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Autor:
Daniel W. Shi, Yu Fu, Yanbo Tang, Xuan Zheng Shi, Shrilakshmi Hegde, Li Yen Mae Huang, You-Min Lin
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Constipation and abdominal pain are commonly encountered in opioid-induced bowel dysfunction (OBD). The underlying mechanisms are incompletely understood, and treatments are not satisfactory. As patients with OBD often have fecal retention, we aimed
Publikováno v:
American Journal of Physiology-Renal Physiology. 320:F963-F971
Psychotropic drugs may be associated with hyponatremia, but an understanding of how they induce water retention in the kidney remains elusive. Previous studies have postulated that they may increase vasopressin production in the hypothalamus without
Publikováno v:
Viisanen, H, Lilius, T O, Sagalajev, B, Rauhala, P, Kalso, E & Pertovaara, A 2020, ' Neurophysiological response properties of medullary pain-control neurons following chronic treatment with morphine or oxycodone : Modulation by acute ketamine ', Journal of Neurophysiology, vol. 124, no. 3, pp. 790-801 . https://doi.org/10.1152/jn.00343.2020
Descending facilitatory circuitry that involves the rostroventromedial medulla (RVM) exerts a significant role in the development of antinociceptive tolerance and hyperalgesia following chronic morphine treatment. The role of the RVM in the developme
Autor:
Brendan J. Canning, Taku Suzuki, Jin Magara, Izumi Ujihara, Takanori Tsujimura, Shogo Sakai, Makoto Inoue, Kojun Tsuji
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 312:G498-G507
Dysphagia is caused not only by neurological and/or structural damage but also by medication. We hypothesized memantine, dextromethorphan, diazepam, and baclofen, all commonly used drugs with central sites of action, may regulate swallowing function.
Publikováno v:
Journal of Neurophysiology. 117:836-845
Phrenic motor facilitation (pMF), a form of respiratory plasticity, can be elicited by acute intermittent hypoxia (i.e., phrenic long-term facilitation, pLTF) or direct application of drugs to the cervical spinal cord. Moderate acute intermittent hyp
Autor:
Brian T. Kadow, Timothy D. Lyon, James R. Roppolo, Changfeng Tai, Jicheng Wang, Zhaocun Zhang, William C. de Groat, Bing Shen, Vladimir Lamm
Publikováno v:
American Journal of Physiology-Renal Physiology. 311:F78-F84
This study investigated the role of the hypogastric nerve and β-adrenergic mechanisms in the inhibition of nociceptive and non-nociceptive reflex bladder activity induced by pudendal nerve stimulation (PNS). In α-chloralose-anesthetized cats, non-n
Autor:
Reid Hayward, Traci L. Parry
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 309:R675-R683
Highly effective anthracyclines, like doxorubicin (DOX), have limited clinical use due to protracted cardiotoxic effects. While exercise is known to be cardioprotective, it is unclear whether exercise compromises chemotherapy treatment efficacy. To d
Autor:
Corbin A. Shields, Denise C. Cornelius, Lateia Taylor, Alyssa Pennington, Bibek Poudel, Jan M. Williams, Kasi C McPherson, Denisha Spires, Brianca Fizer
The endothelin (ET) system has emerged as a therapeutic target for the treatment of diabetic nephropathy (DN). The present study examined whether chronic endothelin A (ETA) receptor blockade with atrasentan prevents the progression of renal injury in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea78bb7a3316aadcc6b23c474b6e7494
https://europepmc.org/articles/PMC6230747/
https://europepmc.org/articles/PMC6230747/
Autor:
Mahtab Moayeri, Stephen H. Leppla, Yan Li, Peter Q. Eichacker, Wanying Xu, Yvonne Fitz, Dante A. Suffredini, Xizhong Cui
Although edema toxin (ETx) and lethal toxin (LTx) contribute to Bacillus anthracis shock and lethality, the mechanisms underlying their cardiovascular effects are unclear. We have previously shown that ETx but not LTx inhibited phenylephrine-stimulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3017d71feb229b6c33cae9c6f2b9714
https://europepmc.org/articles/PMC5792197/
https://europepmc.org/articles/PMC5792197/
Autor:
Alison M. Gurney, Roman Mizera, Vojtech Sedivy, Youssef Ghaly, Marie Zaloudikova, Jana Novotná, Jan Herget, Shreena Joshi, Sean Brennan
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology
Hypoxic pulmonary vasoconstriction (HPV) is a beneficial mechanism that diverts blood from hypoxic alveoli to better ventilated areas of the lung, but breathing hypoxic air causes the pulmonary circulation to become hypertensive. Responses to airway