Vaisar, Debapriya Basu, Farah Kramer, Masami Shimizu-Albergine, Robert A. Hegele
Publikováno v:
J Clin Invest
Loss-of-function mutations in the transcription factor CREB3L3 (CREBH) associate with severe hypertriglyceridemia in humans. CREBH is believed to lower plasma triglycerides by augmenting the activity of lipoprotein lipase (LPL). However, by using a m
Autor:
Sanjoy Roychowdhury, Srinivasan Dasarathy, Joan Caballería, Megan R. McMullen, Craig J. McClain, Emily Huang, Gyongyi Szabo, Pau Sancho-Bru, Svetlana Radaeva, Tatsunori Miyata, Xiaoqin Wu, Xiude Fan, Bruce A. Barton, Mack C. Mitchell, Christina K. Cajigas-Du Ross, Annette Bellar, Laura E. Nagy, Jaividhya Dasarathy, Arthur J. McCullough, Daniela S. Allende, Carlos Sanz-Garcia
Publikováno v:
JCI Insight, Vol 6, Iss 4 (2021)
JCI Insight
JCI Insight
Hepatocellular death contributes to progression of alcohol-associated (ALD-associated) and non-alcohol-associated (NAFL/NASH) liver diseases. However, receptor-interaction protein kinase 3 (RIP3), an intermediate in necroptotic cell death, contribute
Autor:
Elias Björnson, Sanni Söderlund, Pietari Ripatti, Antti Hakkarainen, Marcus Ståhlman, Aarno Palotie, Niina Matikainen, Joel T. Rämö, Rosellina Margherita Mancina, Chris J. Packard, Jan Borén, Stefano Romeo, Samuli Ripatti, Martin Adiels, Marja-Riitta Taskinen
Publikováno v:
JCI Insight, Vol 5, Iss 24 (2020)
JCI Insight
JCI Insight
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic lipid accumulation. The transmembrane 6 superfamily member 2 (TM6SF2) E167K genetic variant associates with NAFLD and with reduced plasma triglyceride levels in humans. However, the
Autor:
Hiroyuki Sorimachi, Xiao-Feng Lei, Takuro Miyazaki, Kazuo Tonami, Shoji Hata, Akira Miyazaki, Koji Ohnishi, Joo-ri Kim-Kaneyama, Toshihiro Aiuchi, Hiroki Kurihara, Motohiro Takeya, Hiroyuki Itabe
Publikováno v:
Journal of Clinical Investigation. 126:3417-3432
Macrophages contribute to the development of atherosclerosis through pinocytotic deposition of native LDL–derived cholesterol in macrophages in the vascular wall. Inhibiting macrophage-mediated lipid deposition may have protective effects in athero
Autor:
Chieko Mineo, Philip W. Shaul
Publikováno v:
Journal of Clinical Investigation. 121:2545-2548
Therapies that raise levels of HDL, which is thought to exert atheroprotective effects via effects on endothelium, are being examined for the treatment or prevention of coronary artery disease (CAD). However, the endothelial effects of HDL are highly
Autor:
M. John Chapman, C. Dachet, Yukihiko Ueda, Philippe Lesnik, Veena Afzal, Betty Ouzilleau, C. Doucet, Thierry Huby, Edward M. Rubin
Publikováno v:
Journal of Clinical Investigation. 116:2767-2776
Scavenger receptor SR-BI has been implicated in HDL-dependent atheroprotective mechanisms. We report the generation of an SR-BI conditional knockout mouse model in which SR-BI gene targeting by loxP site insertion produced a hypomorphic allele (hypom
Autor:
Dora M. Kovacs, Avi L. Friedlich, Luigi Puglielli, Carlos Opazo, Kenneth D.R. Setchell, Seiichi Nagano, John D. Wade, Robert A. Cherny, Ashley I. Bush, Simon Melov, Kevin J. Barnham
Publikováno v:
Journal of Clinical Investigation. 115:2556-2563
The abnormal accumulation of amyloid beta-peptide (Abeta) in the form of senile (or amyloid) plaques is one of the main characteristics of Alzheimer disease (AD). Both cholesterol and Cu2+ have been implicated in AD pathogenesis and plaque formation.
Autor:
Susanne Mohr, Andrea Cignarella, Paul Cullen, A. von Eckardstein, B Brennhausen, Gerd Assmann
Publikováno v:
Scopus-Elsevier
In this study, we investigated the impact of the common apoE polymorphism on apoE metabolism and cholesterol homeostasis in monocyte-derived macrophages isolated from E2/2, E3/3, and E4/4 subjects. Unloaded cells of all genotypes contained similar am