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Autor:
Clarence E Locklear, Zachary T Glovak, Helen A. Baghdoyan, Christopher B O'Brien, Ralph Lydic, Diana Zebadua Unzaga
Publikováno v:
Journal of Neurophysiology. 126:1265-1275
The electroencephalogram (EEG) provides an objective, neural correlate of consciousness. Opioid receptors modulate mammalian neuronal excitability, and this fact was used to characterize how opioids administered to mice alter EEG power and states of
Publikováno v:
Physiology
The hypoxia-hypoxia-inducible factor (HIF)-1α-A2-adenosinergic pathway protects tissues from inflammatory damage during antipathogen immune responses. The elimination of this physiological tissue-protecting mechanism by supplemental oxygenation may
Autor:
Michael Christensen, Ida Rune, Mette V. Østergaard, Niels Vrang, Urmas Roostalu, Thomas Secher, Jacob Lercke Skytte, Lisbeth Nielsen Fink, Henrik H. Hansen, Casper Gravesen Salinas, Jacob Jelsing
Publikováno v:
American Journal of Physiology-Renal Physiology. 321:F149-F161
Translational animal models of diabetic kidney disease (DKD) are important tools in preclinical research and drug discovery. Here, we show that standard of care to control hypertension (lisinopril) and hyperglycemia (empagliflozin) improves kidney ph
Autor:
Daniel W. Shi, Yu Fu, Yanbo Tang, Xuan Zheng Shi, Shrilakshmi Hegde, Li Yen Mae Huang, You-Min Lin
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Constipation and abdominal pain are commonly encountered in opioid-induced bowel dysfunction (OBD). The underlying mechanisms are incompletely understood, and treatments are not satisfactory. As patients with OBD often have fecal retention, we aimed
Publikováno v:
American Journal of Physiology-Renal Physiology. 320:F1133-F1151
Although renin-angiotensin blockade has shown beneficial outcomes in patients with diabetes, renal injury progresses in most of these patients. Therefore, there remains a need for new therapeutic targets in diabetic kidney disease. Enhancement of vas
Autor:
Thomas M. Coffman, Donna L. Ralph, Rishav Adhikari, Alicia A. McDonough, Emre Dilmen, Alison N. Hollis, Susan B. Gurley, Thien A. Hoang, Fitra Rianto, Gabriel Chew, Enrico Petretto, Matthew A. Sparks, Edward J. Diaz
Publikováno v:
American Journal of Physiology : Renal Physiology, 320, F1080-F1092
American Journal of Physiology : Renal Physiology, 320, 6, pp. F1080-F1092
Am J Physiol Renal Physiol
American Journal of Physiology : Renal Physiology, 320, 6, pp. F1080-F1092
Am J Physiol Renal Physiol
Contains fulltext : 238842.pdf (Publisher’s version ) (Closed access) A major pathway in hypertension pathogenesis involves direct activation of ANG II type 1 (AT(1)) receptors in the kidney, stimulating Na(+) reabsorption. AT(1) receptors in tubul
Autor:
Evgenia Dobrinskikh, Brittany Butler, Clyde J. Wright, David J. Orlicky, Thom Sizemore, Lijun Zheng, Robyn De Dios, Laura G Sherlock, Durga Balasubramaniyan
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Acetaminophen ( n-acetyl-p-aminophenol, APAP) use in the neonatal intensive care unit is rapidly increasing. Although APAP-related hepatotoxicity is rarely reported in the neonatal literature, other end-organ toxicity can occur with toxic exposures.
Autor:
Manish Kumar, Kritika Khanna, Venkatesan Subramanian, Atish Gheware, Vaibhav Jain, Bhavana Prasher, Mitali Mukerji, S Kannan, Shakti Sagar, Anurag Agrawal, Vijay Pal Singh, Lipsa Panda, Naveen Kumar Bhatraju
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 320:L757-L769
Severe asthma is a chronic airway disease that exhibits poor response to conventional asthma therapies. Growing evidence suggests that elevated hypoxia increases the severity of asthmatic inflammation among patients and in model systems. In this stud
Publikováno v:
American Journal of Physiology-Renal Physiology. 320:F963-F971
Psychotropic drugs may be associated with hyponatremia, but an understanding of how they induce water retention in the kidney remains elusive. Previous studies have postulated that they may increase vasopressin production in the hypothalamus without
Autor:
Nicholas D. Fried, Jason D. Gardner, Tamara M. Morris, Eric Lazartigues, Xinping Yue, Anna Whitehead
Publikováno v:
Am J Physiol Heart Circ Physiol
Use of electronic cigarettes is rapidly increasing among youth and young adults, but little is known regarding the long-term cardiopulmonary health impacts of these nicotine-containing devices. Our group has previously demonstrated that chronic, inha