Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Colin, P."'
Autor:
Eric B. Thorstensen, Philip N. Baker, Susan L. Greenwood, Colin P. Sibley, Mark Wareing, Lewis Renshall, Elizabeth Cottrell, Mark Dilworth, Elizabeth Cowley
Publikováno v:
Renshall, L, Cottrell, E, Cowley, E, Sibley, C, Baker, P N, Thortensen, E B, Greenwood, S, Wareing, M & Dilworth, M 2020, ' Antenatal sildenafil citrate treatment increases offspring blood pressure in the placental-specific Igf2 knockout mouse model of FGR ', American Journal of Physiology: Heart and Circulatory Physiology, vol. 318, no. 2, pp. H252-H263 . https://doi.org/10.1152/ajpheart.00568.2019
Fetal growth restriction (FGR), where a fetus fails to reach its genetic growth potential, affects up to 8% of pregnancies and is a major risk factor for stillbirth and adulthood morbidity. There are currently no treatments for FGR, but candidate the
Autor:
Bram G. Sengers, N Panitchob, Jocelyn D. Glazier, Colin P. Sibley, Edward D. Johnstone, Ian P. Crocker, Susanne Brooks, Kate Widdows, Rohan M. Lewis, Simone Perazzolo, Emma M. Lofthouse
Publikováno v:
Lofthouse, E M, Perazzolo, S, Brooks, S, Crocker, I P, Glazier, J D, Johnstone, E D, Panitchob, N, Sibley, C P, Widdows, K L, Sengers, B G & Lewis, R M 2016, ' Phenylalanine transfer across the isolated perfused human placenta : an experimental and modeling investigation ', American journal of physiology. Regulatory, integrative and comparative physiology, vol. 310, no. 9, pp. R828-R836 . https://doi.org/10.1152/ajpregu.00405.2015
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Membrane transporters are considered essential for placental amino acid transfer, but the contribution of other factors, such as blood flow and metabolism, is poorly defined. In this study we combine experimental and modeling approaches to understand
Autor:
Colin P. Sibley, John D. Aplin, Mark Dilworth, Melissa Westwood, Ian P. Crocker, Jayne Charnock
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism
Charnock, J, Dilworth, M, Aplin, J, Sibley, C, Westwood, M & Crocker, I P 2016, ' The impact of a human IGF-II analog ([Leu27]IGF-II) on fetal growth in a mouse model of fetal growth restriction ', American journal of physiology. Endocrinology and metabolism, vol. 310, no. 1, pp. E24-E31 . https://doi.org/10.1152/ajpendo.00379.2015
Charnock, J, Dilworth, M, Aplin, J, Sibley, C, Westwood, M & Crocker, I P 2016, ' The impact of a human IGF-II analog ([Leu27]IGF-II) on fetal growth in a mouse model of fetal growth restriction ', American journal of physiology. Endocrinology and metabolism, vol. 310, no. 1, pp. E24-E31 . https://doi.org/10.1152/ajpendo.00379.2015
Enhancing placental insulin-like growth factor (IGF) availability appears to be an attractive strategy for improving outcomes in fetal growth restriction (FGR). Our approach was the novel use of [Leu27]IGF-II, a human IGF-II analog that binds the IGF
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Fetal growth restriction (FGR) affects 3–8% of human pregnancies. Mouse models have provided important etiological data on FGR; they permit the assessment of treatment strategies on the physiological function of both mother and her developing offsp
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 313:L964-L965
to the editor: In a recent issue of the American Journal of Physiology-Lung Cellular and Molecular Physiology , we read with great interest the review article by Chun et al. ([2][1]) about potential pulmonary effects of electronic cigarettes (ECs). T
Autor:
Cassandra J. Hirt, Mark Wareing, Mark Dilworth, Bernadette Baker, Colin P. Sibley, Irene J. Andersson, Jocelyn D. Glazier, Joanna L. Stanley, Lewis Renshall, Philip N. Baker, L.C. Kusinski
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 303:R86-R93
Fetal growth restriction (FGR) is the inability of a fetus to reach its genetically predetermined growth potential. In the absence of a genetic anomaly or maternal undernutrition, FGR is attributable to “placental insufficiency”: inappropriate ma
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 295:R1204-R1213
Maintaining placental syncytiotrophoblast, a specialized multinucleated transport epithelium, is essential for normal human pregnancy. Syncytiotrophoblast continuously renews through differentiation and fusion of cytotrophoblast cells, under paracrin
Autor:
Carolyn J.P. Jones, John M. Rawlings, Susan L. Greenwood, Sarah J. Mann, E. E. Champion, Colin P. Sibley, Jocelyn D. Glazier
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 287:R1369-R1379
There is no knowledge of the transport mechanisms by which solutes cross the cat placenta or any other endotheliochorial placenta. Here, we investigated whether the amino acid transport systems β and A are present in the cat placenta using a placent
Publikováno v:
Europe PubMed Central
We have investigated the functional characteristics of term human placental villous explants kept in long-term (7–11 days) culture. Fragments of placental villous tissue (∼5–10 mg wet wt) were cultured in supplemented CMRL-1066 culture medium f
Gestational changes in Ca2+ transport across rat placenta and mRNA for calbindin9K and Ca(2+)-ATPase
Autor:
Kent Thornburg, R.D.H. Boyd, Jocelyn D. Glazier, D.E. Atkinson, Colin P. Sibley, Paul T. Sharpe, D. Edwards
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 263:R930-R935
The unidirectional maternofetal clearance (Kmf) of 45Ca was measured across the rat placenta over the last one-third of gestation. Kmf for 45Ca normalized to its diffusion coefficient in water (Kmf/Dw) increased 72-fold between days 15 and 22 of gest