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Autor:
Val J. Watts, Tarsis F. Brust, Roland Seifert, Justin E. LaVigne, Katrina F. Ostrom, Carmen W. Dessauer, Rennolds S. Ostrom
Publikováno v:
Physiol Rev
Adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1–9, that serve as major effector enzymes of G protein-coupled receptors (GPCRs). The trans
Autor:
Hans Ackerman, Mitchell J. Weiss, Miriam M. Cortese-Krott, Steven E. Brooks, Linda Columbus, T C Steven Keller, Christophe Lechauve, Brant E. Isakson, Alexander S. Keller
Publikováno v:
Physiol Rev
Globin proteins exist in every cell type of the vasculature, from erythrocytes to endothelial cells, vascular smooth muscle cells, and peripheral nerve cells. Many globin subtypes are also expressed in muscle tissues (including cardiac and skeletal m
Autor:
Maria E. Teves, Eduardo R. S. Roldan
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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The spermatozoon is a highly differentiated and polarized cell, with two main structures: the head, containing a haploid nucleus and the acrosomal exocytotic granule, and the flagellum, which generates energy and propels the cell; both structures are
Publikováno v:
Physiol Rev
Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and proliferation. The uptake of nutrients from the environment and their intracellular metabolism is a highly controlled process that involves cross talk between growt
Publikováno v:
Physiological Reviews. 101:683-731
Several diseases and conditions have been associated with an uncontrolled rise in bile acid (BA) concentrations. This is often the case when the tight feedback regulation of BA synthesis is compromised to the point that BAs become detrimental. BAs an
Autor:
Edward T.H. Yeh, Hui-Ming Chang
Publikováno v:
Physiol Rev
Sentrin/small ubiquitin-like modifier (SUMO) is protein modification pathway that regulates multiple biological processes, including cell division, DNA replication/repair, signal transduction, and cellular metabolism. In this review, we will focus on
Publikováno v:
Physiological Reviews. 99:1655-1699
Integrins are heterodimeric cell surface receptors ensuring the mechanical connection between cells and the extracellular matrix. In addition to the anchorage of cells to the extracellular matrix, these receptors have critical functions in intracellu
Autor:
Ole H. Petersen, Julia Vladimirovna Gerasimenko, Oleksiy Gryshchenko, Shuang Peng, Oleg Vsevolodovich Gerasimenko
This review deals with the roles of calcium and ATP in the control of the normal functions of the different cell types in the exocrine pancreas as well as the roles of these molecules in the pathophysiology of Acute Pancreatitis. Repetitive rises in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b021470b15a7f3fb99e38576c40a46af
https://orca.cardiff.ac.uk/id/eprint/141137/7/physrev.00003.2021.pdf
https://orca.cardiff.ac.uk/id/eprint/141137/7/physrev.00003.2021.pdf
Autor:
Brian Glancy, Robert S. Balaban
Publikováno v:
Physiol Rev
The design of the energy metabolism system in striated muscle remains a major area of investigation. Here, we review our current understanding and emerging hypotheses regarding the metabolic support of muscle contraction. Maintenance of ATP free ener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f663869093ee3cfd711d4514a3ea26ef
https://europepmc.org/articles/PMC8576364/
https://europepmc.org/articles/PMC8576364/
Publikováno v:
Physiological Reviews. 99:1249-1279
Nuclear receptors are intracellular proteins that act as transcription factors. Proteins with classic nuclear receptor domain structure lacking identified signaling ligands are designated orphan nuclear receptors. Two of these, steroidogenic factor-1