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Autor:
Danforth A. Newton, Rita M. Ryan, Manjeet K. Paintlia, Demetri D. Spyropoulos, Alan H. Jobe, Matthew W. Kemp, John E. Baatz
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Atrial natriuretic peptide (ANP) and its receptors natriuretic peptide receptor (NPR)-A and NPR-C are all highly expressed in alveolar epithelial type II cells (AEC2s) in the late-gestation ovine fetal lung and are dramatically decreased postnatally.
Autor:
Townsend Benard, Fei Peng, Donato A. Rivas, Adelino Sanchez Ramos da Silva, Roger A. Fielding, Lee M. Margolis
Publikováno v:
American Journal of Physiology-Cell Physiology
Understanding paradoxical responses to anabolic stimulation and identifying the mechanisms for this inconsistency in mobility-limited older adults may provide new targets for the treatment of sarcopenia. Our laboratory has discovered that dysregulati
Autor:
Yu-An Zhang, Johanne Pastor, Joshuah M Gagan, Orson W. Moe, Jianning Zhang, Connie C.W. Hsia, Khoa Cao, Taylor L. Davidson
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Normal lungs do not express α-Klotho (Klotho) protein but derive cytoprotection from circulating soluble Klotho. It is unclear whether chronic supranormal Klotho levels confer additional benefit. To address this, we tested the age-related effects of
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
We have previously reported that several patients with idiopathic pulmonary hypertension (PH) had different types of G6PD deficiency. However, the role of G6PD in PH is multifactorial because G6PD is involved in controlling oxidative stress, metaboli
Publikováno v:
Am J Physiol Cell Physiol
Chronic kidney disease (CKD) is associated with a substantial increased risk of cardiovascular disease. There is growing evidence that uremic metabolites, which accumulate in the blood with CKD, have detrimental impacts on endothelial cell health and
Autor:
Michael D. Dennis, Siddharth Sunilkumar, Shaunaci A. Stevens, Allyson L. Toro, Scot R. Kimball, Carson J. Purnell, Jaclyn E. Welles
Publikováno v:
Am J Physiol Endocrinol Metab
Increased expression of the peptide hormone retinol-binding protein 4 (RBP4) has been implicated in the development of insulin resistance, type 2 diabetes, and visual dysfunction. Prior investigations of the mechanisms that influence RBP4 synthesis h
Publikováno v:
Am J Physiol Cell Physiol
Cystic fibrosis (CF) lung disease persists and remains life-limiting for many patients. Elevated high-mobility group box-1 protein (HMGB-1) levels and epithelial sodium channel hyperactivity (ENaC) are hallmark features of the CF lung. The objective
Publikováno v:
American Journal of Physiology-Cell Physiology. 317:C1172-C1182
Selenoprotein W (SelW) is a selenium-containing protein with a redox motif found abundantly in the skeletal muscle of rodents. Previous in vitro studies suggest that SelW plays an antioxidant role; however, relatively few in vivo studies have address
Autor:
Hai-Rong Xiao, Haifa Xia, Lu Qin, Wei Xiong, Lin Chen, Jiqian Xu, You Shang, Yaxin Wang, Min Liu, Shengnan Li, Lisha Hu, Yiyi Yang, Shangwen Pan, Shu-Nan Cui, Limin Song, Ting Zhou, Shanglong Yao
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 316:L1013-L1024
Mechanical ventilation-induced pulmonary fibrosis plays an important role in the high mortality rate of acute respiratory distress syndrome (ARDS). Resolvin D1 (RvD1) displays potent proresolving activities. Epithelial-mesenchymal transition (EMT) ha
The E3 ligase MARCH5 is a PPARγ target gene that regulates mitochondria and metabolism in adipocytes
Autor:
Aldons J. Lusis, Simon T. Bond, Darren C. Henstridge, Bronwyn A. Kingwell, Sarah C. Moody, Yingying Liu, Andrea L. Hevener, Brian G. Drew, Anna C. Calkin, Paul Gregorevic, Mete Civelek, Claudio J. Villanueva
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 316:E293-E304
Mitochondrial dynamics refers to the constant remodeling of mitochondrial populations by multiple cellular pathways that help maintain mitochondrial health and function. Disruptions in mitochondrial dynamics often lead to mitochondrial dysfunction, w