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Autor:
Danforth A. Newton, Rita M. Ryan, Manjeet K. Paintlia, Demetri D. Spyropoulos, Alan H. Jobe, Matthew W. Kemp, John E. Baatz
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Atrial natriuretic peptide (ANP) and its receptors natriuretic peptide receptor (NPR)-A and NPR-C are all highly expressed in alveolar epithelial type II cells (AEC2s) in the late-gestation ovine fetal lung and are dramatically decreased postnatally.
Publikováno v:
American Journal of Physiology-Cell Physiology. 322:C94-C110
Following anabolic stimuli (mechanical loading and/or amino acid provision), the mechanistic target of rapamycin complex 1 (mTORC1), a master regulator of protein synthesis, translocates toward the cell periphery. However, it is unknown if mTORC1-med
Autor:
Leslie E. Neidert, Matthew J. Rogatzki, L. Bruce Gladden, Brian S. Ferguson, Heidi A. Kluess, Keith R. Lohse
Publikováno v:
American Journal of Physiology-Cell Physiology. 321:C761-C769
The precise matching of blood flow to skeletal muscle during exercise remains an important area of investigation. Release of adenosine triphosphate (ATP) from red blood cells (RBCs) is postulated as a mediator of peripheral vascular tone in response
Publikováno v:
Am J Physiol Cell Physiol
Chronic kidney disease (CKD) is associated with a substantial increased risk of cardiovascular disease. There is growing evidence that uremic metabolites, which accumulate in the blood with CKD, have detrimental impacts on endothelial cell health and
Autor:
Michael D. Dennis, Siddharth Sunilkumar, Shaunaci A. Stevens, Allyson L. Toro, Scot R. Kimball, Carson J. Purnell, Jaclyn E. Welles
Publikováno v:
Am J Physiol Endocrinol Metab
Increased expression of the peptide hormone retinol-binding protein 4 (RBP4) has been implicated in the development of insulin resistance, type 2 diabetes, and visual dysfunction. Prior investigations of the mechanisms that influence RBP4 synthesis h
Autor:
Pamela J. Hornby, J. Matthew Hinkley, Donghai Zheng, Walter J. Pories, Benjamin A. Kugler, James Lenhard, G. Lynis Dohm, Kai Zou, Terry E. Jones, Kristen Turner, Joseph A. Houmard
Publikováno v:
Am J Physiol Cell Physiol
The purpose of this study was to determine whether intramyocellular glucose partitioning was altered in primary human myotubes derived from severely obese women with type 2 diabetes. Human skeletal muscle cells were obtained from lean nondiabetic and
Autor:
Juan Duarte, Grégoire Manaud, Frédéric Perros, Bianca Barreira, Laura Moreno, Gema Mondejar-Parreño, Daniel Morales-Cano, María Callejo, Sergio Esquivel-Ruiz, Francisco Perez-Vizcaino, Angel Cogolludo, Miguel A Olivencia
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 319:L627-L640
Vitamin D (VitD) receptor regulates the expression of several genes involved in signaling pathways affected in pulmonary hypertension (PH). VitD deficiency is highly prevalent in PH, and low levels are associated with poor prognosis. We investigated
Publikováno v:
American Journal of Physiology-Cell Physiology. 319:C441-C454
Skeletal muscle atrophy is caused by a decrease in muscle size and strength and results from a range of physiological conditions, including denervation, immobilization, corticosteroid exposure and aging. Newly named dual-specificity phosphatase 29 (
Autor:
Mauricio Castro-Sepulveda, German Tapia, Claudio Villagrán, Sebastian Jannas-Vela, Nicolás Quezada, Hermann Zbinden-Foncea, Rodrigo Fernández-Verdejo, Daniela Ávalos-Allele
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 318:E848-E855
Disturbances in skeletal muscle lipid oxidation might induce ectopic fat deposition and lipotoxicity. Nevertheless, the cellular mechanisms that regulate skeletal muscle lipid oxidation have not been fully determined. We aimed to determine whether th
Autor:
Bruno Gualano, Marcelo Miranda de Oliveira Lima, Lucas Peixoto Sales, Caroline de Andrade Kratz, Lívia de Souza Gonçalves, Tiemi Saito, Victor Henrique Carvalho, Guilherme Giannini Artioli, Bruno Geloneze, Lívia Santos, Joice Rodrigues, Marisa Helena Gennari de Medeiros, Kleiner Nemezio, Luiz Augusto Riani, Alan Lins Fernandes, Ruth M. James, Igor Longobardi, Craig Sale
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
To test whether high circulating insulin concentrations influence the transport of β-alanine into skeletal muscle at either saturating or subsaturating β-alanine concentrations, we conducted two experiments whereby β-alanine and insulin concentrat