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Publikováno v:
American Journal of Physiology-Renal Physiology. 320:F963-F971
Psychotropic drugs may be associated with hyponatremia, but an understanding of how they induce water retention in the kidney remains elusive. Previous studies have postulated that they may increase vasopressin production in the hypothalamus without
Autor:
Brigitte Leininger-Muller, Sarah El Hajj Chehadeh, Jean-Marc Alberto, Natacha Dreumont, Elise Jeannesson, Jean-Louis Guéant, Laetitia Canabady-Rochelle, Jean-Luc Daval, Jérèmy Willekens
Publikováno v:
AJP-Endocrinology and Metabolism
AJP-Endocrinology and Metabolism, American Physiological Society, 2014, 307 (11), pp.E1009-E1019. ⟨10.1152/ajpendo.00364.2014⟩
AJP-Endocrinology and Metabolism, American Physiological Society, 2014, 307 (11), pp.E1009-E1019. ⟨10.1152/ajpendo.00364.2014⟩
International audience; Early deficiency of the methyl donors folate and vitamin B12 produces hyperhomocysteinemia and cognitive and motor disorders in 21-day-old rat pups from dams fed a diet deficient in methyl donors during gestation and lactation
Publikováno v:
American Journal of Physiology-Renal Physiology. 303:F1307-F1314
The thick ascending limb of the loop of Henle (THAL) reabsorbs ∼30% of the filtered NaCl in a process mediated by the apical Na-K-2Cl cotransporter NKCC2. Stimulation of β-adrenergic receptors in the THAL enhances NaCl reabsorption and increases i
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 302:E747-E758
Glucocorticoids (GCs) have been demonstrated to act through both genomic and nongenomic mechanisms. The present study demonstrated that corticosterone rapidly suppressed the activity of N-methyl-d-aspartate (NMDA) receptors in cultured hippocampal ne
Autor:
Paolo Onori, Romina Mancinelli, Domenico Alvaro, Gianfranco Alpini, Anastasia Renzi, Yoshiyuki Ueno, Fanyin Meng, Mellanie White, Shannon Glaser, Heather Francis, Guido Carpino, Yuyan Han, Sharon DeMorrow, Julie Venter, Antonio Franchitto, Eugenio Gaudio
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 301:G634-G643
In bile duct-ligated (BDL) rats, large cholangiocytes proliferate by activation of cAMP-dependent signaling. Melatonin, which is secreted from pineal gland as well as extrapineal tissues, regulates cell mitosis by interacting with melatonin receptors
Autor:
Adriana C. C. Girardi, Renato O. Crajoinas, Thaissa Dantas Pessoa, Bruna Piccolo Muniz Pacheco, G Malnic, Lucilia Maria Abreu Lessa, Felipe Theocarides Oricchio
Publikováno v:
American Journal of Physiology-Renal Physiology. 301:F355-F363
Glucagon-like peptide-1 (GLP-1) is a gut incretin hormone considered a promising therapeutic agent for type 2 diabetes because it stimulates beta cell proliferation and insulin secretion in a glucose-dependent manner. Cumulative evidence supports a r
Autor:
Wen Yin, Rong Fan, Qin Cui, Dinghua Yi, Na Feng, Xi-Qing Sun, Liang Cheng, Zhao Yin, Shiqiang Yu, Jianming Pei, Shumiao Zhang, Hui Bi, Jin Ma, Yue-Min Wang, Jincheng Liu, Quan Yu Zhang, Hai-Tao Guo, Xin Sun
Publikováno v:
Journal of Applied Physiology. 105:569-574
The modulation of β-adrenoceptor signaling in the hearts of hindlimb unweighting (HU) simulated weightlessness rats has not been reported. In the present study, we adopted the rat tail suspension for 4 wk to simulate weightlessness; then the effects
Publikováno v:
Journal of Neurophysiology. 93:1406-1417
Receptor-mediated dopamine (DA) modulation of neuronal excitability in the nucleus accumbens (NAc) has been shown to be critically involved in drug addiction and a variety of brain diseases. However, the mechanisms underlying the physiological or pat
Autor:
Yinghong Chen, Bruce R. Ito, Lala Makhsudova, Sara Epperson, Francisco Villarreal, Jorge Suarez, Wolfgang H. Dillmann
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 287:H2478-H2486
Cardiac fibroblasts (CF) express adenosine (ADO) receptors, and pharmacological evidence suggests the possible involvement of the A2(A2aand A2b) receptor (A2aR and A2bR) subtypes in inhibiting cell functions involved in fibrosis. The main objective o
Publikováno v:
American Journal of Physiology-Renal Physiology. 286:F1120-F1126
The sensitivity of the Cl−/HCO3−exchanger to dopamine D1- and D2-like receptor stimulation in immortalized renal proximal tubular epithelial cells from the spontaneous hypertensive rat (SHR) and Wistar-Kyoto rat (WKY) was examined. The activity o