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pro vyhledávání: '"11"'
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 268:L839-L845
Gene therapy of the fetus or newborn infant is a potentially useful approach for prevention or treatment of specific lung diseases. To begin to address issues such as efficiency, duration, and cellular distribution of transgene expression, we studied
Fetal origins of neonatal lung disease: understanding the pathogenesis of bronchopulmonary dysplasia
Autor:
Robin H. Steinhorn, Karen K. Mestan
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 301:L858-L859
in the early 1990s, Barker and colleagues (4) proposed that early events occurring before birth could produce later onset cardiovascular disease in the adult. This “fetal origins hypothesis” sparked the beginning of a new way of thinking among cl
Autor:
Carl W. White, Tiina M. Asikainen
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 293:L555-L556
THE FETUS DEVELOPS IN HYPOXIA (3–5% O2), which is essential for the vasculature. Vascular growth, in turn, is required for lung development (11). For these processes, the essential role of the transcription factor hypoxia-inducible factor (HIF) is
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 303:R778-R789
Male preterm infants are at greater risk of respiratory morbidity and mortality than females but mechanisms are poorly understood. Our objective was to identify the basis for the “male disadvantage” following preterm birth using an ovine model of
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 295:H1505-H1513
In addition to high pulmonary vascular resistance (PVR) and low pulmonary blood flow, the fetal pulmonary circulation is characterized by mechanisms that oppose vasodilation. Past work suggests that high myogenic tone contributes to high PVR and may
Autor:
Dennis W. Nielson, Dale L. Chapman, David P. Carlton, Richard D. Bland, Francis R Poulain, J. J. Cummings
Publikováno v:
Journal of Applied Physiology. 76:523-530
The goals of this study were 1) to examine changes in lung liquid formation and composition during spontaneous labor in fetal lambs and 2) to determine the importance of beta-adrenergic stimulation and transepithelial Na+ flux in removing liquid from
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 260:L280-L285
To examine mechanisms underlying fetal pulmonary vascular vasodilator responses and maturational changes in endothelial function, we studied effects of endothelium-dependent (acetylcholine, ACh: adenosine diphosphate, ADP; and A23187) and -independen
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 242:E378-E383
We studied the effects of thyroid hormones and malnutrition on protein, DNA, and phospholipid content of the developing rat lung during the first month of life. Neonatal hypothyroidism significantly decreases the lung phospholipid content by 30-45% b