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Autor:
Val J. Watts, Tarsis F. Brust, Roland Seifert, Justin E. LaVigne, Katrina F. Ostrom, Carmen W. Dessauer, Rennolds S. Ostrom
Publikováno v:
Physiol Rev
Adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1–9, that serve as major effector enzymes of G protein-coupled receptors (GPCRs). The trans
Autor:
Hans Ackerman, Mitchell J. Weiss, Miriam M. Cortese-Krott, Steven E. Brooks, Linda Columbus, T C Steven Keller, Christophe Lechauve, Brant E. Isakson, Alexander S. Keller
Publikováno v:
Physiol Rev
Globin proteins exist in every cell type of the vasculature, from erythrocytes to endothelial cells, vascular smooth muscle cells, and peripheral nerve cells. Many globin subtypes are also expressed in muscle tissues (including cardiac and skeletal m
Publikováno v:
Physiol Rev
Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and proliferation. The uptake of nutrients from the environment and their intracellular metabolism is a highly controlled process that involves cross talk between growt
Autor:
Edward T.H. Yeh, Hui-Ming Chang
Publikováno v:
Physiol Rev
Sentrin/small ubiquitin-like modifier (SUMO) is protein modification pathway that regulates multiple biological processes, including cell division, DNA replication/repair, signal transduction, and cellular metabolism. In this review, we will focus on
Autor:
Brian Glancy, Robert S. Balaban
Publikováno v:
Physiol Rev
The design of the energy metabolism system in striated muscle remains a major area of investigation. Here, we review our current understanding and emerging hypotheses regarding the metabolic support of muscle contraction. Maintenance of ATP free ener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f663869093ee3cfd711d4514a3ea26ef
https://europepmc.org/articles/PMC8576364/
https://europepmc.org/articles/PMC8576364/
Autor:
Jeffrey L. Garvin, Fara Saez, Jessica Asirwatham, Agustin Gonzalez-Vicente, Casandra Margarita Monzón
Publikováno v:
Physiological Reviews. 99:235-309
The thick ascending limb plays a key role in maintaining water and electrolyte balance. The importance of this segment in regulating blood pressure is evidenced by the effect of loop diuretics or local genetic defects on this parameter. Hormones and
Autor:
Gerald W. Dorn, Åsa B. Gustafsson
Publikováno v:
Physiological Reviews. 99:853-892
The central functions fulfilled by mitochondria as both energy generators essential for tissue homeostasis and gateways to programmed apoptotic and necrotic cell death mandate tight control over the quality and quantity of these ubiquitous endosymbio
Publikováno v:
Physiological Reviews. 98:2025-2061
The vasculature is a remarkably interesting, complex, and interconnected organ. It provides a conduit for oxygen and nutrients, filtration of waste products, and rapid communication between organs. Much remains to be learned about the specialized vas
Autor:
William G. Robichaux, Xiaodong Cheng
Publikováno v:
Physiological Reviews
This review focuses on one family of the known cAMP receptors, the exchange proteins directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide exchange factors (cAMP-GEFs). Although EPAC proteins are fairly new additions
Publikováno v:
Physiological Reviews. 97:939-993
Dental enamel is the hardest and most mineralized tissue in extinct and extant vertebrate species and provides maximum durability that allows teeth to function as weapons and/or tools as well as for food processing. Enamel development and mineralizat