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Publikováno v:
Molecular Biology of the Cell
Cancer cells migrating in confined microenvironments exhibit plasticity of migration modes. Confinement of contractile cells in a nonadhesive environment drives “leader bleb–based migration” (LBBM), morphologically characterized by a long bleb
Autor:
Bryan A Leland, Amber F. Buhagiar, Lisa M. Ogawa, Susan J. Baserga, Yulia V. Surovtseva, Laura Abriola
Publikováno v:
Molecular Biology of the Cell
Nucleoli are dynamic nuclear condensates in eukaryotic cells that originate through ribosome biogenesis at loci that harbor the ribosomal DNA. These loci are known as nucleolar organizer regions (NORs), and there are 10 in a human diploid genome. Whi
Publikováno v:
Molecular Biology of the Cell
Similar to other core biological processes, the vast majority of cell division components are essential for viability across human cell lines. However, genome-wide screens have identified a number of proteins that exhibit cell line-specific essential
Autor:
Brodie Buchner-Duby, Jing X. Kang, Scott D. Ryan, David W.L. Ma, Jennifer Drolet, Morgan G. Stykel, Carla Coackley
Publikováno v:
Molecular Biology of the Cell
Evidence suggests that n-3 polyunsaturated fatty acids may act as activators of the Nrf2 antioxidant pathway. The antioxidant response, in turn, promotes neuronal differentiation and neurite outgrowth. Nrf2 has recently been suggested to be a cell in
Autor:
Ariadna Giro-Perafita, Marion Failler, Brian David Dynlacht, Mikito Owa, David J. Kahler, Irma Sánchez, Derya Unutmaz, Francisco J. Esteva, Shalini Srivastava, Chi Yun
Publikováno v:
Molecular Biology of the Cell. 32:169-185
We performed a high-throughput whole-genome RNAi screen to identify novel inhibitors of ciliogenesis in normal and basal breast cancer cells. Our screen uncovered a previously undisclosed, extensive network of genes linking integrin signaling and cel
Autor:
Oliver M. Sieber, Christopher G. Love, Maree C. Faux, Antony W. Burgess, Lauren E. King, Serena R Kane
Publikováno v:
Molecular Biology of the Cell. 32:120-130
The adenomatous polyposis coli (APC) tumor suppressor protein is associated with the regulation of Wnt signaling; however, APC also controls other cellular processes including the regulation of cell adhesion and migration. The expression of full-leng
Publikováno v:
Molecular Biology of the Cell
The epithelial cell-specific clathrin adaptor protein (AP)-1B has a well-established role in polarized sorting of cargos to the basolateral membrane. Here we show that β1 integrin was dependent on AP-1B and its coadaptor, autosomal recessive hyperch
Publikováno v:
Molecular Biology of the Cell
Nuclear envelope proteins influence cell cytoarchitecure by poorly understood mechanisms. Here we show that small interfering RNA-mediated silencing of lamin A/C (LMNA) promotes contrasting stress fiber assembly and disassembly in individual cells an
Autor:
Anthony Bretscher, Matthew R Miller, Riasat Zaman, Andrew J Lombardo, David J. McDermitt, Cécile Sauvanet
Publikováno v:
Molecular Biology of the Cell. 33
Here we report on the related TBC/RabGAPs EPI64A and EPI64B and show that they function to organize the apical aspect of epithelial cells. EPI64A binds the scaffolding protein EBP50/NHERF1, which itself binds active ezrin in epithelial cell microvill
Resveratrol and related stilbene derivatives induce stress granules with distinct clearance kinetics
Autor:
Daniel Kaganovich, Anthony Guihur, Christina Zelent, Jörg Wilting, Robertas Ursache, Triana Amen
Publikováno v:
Molecular biology of the cell, vol. 32, no. 21, pp. ar18
Molecular Biology of the Cell
Molecular Biology of the Cell
Stress granules (SGs) are ribonucleoprotein functional condensates that form under stress conditions in all eukaryotic cells. Although their stress-survival function is far from clear, SGs have been implicated in the regulation of many vital cellular