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Publikováno v:
Am J Physiol Regul Integr Comp Physiol
Psychomotor stimulants are prescribed for many medical conditions, including obesity, sleep disorders, and attention-deficit/hyperactivity disorder. However, despite their acknowledged therapeutic utility, these stimulants are frequently abused, and
Autor:
Katherine M. Mitchell, Karleigh E. Bradbury, Roy M. Salgado, Beau R. Yurkevicius, Nisha Charkoudian, Robert W. Kenefick, Charles S. Fulco, Kirsten E. Coffman
Publikováno v:
Journal of Applied Physiology. 128:390-396
Acetazolamide (AZ) is a medication commonly used to prevent acute mountain sickness (AMS) during rapid ascent to high altitude. However, it is unclear whether AZ use impairs exercise performance; previous literature regarding this topic is equivocal.
Autor:
Simon W. White, William T Harrison, Isabelle Doan, Nathan Hirshman, Huixia Jin, J. Todd Purves, Patrick D Leidig, Francis M. Hughes, Shelby N. Harper
Publikováno v:
Am J Physiol Renal Physiol
Recent breakthroughs demonstrate that peripheral diseases can trigger inflammation in the brain, causing psychosocial maladies, including depression. While few direct studies have been made, anecdotal reports associate urological disorders with menta
Autor:
Dimitri Laurent, Leonard M. Eisenberg, Sachindra R. Joshi, Elizabeth Sira, Maria A. Mitry, Carol A. Eisenberg, John G. Edwards, Sachin A. Gupte, Britny L. Keith
Publikováno v:
Am J Physiol Cell Physiol
Children surviving cancer and chemotherapy are at risk for adverse health events including heart failure that may be delayed by years. Although the early effects of doxorubicin-induced cardiotoxicity may be attributed to a direct effect on the cardio
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 318:R227-R233
Doxorubicin (DOX) is a highly effective antineoplastic agent used in cancer treatment. Unfortunately, clinical use of DOX is limited due to the development of dose-dependent toxicity to cardiac and respiratory (i.e., diaphragm) muscles. After adminis
Autor:
Theo Borghuis, Maarten van den Berge, Viacheslav O. Nikolaev, Wim Timens, Senani N H Rathnayake Mudiyanselage, Martina Schmidt, Alen Faiz, Janette K. Burgess, Haoxiao Zuo
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology, 318(1), L59-L64. AMER PHYSIOLOGICAL SOC
Cigarette smoke (CS), a highly complex mixture containing more than 4,000 compounds, causes aberrant cell responses leading to tissue damage around the airways and alveoli, which underlies various lung diseases. Phosphodiesterases (PDEs) are a family
Autor:
Gregory Guthrie, Charlotte Lauridsen, Douglas G. Burrin, Shaji Chacko, Barbara Stoll, Jogchum Plat
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology, 318(1), G41-G52. American Physiological Society
Guthrie, G, Stoll, B, Chacko, S, Lauridsen, C, Plat, J & Burrin, D G 2020, ' Rifampicin, not vitamin E, suppresses parenteral nutrition-associated liver disease development through the pregnane X receptor pathway in piglets ', American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 318, no. 1, pp. G41-G52 . https://doi.org/10.1152/ajpgi.00193.2019
Am J Physiol Gastrointest Liver Physiol
Guthrie, G, Stoll, B, Chacko, S, Lauridsen, C, Plat, J & Burrin, D G 2020, ' Rifampicin, not vitamin E, suppresses parenteral nutrition-associated liver disease development through the pregnane X receptor pathway in piglets ', American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 318, no. 1, pp. G41-G52 . https://doi.org/10.1152/ajpgi.00193.2019
Am J Physiol Gastrointest Liver Physiol
Infants receiving long-term parenteral nutrition (PN) develop PN-associated liver disease (PNALD). We previously (Ng K et al. JPEN J Parenter Enteral Nutr 40: 656–671, 2016. doi: 10.1177/0148607114567900 .) showed that PN containing soy-based lipid
Publikováno v:
Am J Physiol Renal Physiol
Cisplatin can cause acute kidney injury (AKI), but the molecular mechanisms are not well understood. The objective of the present study was to examine the role of transforming growth factor-β-activated kinase-1 (TAK1) in the pathogenesis of cisplati
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 318:E52-E61
Metformin is a widely prescribed antidiabetic agent, whereas Scutellaria baicalensis (SB) is a commonly used medicinal herb for treatment of type 2 diabetes (T2D). Gut microbiota is involved in pathophysiology of metabolic diseases including T2D, and
Autor:
Li Yuanyuan, Jia Zhanjun, Songming Huang, Xia Weiwei, Li Shuzhen, Yin Jie, Mengying Wu, Zhang Yue, Qian Wang, Aihua Zhang
Publikováno v:
American Journal of Physiology-Renal Physiology. 318:F96-F106
Cisplatin is one of the most effective antitumor agents, but its clinical use is highly limited by its severe side effects, especially nephrotoxicity. Recently, the active form of gasdermin D (GSDMD), termed GSDMD-N, was identified to mediate pyropto