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pro vyhledávání: '"Martin Egli"'
Classical DNA and RNA polymerase (pol) enzymes have defined roles with their respective substrates, but several pols have been found to have multiple functions. We reported previously that purified human DNA pol η (hpol η) can incorporate both deox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e38d0c2332636820ab6aa6b43095cc7
https://europepmc.org/articles/PMC6463694/
https://europepmc.org/articles/PMC6463694/
Autor:
Zdzislaw Wawrzak, Martin Egli, Eric Gonzalez, Pradeep S. Pallan, Wei Zhang, Thanh T.N. Phan, F. Peter Guengerich, Kevin M. Johnson, Li Lei, Francis K. Yoshimoto
Cytochrome P450 (P450) 17A1 catalyzes the oxidations of progesterone and pregnenolone and is the major source of androgens. The enzyme catalyzes both 17α-hydroxylation and a subsequent 17α,20-lyase reaction, and several mechanisms have been propose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d35f5a8c8206ba80667e32e85dce208
https://europepmc.org/articles/PMC5767860/
https://europepmc.org/articles/PMC5767860/
O6-Methyl-2′-deoxyguanosine (O6-MeG) is a ubiquitous DNA lesion, formed not only by xenobiotic carcinogens but also by the endogenous methylating agent S-adenosylmethionine. It can introduce mutations during DNA replication, with different DNA poly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a5018873c2aeb8a5dff6b87e3ec8db
https://europepmc.org/articles/PMC5104950/
https://europepmc.org/articles/PMC5104950/
Like the other Y-family DNA polymerases, human DNA polymerase η (hpol η) has relatively low fidelity and is able to tolerate damage during DNA synthesis, including 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxoG), one of the most abundant DNA lesions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe21ee869113cefff30a6035f0aabfd
https://europepmc.org/articles/PMC4481197/
https://europepmc.org/articles/PMC4481197/