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Autor:
Clarence E Locklear, Zachary T Glovak, Helen A. Baghdoyan, Christopher B O'Brien, Ralph Lydic, Diana Zebadua Unzaga
Publikováno v:
Journal of Neurophysiology. 126:1265-1275
The electroencephalogram (EEG) provides an objective, neural correlate of consciousness. Opioid receptors modulate mammalian neuronal excitability, and this fact was used to characterize how opioids administered to mice alter EEG power and states of
Autor:
Nicholas D. Fried, Jason D. Gardner, Tamara M. Morris, Eric Lazartigues, Xinping Yue, Anna Whitehead
Publikováno v:
Am J Physiol Heart Circ Physiol
Use of electronic cigarettes is rapidly increasing among youth and young adults, but little is known regarding the long-term cardiopulmonary health impacts of these nicotine-containing devices. Our group has previously demonstrated that chronic, inha
Publikováno v:
Journal of Neurophysiology. 125:1202-1212
Cisplatin is an antitumor drug that is widely used for the treatment of various solid tumors. Unfortunately, patients are often troubled by serious side effects, especially hearing loss. Up to now, there have been no clear and effective measures to p
Autor:
Jasneet Parmar, James Howells, Daniel White, David Goldstein, Susanna B. Park, Justin G. Lees, Preet G.S. Makker, Gila Moalem-Taylor
Publikováno v:
Journal of Neurophysiology. 124:232-244
Oxaliplatin chemotherapy produces acute changes in peripheral nerve excitability in humans by modulating voltage-gated Na+ channel activity. However, there are few animal studies of oxaliplatin-induced neuropathy that demonstrate similar changes in e
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 318:R843-R854
Cisplatin is a well-known chemotherapy medication used to treat numerous cancers. However, treatment with cisplatin in cancer therapy has major side effects, such as nephrotoxic acute kidney injury. Adult vertebrate kidneys are commonly used as model
Autor:
Xinshou Ouyang, Yanqin Qin, Yonglin Chen, Yasuko Iwakiri, Natalie J. Török, Joy X. Jiang, Suyavaran Arumugam, Muhammad N. Yousaf, Sheng Na Han, Peng Zhao, Mohd Salah Mankash, Junbao Liu, Jiansheng Li
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
The cardiac glycoside digoxin was identified as a potent suppressor of pyruvate kinase isoform 2-hypoxia-inducible factor-α (PKM2-HIF-1α) pathway activation in liver injury mouse models via intraperitoneal injection. We have assessed the therapeuti
Publikováno v:
J Neurophysiol
We have investigated the potential acute desensitizing role of the β arrestin 2 (β-arr2) pathway on the ventilatory depression produced by levels of fentanyl ranging from analgesic to life-threatening (0.1 to 60 mg/kg ip) in control and β-arr2-def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c787e2b1445db2331f8a8325eea68c2
https://europepmc.org/articles/PMC8282230/
https://europepmc.org/articles/PMC8282230/
Autor:
Michael Z. Cicha, David K. Meyerholz, Madhu V. Singh, Mark W. Chapleau, Francois M. Abboud, Sarah Nunez
Publikováno v:
Am J Physiol Heart Circ Physiol
Toll-like receptors (TLR) are key components of the innate immune system that elicit inflammatory responses through the adaptor proteins myeloid differentiation protein 88 (MyD88) and Toll-interleukin receptor domain-containing adaptor protein-induci
Publikováno v:
American Journal of Physiology-Renal Physiology. 315:F469-F478
As a potent chemotherapy drug, cisplatin is also notorious for its side-effects including nephrotoxicity in kidneys, presenting a pressing need to identify renoprotective agents. Cisplatin nephrotoxicity involves epigenetic regulations, including cha
Autor:
Pablo A. Ortiz, Pamela Harding, Tengis S. Pavlov, Safa Z Khan, Edward L. Peterson, Jiang Xu, Timothy D Bryson, Teja S Pandrangi
Publikováno v:
Am J Physiol Heart Circ Physiol
Angiotensin II (ANG II) plays a key role in regulating blood pressure and inflammation. Prostaglandin E2 (PGE2) signals through four different G protein-coupled receptors, eliciting a variety of effects. We reported that activation of the EP3 recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f1d8da30d2dc4ca57edfc2f23a2d53
https://europepmc.org/articles/PMC7191497/
https://europepmc.org/articles/PMC7191497/