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Autor:
Takakazu Yagi, Hirotaka Ueda, Tomoyuki Kuwaki, Ikue Kusumoto-Yoshida, Hideki Kashiwadani, Shouichi Miyawaki, Mayu Suga
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 311:R964-R970
The aim of this study was to clarify the effect of vagal afferent activation on salivation and swallowing-like events. Salivation is part of a reflex induced by stimulation of the oral area during feeding or chewing. Recently, we reported that nausea
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 311:G501-G513
Opioids are one of the most prescribed drug classes for treating acute pain. However, chronic use is often associated with tolerance as well as debilitating side effects, including nausea and dependence, which are mediated by the central nervous syst
Publikováno v:
American Journal of Physiology-Renal Physiology. 313:F859-F861
The mechanisms leading to improvement of overactive bladder syndrome upon treatment with a β3-adrenoceptor agonist remain controversial. New research points to a role of inhibition of neuronal acetylcholine release. Whether this occurs by a direct e
Autor:
Mikael Adner, Olivia Larsson, Magnus Starkhammar, Susanna Kumlien Georén, Lars-Olaf Cardell, Barbara Fuchs, Martijn L. Manson
Publikováno v:
American Journal of Physiology, 310(11), L1121-L1129
Toll-like receptor (TLR) 7 agonists are known to reduce allergic airway inflammation. Their recently reported ability to rapidly relax airways has further increased their interest in the treatment of pulmonary disease. However, the mechanisms behind
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 310:H1321-H1329
Chronic cerebral hypoperfusion is a risk factor for cognitive impairment. Reduced blood flow through the common carotid arteries induced by bilateral carotid artery stenosis (BCAS) is a physiologically relevant model of chronic cerebral hypoperfusion
Autor:
Beth A. Taylor, Sophia Dyer, Pil-Ki Min, Aaron L. Baggish, Pierre A. d’Hemecourt, Stephanie K. Isaacs, Stephen Y. Chan, Chris Troyanos, Paul D. Thompson, Joseph Park
Publikováno v:
Journal of Applied Physiology. 120:711-720
Statins exacerbate exercise-induced skeletal muscle injury. Muscle-specific microRNAs (myomiRs) increase in plasma after prolonged exercise, but the patterns of myomiRs release after statin-associated muscle injury have not been examined. We examined
Publikováno v:
Journal of Applied Physiology. 119:1494-1500
Low doses of the carbonic anhydrase inhibitor acetazolamide provides accelerated acclimatization to high-altitude hypoxia and prevention of cerebral and other symptoms of acute mountain sickness. We previously observed increases in cerebral O2 metabo
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 309:H1314-H1325
Critically ill children can develop bleeding complications when treated with heparin-like drugs. These events are usually attributed to the anticoagulant activity of these drugs. However, previous studies showed that fibroblast growth factor-2 (FGF-2
Autor:
Yasunobu Iwata, Naoki Suenaga, Masataka Adachi, Kenichiro Kitamura, Yuki Narita, Yuichiro Izumi, Hirofumi Jono, Teruhiko Mizumoto, Hideyuki Saito, Masashi Mukoyama, Terumasa Nakagawa, Yoshikazu Miyasato, Takashige Kuwabara, Yutaka Kakizoe
Cisplatin (CDDP) is a widely-used chemotherapeutic drug for solid tumors, but its nephrotoxicity is a major dose-limiting factor. Doxycycline (Dox) is a tetracycline antibiotic that has been commonly used in a variety of infections. Dox has been show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef516a3ad181a3d24346c9aeef5f2f6e
https://europepmc.org/articles/PMC6293283/
https://europepmc.org/articles/PMC6293283/
Patients with peripheral artery disease show an exaggerated pressor response to mild exercise, an effect attributable to the exercise pressor reflex, whose afferent arm comprises the thinly myelinated group III and unmyelinated group IV afferents. Pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc68d02a1a580d19dcfa069e2f0a02d
https://europepmc.org/articles/PMC6032119/
https://europepmc.org/articles/PMC6032119/