Zobrazeno 1 - 10
of 95
pro vyhledávání: ''
Autor:
Yashar S. Niknafs, Monica Palande, Karthik R. Padmanabhan, Matthew K. Iyer, Gilbert S. Omenn, Tingting Qin, Anjan K. Saha, Tara Tang, Maureen A. Sartor, Brian Qian, Scott D. Gitlin, David M. Markovitz, Elizabeth A. Ward, Rafael Contreras-Galindo, Arul M. Chinnaiyan, Javed Siddiqui, Claire L. Wang, Scott A. Tomlins
Publikováno v:
The Journal of Biological Chemistry
Overexpression of centromeric proteins has been identified in a number of human malignancies, but the functional and mechanistic contributions of these proteins to disease progression have not been characterized. The centromeric histone H3 variant ce
Autor:
Xinghua Zhen, Suxia Han, Lichun Tang, Yiping Dong, Lingzhi Wu, Jin Peng, Jiewei Wang, Huailu Ma, Pumin Zhang, Jianping Jin
Publikováno v:
The Journal of Biological Chemistry
Triple-negative breast cancer lacks significant expression of the estrogen receptor, the progesterone receptor, and of human epidermal growth factor receptor. It is the most aggressive and malignant of all breast cancers, and for which there are curr
Autor:
Zhenyu Luo, Cuifu Yu, Renjie Chai, Hongbiao Huang, Yangshuo Jin, Ningning Liu, Xiaohong Xia, Tumei Hu, Bijun Du, Jielei Gu, Qiong Xu, Shiming Liu, Wenchao Ou, Xiaolin Liu
Publikováno v:
The Journal of Biological Chemistry
The underlying mechanism of neointima formation remains unclear. Ubiquitin-specific peptidase 10 (USP10) is a deubiquitinase that plays a major role in cancer development and progression. However, the function of USP10 in arterial restenosis is unkno
Publikováno v:
The Journal of Biological Chemistry
Metabolic flexibility is the capacity of cells to alter fuel metabolism in response to changes in metabolic demand or nutrient availability. It is critical for maintaining cellular bioenergetics and is involved in the pathogenesis of cardiovascular d
Autor:
Yuanming He, Zubin Zhang, Yuanying Zeng, Xinliang Mao, Jun Zhao, Chenyu Mao, Hui Zheng, Shuoyi Jiang, Biyin Cao
Publikováno v:
The Journal of Biological Chemistry
The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein is a key player in tumorigenesis of non–small cell lung cancer (NSCLC) and was recently found to be inactivated by tripartite motif containing 25 (TRIM25)–mediated K63-lin
Publikováno v:
The Journal of Biological Chemistry
The Hippo pathway is an evolutionarily conserved signaling pathway that controls organ size in animals via the regulation of cell proliferation and apoptosis. It consists of a kinase cascade, in which MST1/2 and MAP4Ks phosphorylate and activate LATS
Autor:
Franziska Gehringer, Peter E. Shaw, Charles Ducker, Janice Saxton, Reyna Sara Quintero-Barceinas
Publikováno v:
The Journal of Biological Chemistry
The mitogen-responsive, ETS-domain transcription factor ELK-1 stimulates the expression of immediate early genes at the onset of the cell cycle and participates in early developmental programming. ELK-1 is subject to multiple levels of posttranslatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a50c4ba158f8970d57e3747454dc16
https://nottingham-repository.worktribe.com/file/5291909/1/1-s2.0-S0021925820002100-main
https://nottingham-repository.worktribe.com/file/5291909/1/1-s2.0-S0021925820002100-main
Publikováno v:
The Journal of Biological Chemistry
Rho/Ras family small GTPases are known to regulate numerous cellular processes, including cytoskeletal reorganization, cell proliferation, and cell differentiation. These processes are also controlled by Ca2+, and consequently, cross talk between the
Autor:
Roberta L. Beauchamp, Vijaya Ramesh, Justin T. Jordan, Serkan Erdin, Scott R. Plotkin, James F. Gusella, Luke Witt
Publikováno v:
The Journal of Biological Chemistry
Meningiomas (MNs), arising from the arachnoid/meningeal layer, are nonresponsive to chemotherapies, with ∼50% showing loss of the Neurofibromatosis 2 (NF2) tumor suppressor gene. Previously, we established NF2 loss activates mechanistic target of r
Autor:
Mingcheng Liu, Jun A, Baotong Zhang, Zhiqian Zhang, Rui Wu, Juan Li, Liya Fu, Gui Ma, Jin-Tang Dong, Jiali Fang, Wenxuan Chen, Jinming Liu
Publikováno v:
J Biol Chem
SUMOylation is a posttranslational modification (PTM) at a lysine residue and is crucial for the proper functions of many proteins, particularly of transcription factors, in various biological processes. Zinc finger homeobox 3 (ZFHX3), also known as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d21fbe3491f31708d0782442307f69
https://europepmc.org/articles/PMC7212658/
https://europepmc.org/articles/PMC7212658/