Zobrazeno 1 - 10
of 111
pro vyhledávání: ''
Autor:
Damian Justo, Marc G. Caron, Luc Moquin, Ornela Kljakic, Xiang Qi Meng, Pedro Rosa Neto, Erika Vigneault, Philibert Duriez, Helena Janickova, Tharick A. Pascoal, Jun-II Kang, Mark P. Brandon, Jacob P. R. Jacobsen, Marco A. M. Prado, Salah El Mestikawy, Vania F. Prado, Philip Gorwood, Jürgen Germann, Alain Gratton, Léonie Runtz, Mathieu Favier, Sanda Raulic, M. Mallar Chakravarty, Christina Antinora, Daniel Gallino, Joman Y. Natsheh, Mohammad M. Herzallah
Publikováno v:
J Clin Invest
Dysregulation of habit formation has been recently proposed as pivotal to eating disorders. Here, we report that a subset of patients suffering from restrictive anorexia nervosa have enhanced habit formation compared with healthy controls. Habit form
Autor:
Erin R Bonner, Lisa H. Butterfield, Annette M. Molinaro, Nicholas S Whipple, Michael D. Prados, Jared Taitt, Andres M. Salazar, Ryan Gilbert, Sabine Mueller, Javad Nazarian, Neil D. Almeida, Anu Banerjee, Hideho Okada, Susan N. Chi, Karen Gauvain, Javier Villanueva-Meyer, Kellie J. Nazemi, John Robertson Crawford, Rishi Lulla, Payal Watchmaker, Takahide Nejo, Kaori Okada, Stewart Goldman
Publikováno v:
J Clin Invest
The Journal of clinical investigation, vol 130, iss 12
The Journal of clinical investigation, vol 130, iss 12
BACKGROUND: Patients with diffuse midline gliomas (DMGs), including diffuse intrinsic pontine glioma (DIPG), have dismal outcomes. We previously described the H3.3K27M mutation as a shared neoantigen in HLA-A*02.01(+), H3.3K27M(+) DMGs. Within the Pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a8e6a5f77d04da4104612962026915
Autor:
Sabine Mueller, Rodrigo Cartaxo, Viveka Nand Yadav, Rajen Mody, Cassie Kline, Alyssa Paul, Zachary Miklja, Brendan Mullan, Patricia L. Robertson, Ruby Siada, Marcia Leonard, Sriram Venneti, Taylor Garcia, Amy K. Bruzek, Stefanie Stallard, Hugh J. L. Garton, Bernard L. Marini, Carl Koschmann, Chase Thomas, Kyle Wierzbicki, Jann N. Sarkaria, Arul M. Chinnaiyan, Theodore Nicolaides, Daniel R. Wahl, Sarah Leary, Chandan Kumar-Sinha, Chana Glasser, Hemant Parmar, Jessica R. Cummings, Ian Wolfe, Tao Yang, Timothy N. Phoenix, Manjunath P. Pai
Publikováno v:
J Clin Invest
BackgroundPediatric and adult high-grade glioma (HGG) frequently harbor PDGFRA alterations. We hypothesized that co-treatment with everolimus may improve the efficacy of dasatinib in PDGFRα-driven glioma through combinatorial synergism and increased
Autor:
Eva Corey, Paraskevi Giannakakou, Diego A. Gianolio, Jim S. Wu, Carla Calagua, Bruce Montgomery, Ada Gjyrezi, Sandrine Mace, Justin W. Kung, Steven P. Balk, Glenn J. Bubley, Prateek Khanna, Fang Xie, Yang Bai, Olga Voznesensky, Rupal S. Bhatt
Publikováno v:
J Clin Invest
Despite widespread use of taxanes, mechanisms of action and resistance in vivo remain to be established, and there is no way of predicting who will respond to therapy. This study examined prostate cancer (PCa) xenografts and patient samples to identi
Autor:
Amy L. Confides, Esther E. Dupont-Versteegden, Hemendra J. Vekaria, Brian S. Finlin, Philip A. Kern, Patrick G. Sullivan, Hasiyet Memetimin, Jianzhong Chen, Riham H. El Khouli, Philip M. Westgate, Andrew J. Morris, Beibei Zhu, Zachary R. Johnson
Publikováno v:
Journal of Diabetes Investigation
BACKGROUNDBeige adipose tissue is associated with improved glucose homeostasis in mice. Adipose tissue contains β3-adrenergic receptors (β3-ARs), and this study was intended to determine whether the treatment of obese, insulin-resistant humans with
Autor:
Atsushi Kitani, Liming Mao, Kim Montgomery-Recht, Wenchang Zhou, Adrian Wiestner, Ivan J. Fuss, Eitaro Hiejima, Warren Strober
Publikováno v:
J Clin Invest
Bruton tyrosine kinase (BTK) is present in a wide variety of cells and may thus have important non–B cell functions. Here, we explored the function of this kinase in macrophages with studies of its regulation of the NLR family, pyrin domain–conta
Autor:
Grace Tsai, Mandeep S. Singh, Mustafa Iftikhar, Dagmar Wehling, Xiangrong Kong, Lili Lu, G. Michael Wall, Gulnar Hafiz, Anam Akhlaq, Peter A. Campochiaro
Publikováno v:
J Clin Invest
BACKGROUND: In retinitis pigmentosa (RP), rod photoreceptors degenerate from 1 of many mutations, after which cones are compromised by oxidative stress. N-acetylcysteine (NAC) reduces oxidative damage and increases cone function/survival in RP models
Autor:
David P De Souza, Malcolm J. McConville, Andrew D. Cook, Dedreia Tull, Adrian Achuthan, Ming-Chin Lee, Andrew J. Murphy, Sophia Davidson, Andrew J. Fleetwood, John A. Hamilton, Katrina J. Binger, Man K.S. Lee
Publikováno v:
Journal of Clinical Investigation. 129:4239-4244
Macrophage activation in response to LPS is coupled to profound metabolic changes, typified by accumulation of the TCA cycle intermediates citrate, itaconate, and succinate. We have identified that endogenous type I IFN controls the cellular citrate/
Autor:
Erika P. Orner, Carl A. Pierce, Y. Goldstein, Kevan C. Herold, Betsy C. Herold, Marla J. Keller, Benjamin T. Galen, Sharlene Sy
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 9 (2021)
medRxiv
JCI Insight, Vol 6, Iss 9 (2021)
medRxiv
BACKGROUND Coronavirus disease 2019 (COVID-19) is more benign in children compared with adults for unknown reasons. This contrasts with other respiratory viruses where disease manifestations are often more severe in children. We hypothesize that a mo
Autor:
Bjørnar Hassel, Espen Mariussen, Markus Herberg Hovd, Hege Christensen, Aslan Lashkarivand, Are Hugo Pripp, Geir Ringstad, Per Kristian Eide, Hilde Thelle Uggerud
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
JCI Insight
e147063
JCI Insight
e147063
BACKGROUND. Methodology for estimation of cerebrospinal fluid (CSF) tracer clearance could have wide clinical application in predicting excretion of intrathecal drugs and metabolic solutes from brain metabolism and for diagnostic workup of CSF distur