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Publikováno v:
American Journal of Physiology-Renal Physiology. 320:F963-F971
Psychotropic drugs may be associated with hyponatremia, but an understanding of how they induce water retention in the kidney remains elusive. Previous studies have postulated that they may increase vasopressin production in the hypothalamus without
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Severe trauma can produce a postinjury “metabolic self-destruction” characterized by catabolic metabolism and hyperglycemia. The severity of the hyperglycemia is highly correlated with posttrauma morbidity and mortality. Although no mechanism has
Autor:
Grace O. Ciabattoni, Linda J. Lowe-Krentz, Kayli A. Silimperi, Leanna M. Talotta-Altenburg, Yaqiu Li
Publikováno v:
Am J Physiol Cell Physiol
Published studies indicate that TMEM184A is a heparin receptor that interacts with and transduces stimulation from heparin in vascular cells. Previous studies have indicated that heparin increases endothelial nitric oxide synthase (eNOS) activity in
Publikováno v:
American Journal of Physiology-Renal Physiology. 318:F683-F688
Exaggerated activation of the renin-angiotensin-aldosterone system (RAAS) is a key feature in diseases such as hypertension, diabetes, and chronic kidney disease. Recently, an intracellular RAAS was demonstrated with angiotensin II (ANG II) type 1 (A
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
Compounds described by humans as “bitter” are sensed by a family of type 2 taste receptors (T2Rs). Previous work suggested that diverse bitter stimuli activate distinct receptors, which might allow for perceptually distinct tastes. Alternatively,
Autor:
Meichan Li, Jun Zhang, Qian Jiang, Dejun Sun, Lei Xu, Yuqin Chen, Haiyang Tang, Ziyi Wang, Wenju Lu, Jian Wang, Kai Yang, Xin Duan
Publikováno v:
American Journal of Physiology-Cell Physiology. 311:C482-C497
The ubiquitin-proteasome system is considered to be the key regulator of protein degradation. Bortezomib (BTZ) is the first proteasome inhibitor approved by the US Food and Drug Administration for treatment of relapsed multiple myeloma and mantle cel
Autor:
Yao Liang Tang, Jian Peng Teoh, Neal L. Weintraub, Kyoung-mi Park, Ahmed S. Bayoumi, Il-man Kim, Zuzana Broskova, Yongchao Wang, Huabo Su
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 311:H371-H383
The nonselective β-adrenergic receptor antagonist (β-blocker) carvedilol has been shown to protect against myocardial injury, but the detailed underlying mechanisms are unclear. We recently reported that carvedilol stimulates the processing of micr
Formoterol decreases muscle wasting as well as inflammation in the rat model of rheumatoid arthritis
Autor:
Ana Isabel Martín, Carmen Fernández-Galaz, Ana Belén Gómez-SanMiguel, Asunción López-Calderón, María Ángeles Villanúa, Carolina Gomez-Moreira, María Paz Nieto-Bona
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 310:E925-E937
Adjuvant-induced arthritis is an experimental model of rheumatoid arthritis that is associated with body weight loss and muscle wasting. β2-adrenergic receptor agonists are powerful anabolic agents that trigger skeletal muscle hypertrophy and have b
Patients with peripheral artery disease show an exaggerated pressor response to mild exercise, an effect attributable to the exercise pressor reflex, whose afferent arm comprises the thinly myelinated group III and unmyelinated group IV afferents. Pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc68d02a1a580d19dcfa069e2f0a02d
https://europepmc.org/articles/PMC6032119/
https://europepmc.org/articles/PMC6032119/
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 309:H185-H197
Adenosine is a powerful central neuromodulator acting via opposing A1 (inhibitor) and A2a (activator) receptors. However, in the nucleus of the solitary tract (NTS), both adenosine receptor subtypes attenuate cardiopulmonary chemoreflex (CCR) sympath