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Autor:
Kyungsoo Kim, Prince J. Kannankeril, Matthew B Murphy, Katherine T. Murray, Joey V. Barnett, Tuerdi Subati, Joseph C Van Amburg
Publikováno v:
Am J Physiol Heart Circ Physiol
Mice are routinely used to investigate molecular mechanisms underlying the atrial fibrillation (AF) substrate. We sought to optimize transesophageal rapid atrial pacing (RAP) protocols for the detection of AF susceptibility in mouse models. Hypertens
Autor:
Tina Vrabec, Una Buckley, Kalyanam Shivkumar, Niloy Bhadra, Christopher Chan, Corey Smith, Joseph Hadaya, Jeffrey L. Ardell, Nil Z. Gurel, Jonathan D. Hoang, Mohammed A. Swid
Publikováno v:
Am J Physiol Heart Circ Physiol
Maladaptation of the sympathetic nervous system contributes to the progression of cardiovascular disease and risk for sudden cardiac death, the leading cause of mortality worldwide. Axonal modulation therapy (AMT) directed at the paravertebral chain
Autor:
Daniel E. Rivera, Núria M. Pastor-Soler, Pei-Yin Ho, Valeria Mancino, Jessica Pham, Hui Li, Biagio Saitta, Kenneth R. Hallows
Publikováno v:
American Journal of Physiology-Renal Physiology. 322:F27-F41
Metformin treatment improved ADPKD disease severity in a relevant, slowly progressive ADPKD mouse model that recapitulates a PKD-associated PKD1 mutation. Relative to controls, metformin reduced kidney weight/body weight, cystic index and BUN levels,
Autor:
Mackenzie B Norman, Mary C. Esparza, John G. Lane, Shanelle N Dorn, Sydnee A Hyman, Shannon N. Bremner, Anshuman Singh, Laura S Vasquez-Bolanos, Donald C Fithian, Ivan Ramirez, Samuel R. Ward, Isabella T Wu
Publikováno v:
J Appl Physiol (1985)
Chronic rotator cuff tears can cause severe functional deficits. Addressing the chronic fatty and fibrotic muscle changes is of high clinical interest; however, the architectural and physiological consequences of chronic tear and repair are poorly ch
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 321:L991-L1005
Nocturnal asthma is characterized by heightened bronchial reactivity at night, and plasma melatonin concentrations are higher in patients with nocturnal asthma symptoms. Numerous physiological effects of melatonin are mediated via its specific G prot
Autor:
Erica Ferrini, Franco Fabio Stellari, Fabrizio Salomone, Luisa Ragionieri, Luisa Corsi, Francesca Pennati, Ludovica Leo, Chiara Catozzi
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 321:L1206-L1214
Micro-computed tomography (micro-CT) imaging is an emerging technology with many applications in small animals, for example, the study of pulmonary diseases, although clear guidelines and critical mass of evidence are still missing in the preclinical
Publikováno v:
Journal of Applied Physiology. 131:1460-1468
This study examined the effect of aerobic exercise with and without blood flow restriction (BFR) on exercise-induced hypoalgesia and endogenous opioid and endocannabinoid systems. In a randomized crossover design, pain-free individuals performed 20 m
Autor:
Saif I. Al-Juboori, Evgenia Dobrinskikh, David J. Orlicky, Clyde J. Wright, Durga Balasubramaniyan, Lijun Zheng, Laura G Sherlock, Robyn De Dios, Miguel A Zarate
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Both preclinical and clinical studies have demonstrated that exposures to acetaminophen (APAP) at levels that cause hepatic injury cause pulmonary injury as well. However, whether exposures that do not result in hepatic injury have acute pulmonary im
Autor:
Urs A. Leuenberger, Jonathan Luck, Jian Cui, Cheryl Blaha, Lawrence I. Sinoway, Takuto Hamaoka
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
The effects of nitroglycerin (glyceryl trinitrate, GTN) on baroreflex sensitivity (BRS) are incompletely understood. Moreover, there are no reports evaluating the acute responses in both the sympathetic BRS (SBRS) and the cardiovagal BRS (CBRS) to th
Autor:
Clarence E Locklear, Zachary T Glovak, Helen A. Baghdoyan, Christopher B O'Brien, Ralph Lydic, Diana Zebadua Unzaga
Publikováno v:
Journal of Neurophysiology. 126:1265-1275
The electroencephalogram (EEG) provides an objective, neural correlate of consciousness. Opioid receptors modulate mammalian neuronal excitability, and this fact was used to characterize how opioids administered to mice alter EEG power and states of