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Publikováno v:
Molecular Biology of the Cell
Metaphase spindles exert pole-directed forces on still-connected sister kinetochores. The spindle must counter these forces with extensive forces to prevent spindle collapse. In small spindles, kinetochore microtubules (KMTs) connect directly with th
Autor:
Daniel L. Kilpatrick, John W. Cave, Chi-Wing Chow, Baojin Ding, Wei Wang, Paul R. Dobner, Debra Mullikin-Kilpatrick, Hong Zhu, Richard M. Gronostajski
Publikováno v:
Molecular Biology of the Cell
We show that BDNF regulates the timing of neurodevelopment via a novel mechanism of extranuclear sequestration of NFATc4 in Golgi. This leads to accelerated derepression of an NFI temporal occupancy gene program in cerebellar granule cells that inclu
Autor:
Michael J. Emanuele, Ashlyn M. Spring, Ying Wen, Sara ten Have, Kelsey M. Gray, Gregory D. Van Duyne, Thomas Bonacci, Kushol Gupta, Christian L. Lorson, Kevin A. Kaifer, Amanda C. Raimer, Allison D. Ebert, Eric J. Wagner, A. Gregory Matera, Jacqueline J. Glascock, David Baillat, Angus I. Lamond
Publikováno v:
Molecular Biology of the Cell
SMN protein levels inversely correlate with the severity of spinal muscular atrophy. The SCFSlmbE3 ligase complex interacts with a degron embedded within the C-terminal self-oligomerization domain of SMN. The findings elucidate a model whereby access
Publikováno v:
Molecular Biology of the Cell
Although anti-inflammatory macrophages perform macropinocytosis constitutively, proinflammatory macrophages do not, due to impaired signaling of the calcium-sensing receptor. However, macropinocytosis can be elicited in proinflammatory macrophages by
Autor:
Youtao Liu, Ivan R. Nabi, Bharat H. Joshi, Fanrui Meng, Sandeep Saxena, Leonard J. Foster, Pascal Bernatchez, Jay Shankar, Timothy H. Wong
Publikováno v:
Molecular Biology of the Cell
The caveolin scaffolding domain mediates the promigratory activity of Src-phosphorylated (on Y14) caveolin-1 and, specifically, regulation of vinculin tension in focal adhesions. This suggests that pY14Cav1 enhances cancer cell migration by promoting
Autor:
Ali Reza Nazmi, Volker Gerke, Henriette Koch, Nils Brose, Anna Holthenrich, Sonja M. Wojcik, Thomas Martin, Nina Criado Santos, Kwun Nok Mimi Man, Peter van der Sluijs, Jennifer Disse, Christian Schuberth, Maaike Neeft, Tarek Chehab, Sophia N. Koerdt
Publikováno v:
Molecular Biology of the Cell
The tethering factor Munc13-4 is recruited to Weibel–Palade body (WPB) fusion sites after secretagogue stimulation to promote WPB exocytosis. Annexin A2-S100A10 is a novel Munc13-4 interaction partner assisting Munc13-4 tethering at the plasma memb
Publikováno v:
Molecular Biology of the Cell
This study examines the mechanism of glycocalyx injury under low shear stress (LSS). LSS-induced changes of eNOS phosphorylation and NO production are based on the deficiency of the glycocalyx barrier.
Hyaluronan (HA) in the endothelial glycocal
Hyaluronan (HA) in the endothelial glycocal
Publikováno v:
Molecular Biology of the Cell
PKC phosphorylation promotes its sumoylation, which in turn inhibits its ubiquitination and ultimately reduces its degradation via the ubiquitin-proteasome pathway. These findings provide a molecular explanation for the activation-induced down-regula
Autor:
Gu Zhu, Guanghu Wang, Jacek Bielawski, Michael B. Dinkins, Qian He, Stefka D. Spassieva, Kara Hardin, Ji Na Kong, Erhard Bieberich, Tarik Mujadzic
Publikováno v:
Molecular Biology of the Cell
Cilia are important organelles formed by cell membrane protrusions; however, little is known about their regulation by membrane lipids. A novel, evolutionarily conserved activation mechanism for GSK3 by the sphingolipid (phyto)ceramide is characteriz
Autor:
Anne E. Goldman, Yixian Zheng, Stephen A. Adam, Khuloud Jaqaman, Joseph R. Tran, Robert D. Goldman, Mark Kittisopikul, Takeshi Shimi
Publikováno v:
Molecular Biology of the Cell
Superresolution microscopy and computational image analysis demonstrate that the four nuclear lamin isoforms of mammalian cells are each organized into distinct meshwork structures sharing similar physical characteristics. Knockouts of single lamins