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Publikováno v:
Journal of Neurophysiology. 100:1147-1151
The effect of N-arachidonoyl l-serine (ARA-S), a recently discovered lipoamino acid found in the CNS, on N-type Ca2+ channels of rat sympathetic ganglion neurons was determined using whole cell patch clamp. Application of ARA-S produced a rapid and r
Autor:
Allison E. Sahr, Michael A. Statnick, Charles H. Mitch, Dana Sindelar, Jesline T. Alexander-Chacko, Brian J. Eastwood
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 295:R463-R471
An analog of the trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine series (LY255582) exhibits high in vitro binding affinity and antagonist potency for the μ-, δ-, and κ-opioid receptors. In vivo, LY255582 exhibits potent effects in reducing food i
Publikováno v:
American Journal of Physiology-Renal Physiology. 295:F37-F41
Adenosine mediates Na+reabsorption in the proximal tubule (PT) and other segments by activating adenosine type 1 receptors (A1-AR). We tested the hypothesis that A1-AR in the PT is regulated by salt intake and participates in the kidney adaptation to
Publikováno v:
Journal of Neurophysiology. 99:2985-2997
Dopaminergic modulation of prefrontal cortical activity is known to affect cognitive functions like working memory. Little consensus on the role of dopamine modulation has been achieved, however, in part because quantities directly relating to the ne
Autor:
Naeem Haider, John K. Jenkins, Abdulla K. Salahudeen, He Zhe, Manish Joshi, Ming Yang, Hong Huang, Harnish Patel
Publikováno v:
American Journal of Physiology-Renal Physiology. 294:F1354-F1365
Erythropoietin (Epo) induces erythrocytosis by suppressing erythroid progenitor cell apoptosis through the Janus-activated kinase-signal transducers and activators of transcription (JAK-STAT) pathway. Since apoptosis contributes to cisplatin (CP)-ind
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 294:L739-L748
Hyperoxic rats treated with inosine during oxygen exposure have increased levels of active transforming growth factor (TGF)-beta in the bronchoalveolar lavage (BAL), yet alveolar epithelial type 2 cells (AEC2) isolated from these animals demonstrate
Autor:
Muriel H. Larauche, Yvette Taché, James A. McRoberts, Peter G. McLean, Emeran A. Mayer, Mulugeta Million, Sylvie Bradesi
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 294:G1033-G1040
Visceral hypersensitivity has been implicated as an important pathophysiological mechanism in functional gastrointestinal disorders. In this study, we investigated whether the sustained visceral hyperalgesia induced by repeated psychological stress i
Autor:
James C. Leiter, Walter M. St. John
Publikováno v:
Journal of Applied Physiology. 104:665-673
In severe hypoxia or ischemia, normal eupneic breathing fails and is replaced by gasping. Gasping serves as part of a process of autoresuscitation by which eupnea is reestablished. Medullary neurons, having a burster, pacemaker discharge, underlie ga
Publikováno v:
Journal of Neurophysiology. 99:49-59
We studied sensitization of retrogradely labeled bladder sensory neurons and plasticity of P2X receptor function in a model of cystitis using patch-clamp techniques. Saline (control) or cyclophosphamide (CYP) was given intraperitoneally to rats on da
Autor:
Jason U. Tilan, Joseph Winaver, Zofia Zukowska, Susan E. Mulroney, Aviad Haramati, Ean Y. Callanan, Edward Lee
Publikováno v:
American Journal of Physiology-Renal Physiology. 293:F1811-F1817
Neuropeptide Y (NPY) is coreleased with norepinephrine and stimulates vasoconstriction, vascular and cardiomyocyte hypertrophy via Y1 receptors (R) and angiogenesis via Y2R. Although circulating NPY is elevated in heart failure, NPY's role remains un