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Publikováno v:
Molecular Biology of the Cell. 34
Cancers are characterized by chromosome instability (CIN), which drives tumor formation, evolution, and drug resistance. In this study, we investigated an intriguing observation that deletion of the evolutionarily conserved helicase Rrm3 leads to a w
Autor:
Kameron L, Inguito, Mandy M, Schofield, Arya D, Faghri, Ellen T, Bloom, Marissa, Heino, Valerie C, West, Karl Matthew M, Ebron, Dawn M, Elliott, Justin, Parreno
Publikováno v:
Molecular Biology of the Cell. 33
Actin is a central mediator between mechanical force and cellular phenotype. In tendons, it is speculated that mechanical stress deprivation regulates gene expression by reducing filamentous (F)-actin. However, the mechanisms regulating tenocyte F-ac
Autor:
Dorothy A. Lerit
Publikováno v:
Molecular Biology of the Cell. 33
It is my great honor to receive the 2022 Günter Blobel Early Career Award from the American Society for Cell Biology. Reflecting upon my research and career trajectory, I recognize the incredible support of my mentors and the hard work of everyone w
Publikováno v:
Molecular Biology of the Cell. 33
The intraflagellar transport (IFT) machinery mediates the import and export of ciliary proteins across the ciliary gate, as well as bidirectional protein trafficking within cilia. In addition to ciliary anterograde protein trafficking, the IFT-B comp
Autor:
Luis Bonet-Ponce, Mark R. Cookson
Publikováno v:
Molecular Biology of the Cell. 33
Lysosomes are dynamic organelles that can remodel their membrane as an adaptive response to various cell signaling events including membrane damage. Recently, we have discovered that damaged lysosomes form and sort tubules into moving vesicles. We na
Autor:
Huaiying Zhang
Publikováno v:
Molecular Biology of the Cell. 33
The RNA-binding protein FUS (FUSed in sarcoma) regulates transcription by binding to polymerases and undergoing phase separation to enrich transcription machinery and RNA processing factors. Using an in vitro transcription assay and a DNA-dependent R
Publikováno v:
Molecular Biology of the Cell
p52SHC (SHC) and GRB2 are adaptor proteins involved in the RAS/MAPK (ERK) pathway mediating signals from cell-surface receptors to various cytoplasmic proteins. To further examine their roles in signal transduction, we studied the translocation of fl
Autor:
Kevin B. Denis, Carl R. Mayer, Katie V Tieu, Jolene I. Cabe, Brooke E. Danielsson, Daniel E. Conway
Publikováno v:
Molecular Biology of the Cell
The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex is a structure consisting of nesprin, SUN, and lamin proteins. A principal function of the LINC complex is anchoring the nucleus to the actin, microtubule, and intermediate filament cytoske
Publikováno v:
Molecular Biology of the Cell
Cancer cells migrating in confined microenvironments exhibit plasticity of migration modes. Confinement of contractile cells in a nonadhesive environment drives “leader bleb–based migration” (LBBM), morphologically characterized by a long bleb
Autor:
Daniel A. Hammer, Sarah Hyun Ji Kim
Publikováno v:
Molecular Biology of the Cell
To carry out their physiological responsibilities, CD4+ T lymphocytes interact with various tissues of different mechanical properties. Recent studies suggest that T cells migrate upstream on surfaces expressing intracellular adhesion molecule-1 (ICA