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Autor:
Wenchong Song, Chengjian Shi
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 321:G477-G488
Pancreatic cancer (PC) is among the most notorious malignancies worldwide. Long noncoding RNA (lncRNA) repulsive guidance molecule bone morphogenetic protein (BMP) coreceptor b antisense RNA 1 (RGMB-AS1) was an oncogene in glioma. However, the RGMB-A
Autor:
Elena A. Goncharova, Yao Li, Sanghamitra Sahoo, Mauricio Rojas, Daniel de Jesus, Patrick J. Pagano, John Sembrat, Adam C. Straub, Eugenia Cifuentes-Pagano
Publikováno v:
Am J Physiol Heart Circ Physiol
Pulmonary arterial hypertension (PAH) is a fatal cardiopulmonary disease characterized by increased vascular cell proliferation with apoptosis resistance and occlusive remodeling of the small pulmonary arteries. The Notch family of proteins subserves
Autor:
Olin D Liang, Eui Young So, Keith Q. Wu, Anthony M. Reginato, Patrycja M. Dubielecka, Changqi Sun
Publikováno v:
Am J Physiol Cell Physiol
Rheumatoid arthritis (RA) is a debilitating autoimmune disease of unknown cause, characterized by infiltration and accumulation of activated immune cells in the synovial joints where cartilage and bone destructions occur. Myeloid-derived suppressor c
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 320:G1002-G1013
Tumor DDR1 acts as a key factor during the desmoplastic response surrounding hepatic colorectal metastasis. Hepatic sinusoidal cell-derived soluble factors stimulate tumor DDR1 activation. DDR1 modulates matrix remodeling to promote metastasis in the
Autor:
Na Li, Li-Gang Shi, Sheng-Li Zhou, Zhi-Feng Wang, Qian-Qian Lei, Yang Sun, Ling-Fei Kong, Yan Ping Guo, Xin-hua Wang, Qiong Cheng
Publikováno v:
American Journal of Physiology-Cell Physiology. 320:C880-C891
Renal cell carcinoma (RCC) has the highest mortality rate among urological cancers and tumor angiogenesis that plays a critical role in RCC progress. Epidermal growth factor-like domain multiple 7 (EGFL7) has been recently identified as a regulator i
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 320:G816-G828
Upregulating the expression of long noncoding RNA LINC00982 controlled cell proliferation in gastric cancer, but the regulatory molecular mechanisms are yet to be expounded. We here aimed to elaborate how LINC00982 regulated the malignancy of gastric
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 320:H1959-H1974
NGF PLGA nanoparticles can exert a protective effect on hUCMSCs and promote the paracrine effects of hUCMSCs on angiogenesis and cardiomyocyte protection through TrkA-PI3K/Akt signaling pathway, the same with free NGF. The application of NGF PLGA nan
Publikováno v:
Am J Physiol Renal Physiol
Retinoid acid (RA) is synthesized mainly in the liver and has multiple functions in development, cell differentiation and proliferation, and regulation of inflammation. RA has been used to treat multiple diseases, such as cancer and skin disorders. T
Autor:
Cara Clouse, Cole B. Peeler, Emily Whitaker, Gehad Mekky, Anna C. Deal, Michaela Gaffley, Anthony Atala, Marshall Z Schwartz, Victoria G. Weis, Jared A. Weis
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Necrotizing enterocolitis (NEC), a life-threatening intestinal disease, is becoming a larger proportionate cause of morbidity and mortality in premature infants. To date, therapeutic options remain elusive. Based on recent cell therapy studies, we in
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Butyrate is a short-chain fatty acid produced by colonic gut bacteria as a result of fermentation of dietary fibers. In the colon, butyrate is a major energy substrate and contributes to the nutritional support and proliferation of a healthy mucosa.