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The inflammasome contains intracellular receptors that recognize various pathogen-associated molecular patterns and play crucial roles in innate immune responses to invading pathogens. Non-canonical inflammasome activation is mediated by caspase-4/11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c88bfb0bfca338933cd716dd3143d034
https://europepmc.org/articles/PMC5733597/
https://europepmc.org/articles/PMC5733597/
Autor:
Radu G. Avramescu, Connie M. Krawczyk, Benedeta Hasaj, Manuella Bouttier, Vassil Dimitrov, Gergely L. Lukacs, Babak Memari, John H. White, Reyhaneh Salehi-Tabar, Giselle M. Boukhaled
PD-L1 (programmed death ligand 1) and PD-L2 are cell-surface glycoproteins that interact with programmed death 1 (PD-1) on T cells to attenuate inflammation. PD-1 signaling has attracted intense interest for its role in a pathophysiological context:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f684540838188abb1aaa25191a6be7
https://europepmc.org/articles/PMC5733602/
https://europepmc.org/articles/PMC5733602/
Autor:
Travis Clarke Beddoe, Matthew J. Wenhwa Sum, Gabriella Pietra, Lorenzo Moretta, Lucy C. Sullivan, Eleanor J Lee, Craig S Clements, C. Farenc, Jamie Rossjohn, Nicholas G Walpole, Michela Falco, Andrew G. Brooks, Maria Cristina Mingari, Stephanie Gras
αβ T cell receptors (TCRs) interact with peptides bound to the polymorphic major histocompatibility complex class Ia (MHC-Ia) and class II (MHC-II) molecules as well as the essentially monomorphic MHC class Ib (MHC-Ib) molecules. Although there is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de2b1644d5e414ef7647fb2adf5af3e
https://europepmc.org/articles/PMC5743087/
https://europepmc.org/articles/PMC5743087/
Protein arginine methyltransferase 1 (PRMT1) is an essential enzyme controlling about 85% of the total cellular arginine methylation in proteins. We have shown previously that PRMT1 is an important regulator of innate immune responses and that it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da309942918c324ad04096b60d634317
https://europepmc.org/articles/PMC5555193/
https://europepmc.org/articles/PMC5555193/
Autor:
Pranal J. Dakle, F. Anthony Romero, Alexander B. Taylor, Charlie Hatton, Venita G. Watson, Hari Jayaram, Srimoyee Ghosh, Andres Salmeron, Peter Sandy, Steve Bellon, Deanna A. Mele, Jennifer A. Mertz, Thornik Reimer, Hon-Ren Huang, Jose M. Lora, Georgia Hatzivassiliou, Laura Zawadzke, Richard T. Cummings, Robert J. Sims, Jeremy W. Setser, Eneida Pardo, Alexandre Côté, Steven Magnuson, Barbara M. Bryant, James E. Audia, Eugene Chiang, Andrew R. Conery, Florence Poy, Andrea G. Cochran, Melissa Chin, Jean-Christophe Harmange, Vickie Tsui, Brian K. Albrecht, Terry Crawford, Denise DeAlmeida-Nagata, Jane L. Grogan
Covalent modification of histones is a fundamental mechanism of regulated gene expression in eukaryotes, and interpretation of histone modifications is an essential feature of epigenetic control. Bromodomains are specialized binding modules that inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a712c5d807a46e4b8f4f88a0d24e73
https://europepmc.org/articles/PMC4933219/
https://europepmc.org/articles/PMC4933219/
Autor:
Emi Sato, Christopher A. Adase, Ling-juan Zhang, Richard L. Gallo, Michael R. Williams, James A. Sanford, Andrew W. Borkowski
Publikováno v:
The Journal of biological chemistry, vol 291, iss 22
A critical function for skin is that when damaged it must simultaneously identify the nature of the injury, repair barrier function, and limit the intrusion of pathogenic organisms. These needs are carried out through the detection of damage-associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d83a62694e5aa7142eb171a6a43fce
https://europepmc.org/articles/PMC4882433/
https://europepmc.org/articles/PMC4882433/
Autor:
Ten Feizi, Janet A. Willment, Matti Kimberg, Gordon D. Brown, María Asunción Campanero-Rhodes, Peter Sobieszczuk, Angelina S. Palma, Vandana Gupta, William G. Hornsell, Stella K. Kim, Kevin M. Dennehy, Lisa M. Graham, Reto Guler, Georgia Schäfer, Delyth M. Reid
Publikováno v:
The Journal of Biological Chemistry
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
11 pags, 7 figs
CLECSF8 is a poorly characterized member of the "Dectin-2 cluster" of C-type lectin receptors and was originally thought to be expressed exclusively by macrophages. We show here that CLECSF8 is primarily expressed by peripheral b
CLECSF8 is a poorly characterized member of the "Dectin-2 cluster" of C-type lectin receptors and was originally thought to be expressed exclusively by macrophages. We show here that CLECSF8 is primarily expressed by peripheral b
Autor:
Christopher B. Howard, Tom P. Monie, Joseph A. Duncan, Beckley K. Davis, Joseph P. Boyle, Jinyao Mo
Publikováno v:
The Journal of Biological Chemistry
Background: Nucleotide binding and oligomerization domain-containing protein 2 (NOD2) is a protein involved in the recognition of bacterial pathogens through detection of muramyl dipeptide. Results: Purified recombinant NOD2 was found to bind ATP and
Autor:
Susanne Wiederkum, Florian Rüker, Manuela Kainer, Herta Steinkellner, Max Woisetschläger, Josephine Grass, Alexandra Castilho, Jakub Jez, Bernhard Antes
Publikováno v:
The Journal of Biological Chemistry
Background: Fcabs are small antibody-like molecules that medicate effector functions. Results: Single N-glycan residues on Fcabs significantly contribute to therapeutically relevant effector functions. Conclusion: Therapeutic proteins with optimized
Autor:
Zoe Briggs, Louisa E. Jeffery, Satdip Kaur, Natalie S. Poulter, Omar S. Qureshi, Anna K. Willox, David M. Sansom, Tie Zheng Hou, Stephen J. Royle, Rupert Kenefeck, Joshua Z. Rappoport
Publikováno v:
The Journal of Biological Chemistry
Background: CTLA-4 is an essential regulator of T cell immune responses with unusual intracellular trafficking. Results: Endocytosis of CTLA-4 is continuous with subsequent recycling and degradation. Conclusion: Clathrin-mediated endocytosis of CTLA-