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Autor:
Jan R. Kraehling, Joseph W. Fowler, Warren L. Lee, Carlos Fernández-Hernando, Siavash Ghaffari, William C. Sessa, Sungwoon Lee, Christina M. Ramirez, Bo Tao, Anne Eichmann
Publikováno v:
The Journal of Biological Chemistry
Bone morphogenetic protein-9 (BMP-9) is a circulating cytokine that is known to play an essential role in the endothelial homeostasis and the binding of BMP-9 to the receptor activin-like kinase 1 (ALK-1) promotes endothelial cell quiescence. Previou
Autor:
Mauro Montalbano, Filippa Lo Cascio, Rakez Kayed, Salome McAllen, Nicha Puangmalai, Antonio Palumbo Piccionello, Stephanie Garcia, Andrea Pace
Publikováno v:
The Journal of Biological Chemistry
The pathological aggregation of tau plays an important role in Alzheimer's disease and many other related neurodegenerative diseases, collectively referred to as tauopathies. Recent evidence has demonstrated that tau oligomers, small and soluble pref
Autor:
Davide Vigetti, Daiana Lujan Vitale, Giancarlo De Luca, Paola Moretto, Laura Alaniz, Elena Caravà, Vincent C. Hascall, Manuela Viola, Evgenia Karousou, Arianna Parnigoni, Alberto Passi, Barbara Bartolini, Ilaria Caon
Publikováno v:
The Journal of Biological Chemistry
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Hyaluronan (HA) is one of the most prevalent glycosaminoglycans of the vascular extracellular matrix (ECM). Abnormal HA accumulation within blood vessel walls is associated with tissue inflammation and is prominent in most vascular pathological condi
Autor:
Karl J. Wahlin, Jun Wan, Ravi Chakra Turaga, Cynthia A. Berlinicke, Jiang Qian, Joseph L. Mertz, Melissa M. Liu, Ming-Wen Hu, Donald J. Zack, Srinivasa R. Sripathi, Julien Maruotti
Publikováno v:
Molecular & Cellular Proteomics : MCP
Stress and injury to the retinal pigment epithelium (RPE) often lead to dedifferentiation and epithelial-to-mesenchymal transition (EMT). These processes have been implicated in several retinal diseases, including proliferative vitreoretinopathy, dia
Autor:
Hiroyuki Sugimoto, Yasuhiro Horibata
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100100-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100100-(2021)
Choline phospholipids (PLs) such as phosphatidylcholine (PC) and 1-alkyl-2-acyl-sn-glycerophosphocholine are important components for cell membranes and also serve as a source of several lipid mediators. These lipids are biosynthesized in mammals in
Autor:
Xiaoyong Yang, Kalina Lapenta, Dongjun Chung, Michael H. Nathanson, Marie E. Robert, Jin Hyun Nam, Bichen Zhang, Qi Wang
Publikováno v:
The Journal of Biological Chemistry
Liver fibrosis is a common characteristic of chronic liver diseases. The activation of hepatic stellate cells (HSCs) plays a key role in fibrogenesis in response to liver injury, yet the mechanism by which damaged hepatocytes modulate the activation
Autor:
Apple Cortez Vollmers, Christopher Vollmers, Sophia Campos, Susan Carpenter, Honey E. Mekonen
Publikováno v:
The Journal of Biological Chemistry
RNA-seq is routinely used to measure gene expression changes in response to cell perturbation. Genes upregulated or downregulated following some perturbation are designated as genes of interest, and their most expressed isoform(s) would then be selec
Publikováno v:
The Journal of Biological Chemistry
The retention of low-density lipoprotein (LDL) is a key process in the pathogenesis of atherosclerosis and largely mediated via smooth-muscle cell-derived extracellular proteoglycans including the glycosaminoglycan chains. Macrophages can also intern
Autor:
Zongming Song, Xiexie Liu, Ji-Neng Lv, Xiaoyu Liu, Junzhao Zhao, Haihua Xie, Chenchen Zhou, Yuanyuan Liu, Bang Wang, Xiubin He, Yong Liu, Xiujuan Lv, Mingchun Li, Feng Gu, Lianchao Tang, Changbao Liu
Publikováno v:
The Journal of Biological Chemistry
Clustered regularly interspaced short palindromic repeat–Cas12a has been harnessed to manipulate the human genome; however, low cleavage efficiency and stringent protospacer adjacent motif hinder the use of Cas12a-based therapy and applications. He
Autor:
Lucia G. Sivilotti, Hongtao Zhu, Jie Yu, Vid Jazbec, Remigijus Lape, Josip Ivica, Matthew G. Gold, Eric Gouaux
Publikováno v:
The Journal of Biological Chemistry
Like other pentameric ligand-gated channels, glycine receptors (GlyRs) contain long intracellular domains (ICDs) between transmembrane helices 3 and 4. Structurally characterized GlyRs are generally engineered to have a very short ICD. We show here t