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Autor:
Ross A. D. Bathgate, Michelle L. Halls, Gabrielle E. Callander, Martina Kocan, E. T. van der Westhuizen, Roger J. Summers
Publikováno v:
Physiological Reviews. 93:405-480
There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has many roles in female and male reproduction, as a neuropeptide in the central nervous system, as a vasodilator and cardiac stimulant in the cardiovascula
Autor:
Kenneth B. Gagnon, Eric Delpire
Publikováno v:
Physiological Reviews. 92:1577-1617
SPAK (Ste20-related proline alanine rich kinase) and OSR1 (oxidative stress responsive kinase) are members of the germinal center kinase VI subfamily of the mammalian Ste20 (Sterile20)-related protein kinase family. Although there are 30 enzymes in t
Autor:
Lars Rönnstrand, Johan Lennartsson
Publikováno v:
Physiological Reviews. 92:1619-1649
Stem cell factor (SCF) is a dimeric molecule that exerts its biological functions by binding to and activating the receptor tyrosine kinase c-Kit. Activation of c-Kit leads to its autophosphorylation and initiation of signal transduction. Signaling p
Autor:
Michael J. Sanderson, Luc Leybaert
Publikováno v:
Physiological Reviews. 92:1359-1392
Intercellular calcium (Ca2+) waves (ICWs) represent the propagation of increases in intracellular Ca2+through a syncytium of cells and appear to be a fundamental mechanism for coordinating multicellular responses. ICWs occur in a wide diversity of ce
Autor:
Masatoshi Takeichi, Shinji Hirano
Publikováno v:
Physiological Reviews. 92:597-634
Cadherins are Ca2+-dependent cell-cell adhesion molecules that play critical roles in animal morphogenesis. Various cadherin-related molecules have also been identified, which show diverse functions, not only for the regulation of cell adhesion but a
Autor:
Rui Wang
Publikováno v:
Physiological Reviews. 92:791-896
The important life-supporting role of hydrogen sulfide (H2S) has evolved from bacteria to plants, invertebrates, vertebrates, and finally to mammals. Over the centuries, however, H2S had only been known for its toxicity and environmental hazard. Phys
Publikováno v:
Physiological Reviews
Protein folding is a complex, error-prone process that often results in an irreparable protein by-product. These by-products can be recognized by cellular quality control machineries and targeted for proteasome-dependent degradation. The folding of p
Autor:
Joseph Avruch, John M. Kyriakis
Publikováno v:
Physiological Reviews. 92:689-737
The mammalian stress-activated families of mitogen-activated protein kinases (MAPKs) were first elucidated in 1994, and by 2001, substantial progress had been made in identifying the architecture of the pathways upstream of these kinases as well as i
Publikováno v:
Physiological Reviews. 92:75-99
Since the realization that embryonic stem cells are maintained in a pluripotent state through the interplay of a number of key signal transduction pathways, it is becoming increasingly clear that stemness and pluripotency are defined by the complex m
Autor:
Murali Prakriya, Richard S. Lewis
Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in virtually all metozoan cells and serve a wide variety of functions ranging from gene expression, motility, and secretion to tissue and organ development and the immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc9f24fa0b8721874fa823dd3ff27f6
https://europepmc.org/articles/PMC4600950/
https://europepmc.org/articles/PMC4600950/